[1]李文超.曼月乐联合GnRH-α对子宫腺肌症患者子宫血流动力学及炎症因子水平的影响[J].医学信息,2020,33(11):147-148.[doi:10.3969/j.issn.1006-1959.2020.11.047]
　LI Wen-chao.Effects of Manyule Combined with GnRH-α on Uterine Hemodynamics and Inflammatory Factors in Patients with Adenomyosis[J].Medical Information,2020,33(11):147-148.[doi:10.3969/j.issn.1006-1959.2020.11.047]
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曼月乐联合GnRH-α对子宫腺肌症患者子宫血流动力学及炎症因子水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年11期
页码:
147-148
栏目:
药物与临床
出版日期:
2020-06-01

文章信息/Info

Title:
Effects of Manyule Combined with GnRH-α on Uterine Hemodynamics and Inflammatory Factors in Patients with Adenomyosis
文章编号:
1006-1959（2020）11-0147-03
作者:
李文超
（佳木斯市中心医院妇产科，黑龙江 佳木斯 154002）
Author(s):
LI Wen-chao
(Department of Obstetrics and Gynecology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
子宫腺肌症; 曼月乐; GnRH-α; 基质金属蛋白酶9
Keywords:
Adenomyosis; Manyule; GnRH-α; Matrix metalloproteinase 9
分类号:
R711.71
DOI:
10.3969/j.issn.1006-1959.2020.11.047
文献标志码:
A
摘要:
目的 探讨曼月乐联合促性腺激素释放激素激动剂类药物（GnRH-α）对子宫腺肌症患者血流动力学及炎症因子水平的影响。方法 选择2018年4月~2019年5月佳木斯市中心医院妇产科收治的子宫腺肌症患者94例，按随机数表法分为对照组和观察组，各47例。对照组采用曼月乐联合屈螺酮炔雌醇治疗，观察组采用曼月乐联合GnRH-α治疗，比较两组治疗3个月后血流动力学[子宫动脉的最大血流速度（Vmax）、最小血流速度（Vmin）和阻力指数（RI）]、炎症因子水平[血清基质金属蛋白酶2（MMP-2）以及基质金属蛋白酶9（MMP-9）]。结果 治疗后，观察组子宫动脉Vmax[（20.73±1.98）cm/s]、Vmin[（9.21±0.84）cm/s]均低于对照组的（25.67±2.11）cm/s、（12.54±1.13）cm/s，RI为（0.81±0.13），高于对照组的（0.81±0.13）（P＜0.05）；治疗后观察组MMP-2为（59.64±4.32）ng/ml，MMP-9为（67.22±2.65）ng/ml，低于对照组的（66.35±6.28）ng/ml、（73.68±3.47）ng/ml（P＜0.05）。结论 子宫腺肌症患者采用曼月乐联合GnRH-α治疗有助于减小子宫体积及子宫内膜厚度，改善血流状况，降低炎症因子水平。
Abstract:
Objective To investigate the effect of Manyule combined with gonadotropin-releasing hormone agonist (GnRH-α) on hemodynamics and inflammatory factors in patients with adenomyosis.Methods From April 2018 to May 2019, 94 patients with adenomyosis were treated in the Obstetrics and Gynecology Department of Jiamusi Central Hospital, and they were divided into a control group and an observation group according to the random number table method, each with 47 cases. The control group was treated with Manyule and drospirenone ethinylestradiol, and the observation group was treated with Manyule and GnRH-α, comparing the hemodynamics of the two groups after 3 months of treatment [Maximum blood flow velocity of uterine artery (Vmax) ,minimum blood flow velocity (Vmin) and resistance index (RI)] and inflammatory factor levels [serum matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9)].Results After treatment, the uterine artery Vmax [(20.73±1.98) cm/s] and Vmin[(9.21±0.84)cm/s] of the observation group were lower than those of the control group (25.67±2.11) cm / s and (12.54±1.13)cm/s s, RI was (0.81±0.13), higher than the control group (0.81±0.13)(P＜0.05); MMP-2 in the observation group after treatment was (59.64±4.32) ng/ml, MMP -9 is (67.22±2.65) ng/ml, which is lower than that of the control group (66.35±6.28) ng/ml and (73.68±3.47) ng/ml(P＜0.05).Conclusion The treatment of adenomyosis patients with Manyule combined with GnRH-α is helpful to reduce the uterine volume and endometrial thickness, improve blood flow status, and reduce the level of inflammatory factors.

参考文献/References:

[1]李宝萍.醋酸亮丙瑞林联合腹腔镜切除病灶治疗子宫腺肌症的疗效及不良反应[J].实用医学杂志,2016,32(3):502-503.[2]赵颖.GnRH-a联合LNG-IUS治疗子宫腺肌症的效果观察[J].中国妇幼保健,2017,32(6):1194-1196.[3]沈维维,虞晓潇.局限性子宫腺肌症病灶切除术后联合GNRH-a、曼月乐治疗的效果观察[J].浙江临床医学,2018,20(3):471-473.[4]侯杰.曼月乐联合GnRH-α治疗子宫腺肌症的疗效评价研究[J].实用药物与临床,2018,21(3):269-271.[5]袁静,孟戈,方瑞娟,等.GnRH-a联合曼月乐治疗巨大子宫腺肌病的临床分析研究[J].北京医学,2017,39(8):78-81.

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更新日期/Last Update: 1900-01-01