[1]陈启松,何海军,谷光敏,等.IL-6基因多态性与心房颤动相关性的Meta分析[J].医学信息,2020,33(23):73-76.[doi:10.3969/j.issn.1006-1959.2020.23.021]
　CHEN Qi-song,HE Hai-jun,GU Guang-min,et al.Meta Analysis of the Correlation Between IL-6 Gene Polymorphism and Atrial Fibrillation[J].Medical Information,2020,33(23):73-76.[doi:10.3969/j.issn.1006-1959.2020.23.021]
点击复制

IL-6基因多态性与心房颤动相关性的Meta分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年23期
页码:
73-76
栏目:
论著
出版日期:
2020-12-01

文章信息/Info

Title:
Meta Analysis of the Correlation Between IL-6 Gene Polymorphism and Atrial Fibrillation
文章编号:
1006-1959（2020）23-0073-04
作者:
陈启松; 何海军; 谷光敏; 等
（1.安徽省含山县人民医院心血管内科，安徽 含山 238100； 2.济宁医学院临床医学院，山东 济宁 272067）
Author(s):
CHEN Qi-song; HE Hai-jun; GU Guang-min; et al
(1.Department of Cardiology,the People’s Hospital of Hanshan County,Hanshan 238100,Anhui,China; 2.Clinical Medical College of Jining Medical University,Jining 272067,Shandong,China)
关键词:
IL-6; 基因多态性; 心房颤动
Keywords:
IL-6; Gene polymorphism; Atrial fibrillation
分类号:
R541.7+5
DOI:
10.3969/j.issn.1006-1959.2020.23.021
文献标志码:
A
摘要:
目的 分析IL-6基因多态性与心房颤动发病风险的相关性研究。方法 计算机检索万方、知网、维普、PubMed等数据库，检索关于IL-6基因多态性与心房颤动的病例对照研究，检索时间区间均从建库至2019年12月。对于纳入的研究，应用Rev Man5.3软件进行分析。结果 共纳入7项研究，Meta分析结果显示，IL-6-572C/G、IL-6-634C/G多态性与心房颤动明显相关（P＜0.01），其中IL-6-572C/G基因多态性中，携带GG基因型的个体患者心房颤动的风险是携带CC个体的3.39倍[95%CI（2.18，5.29），P＜0.00001]，携带GC基因型的个体患者心房颤动的风险是携带CC个体的1.58倍[95%CI（1.30，1.92），P＜0.00001]；IL-6-634C/G基因多态性中，携带GG基因型的个体患者心房颤动的风险是携带CC个体的5.80倍[95%CI（1.15，29.39），P=0.03]。而IL-6-174G/C、IL-6-597G/A多态性与心房颤动无关。结论 IL-6-572C/G基因型GG、GC和IL-6-634C/G基因型GG可能是心房颤动发生的风险基因型。
Abstract:
Objective To study the correlation between IL-6 gene polymorphism and atrial fibrillation risk.Methods The computer searched Wanfang, HowNet, Weipu, PubMed and other databases to search for case-control studies on IL-6 gene polymorphism and atrial fibrillation. The search time interval was from the establishment of the database to December 2019. For the included studies, Rev Man5.3 software was used for analysis.Results A total of 7 studies were included. The results of Meta analysis showed that IL-6-572C/G and IL-6-634C/G polymorphisms were significantly related to atrial fibrillation (P<0.01), among which IL-6-572C/G genes were the morphology, the risk of atrial fibrillation in individuals with GG genotype is 3.39 times that of individuals with CC [95%CI(2.18, 5.29),P＜0.00001]. The risk of atrial fibrillation in individuals with GC genotype is that of carrying 1.58 times that of individuals with CC [95%CI(1.30, 1.92),P＜0.00001]; among IL-6-634C/G gene polymorphisms, the risk of atrial fibrillation in individuals with GG genotype is 5.80 compared with individuals with CC Times [95%CI(1.15, 29.39),P=0.03]. The IL-6-174G/C and IL-6-597G/A polymorphisms have nothing to do with atrial fibrillation.Conclusion IL-6-572C/G genotype GG, GC and IL-6-634C/G genotype GG may be risk genotypes for atrial fibrillation.

参考文献/References:

