[1]蒲军亮,张 婷.沙库巴曲缬沙坦钠片联合琥珀酸美托洛尔缓释片治疗慢性心力衰竭的疗效观察[J].医学信息,2020,33(14):159-160.[doi:10.3969/j.issn.1006-1959.2020.14.051]
　PU Jun-liang,ZHANG Ting.Observation of Sacubitril Valsartan Sodium Tablets Combined with Metoprolol Succinate Sustained-release Tablets in the Treatment of Chronic Heart Failure[J].Medical Information,2020,33(14):159-160.[doi:10.3969/j.issn.1006-1959.2020.14.051]
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沙库巴曲缬沙坦钠片联合琥珀酸美托洛尔缓释片治疗慢性心力衰竭的疗效观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年14期
页码:
159-160
栏目:
药物与临床
出版日期:
2020-07-15

文章信息/Info

Title:
Observation of Sacubitril Valsartan Sodium Tablets Combined with Metoprolol Succinate Sustained-release Tablets in the Treatment of Chronic Heart Failure
文章编号:
1006-1959（2020）14-0159-02
作者:
蒲军亮; 张 婷
（定西市人民医院心脏中心1，神经内科2，甘肃 定西 743000）
Author(s):
PU Jun-liang; ZHANG Ting
(Heart Center1,Department of Neurology2,Dingxi People’s Hospital,Dingxi 743000,Gansu,China)
关键词:
沙库巴曲缬沙坦钠; 琥珀酸美托洛尔; 倍他乐克; 慢性心力衰竭
Keywords:
Sacubatril valsartan sodium; Metoprolol succinate; Metoprolol; Chronic heart failure
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2020.14.051
文献标志码:
A
摘要:
目的 探讨沙库巴曲缬沙坦钠片联合琥珀酸美托洛尔缓释片治疗慢性心力衰竭的临床疗效。方法 选取2018年6月~2019年6月于定西市人民医院心脏中心住院的慢性心力衰竭患者67例，随机分为对照组和治疗组。对照组34例给予琥珀酸美托洛尔缓释片治疗，治疗组33例在对照组基础上加用沙库巴曲缬沙坦钠，比较两组治疗总有效率，治疗前后B型利钠肽水平（BNP）、左室射血分数（LVEF）、左室收缩末直径（LVDs）、左室舒张末直径（LVEDD）、不良反发生情况。结果 治疗后治疗组总有效率、LVEF均高于对照组，血清BNP水平、左室舒张末内径均低于对照组，差异有统计学意义（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 沙库巴曲缬沙坦钠联合琥珀酸美托洛尔治疗慢性心力衰竭疗效确切，有助于改善心衰指标，且不增加不良反应。
Abstract:
Objective To explore the clinical efficacy of sacubatril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets in the treatment of chronic heart failure.Methods From June 2018 to June 2019, 67 patients with chronic heart failure who were hospitalized in the heart center of Dingxi People’s Hospital were randomly divided into a control group and a treatment group. 34 cases in the control group were treated with metoprolol succinate sustained-release tablets, and 33 cases in the treatment group were added with sacurabatril valsartan sodium on the basis of the control group to compare the total treatment efficiency of the two groups.Levels of B-type natriuretic peptide, left ventricular ejection fraction, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, and adverse reactions before and after treatment.Results After treatment, the total effective rate and left ventricular ejection fraction of the treatment group were higher than those of the control group. The serum BNP level and the left ventricular end-diastolic diameter were lower than the control group, the difference was statistically significant (P＜0.05); The incidence of adverse reactions between the two groups was not statistically significant (P＞0.05).Conclusion The effect of sacubitril valsartan sodium combined with metoprolol succinate in the treatment of chronic heart failure is definite.

参考文献/References:

[1]高扬,栾波,高尧,等.沙库巴曲/缬沙坦治疗慢性心力衰竭的临床观察[J].中国循证心血管医学杂志,2019,11(5):595-597.[2]Basile JN,Bloch MJ.Combination angiotensin receptor blocker-neutral endopeptidase inhibitor provides additive blood pressure reduction over angiotensin receptor blocker alone[J].The Journal of Clinical Hypertension,2010,12(10):809-812.[3]周京敏,崔晓通,葛均波.中国心力衰竭的流行病学概况[J].中华心血管病杂志,2015,43(12):1018-1021.[4]黎伟强.胺碘酮联合琥珀酸美托洛尔对慢性心力衰竭合并快室率心房颤动临床观察[J].中国循证心血管医学杂志,2016,8(2):189-191.

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更新日期/Last Update: 1900-01-01