[1]Lazzerini PE,Laghi-Pasini F,Acampa M,et al.Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling:The Role of Interleukin-6-Mediated Changes in Connexin Expression[J].Journal of the American Heart Association,2019,8(16):e011006. [2]Yang X,Yan H,Jiang N,et al.IL-6 Trans-signaling Drives a STAT3-dependent Pathway That Leads to Structural Alterations of Peritoneal Membrane[J].Am J Physiol Renal Physiol,2019,318(2):F338-F353. [3]Markousis-Mavrogenis G,Tromp J,Ouwerkerk W,et al.The clinical significance of interleukin-6 in heart failure:results from the BIOSTAT-CHF study[J].European Journal of Heart Failure,2019,21(8):965-973. [4]Rivera-Caravaca JM,Marín F,Vilchez JA,et al.Refining Stroke and Bleeding Prediction in Atrial Fibrillation by Adding Consecutive Biomarkers to Clinical Risk Scores[J].Stroke,2019,50(6):1372-1379. [5]Gaudino M,Andreotti F,Zamparelli R,et al.The -174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation is atrial fibrillation an inflammatory complication[J].Circulation,2003,108(Suppl 1):Ⅱ195-Ⅱ199. [6]Shen XB,Zhang SH,Li HY,et al.Rs12976445 Polymorphism Is Associated with Post-Ablation Recurrence of Atrial Fibrillation by Modulating the Expression of MicroRNA-125a and Interleukin-6R[J].Med Sci Monit,2018(24):6349-6358. [7]Carrero JJ,Andersson Franko M,Obergfell A,et al.hsCRP Level and the Risk of Death or Recurrent Cardiovascular Events in Patients With Myocardial Infarction:a Healthcare-Based Study[J].Am Heart Assoc,2019,8(11):e012638. [8]Chua W,Purmah Y,Cardoso VR,et al.Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation[J].Eur Heart,2019,40(16):1268-1276. [9]Geng HH,Li R,Su YM,et al.A functional single-nucleotide polymorphism in interleukin-6 promoter is associated with wave dispersion in hypertensive subjects with atrial fibrillation[J].Int J Clin Exp Med,2014,7(11):4434-4440. [10]Bin Waleed K,Yin X,Yang X,et al.Short and long-term changes in platelet and inflammatory biomarkers after cryoballoon and radiofrequency ablation[J].Int J Cardiol,2019(285):128-132. [11]Sierra LJ,Brown AG,Barilá GO,et al.Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice[J].PLoS One,2018,13(1):e0191524. [12]Murakami M,Kamimura D,Hirano T.Pleiotropy and Specificity:Insights from the Interleukin 6 Family of Cytokines[J].Immunity,2019,50(4):812-831. [13]Bialuk I,Winnicka MM.Facilitatory Effect of IL-6 Deficiency on Long-Term Spatial Memory in Young Adult Mice[J].Behav Genet,2018,48(3):236-246. [14]Mao L,Geng GY,Han WJ,et al.Interleukin-6(IL-6)-174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population[J].Genet Mol Res,2016,15(2). [15]刘佳顺,任澎.IL-6-174G/C基因多态性与心房颤动的关系[J].西部医学,2009,21(6):901-903. [16]李娜,王淑霞,木胡牙提.IL-6-174G/C及-572C/G位点基因多态性与新疆NVAF人群及民族差异性分析[J].重庆医学,2017,46(7):875-878. [17]郑金国,高淑萍,葛利军,等.心房颤动与白介素-6-174G/C、-572C/G、-597G/A位点基因多态性的关系[J].天津医药,2011,39(1):4-6. [18]付海霞,张嘉莹,赵子牛,等.白细胞介素6基因-597G/A与-572C/G多态性对心房颤动发病易感性的影响[J].中华心律失常学杂志,2013,17(3):200-204. [19]孟巳琦.新疆维、汉民族白介素-6-174G/C、-572C/G、-597G/A位点基因多态性与心房颤动易感性的关系[D].新疆医科大学,2015. [20]阿丽米拉·叶尔波拉提,木胡牙提,卢武红,等.炎症因子的基因多态性对房颤患者的影响研究[J].中华医院感染学杂志,2014,24(6):1311-1313. [21]Li J,Song J,Jiang MH,et al.Interleukin-6 promoter polymorphisms and susceptibility to atrial fibrillation in elderly Han Chinese patients with essential hypertension[J].J Interferon Cytokine Res,2012,32(11):542-547.

相似文献/References:

[1]金力荣,杨麦青,徐洪波,等.TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义[J].医学信息,2022,35(11):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest[J].Medical Information,2022,35(23):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
[2]余 亮,谭自明,张 斌,等.甘露糖结合凝集素基因多态性与结核病易感性关系的研究[J].医学信息,2018,31(13):65.[doi:10.3969/j.issn.1006-1959.2018.13.019]
　YU Liang,TAN Zi-ming,ZHANG Bin,et al.Relationship between Polymorphism of Mannose Binding Lectin Gene and Susceptibility to Tuberculosis[J].Medical Information,2018,31(23):65.[doi:10.3969/j.issn.1006-1959.2018.13.019]
[3]曾 意,汤永红,张 平.CYP2C19基因多态性与复发性缺血性卒中关系的研究[J].医学信息,2022,35(11):22.[doi:10.3969/j.issn.1006-1959.2022.11.007]
　ZENG Yi,TANG Yong-hong,ZHANG Ping.Study on Correlation Between CYP2C19 Gene Polymorphism and Recurrent Ischemic Stroke[J].Medical Information,2022,35(23):22.[doi:10.3969/j.issn.1006-1959.2022.11.007]
[4]管 建,姜娟娟.血清IL-6、IL-10、CRP和PCT水平检测对手足口病早期 合并细菌感染患儿的临床诊断价值[J].医学信息,2018,31(15):146.[doi:10.3969/j.issn.1006-1959.2018.15.047]
　GUAN Jian,JIANG Juan-juan.Clinical Diagnostic Value of Serum Levels of IL-6,IL-10,CRP and PCT in Children with Hand-Foot-and-Mouth Disease Combined with Early Bacterial Infection[J].Medical Information,2018,31(23):146.[doi:10.3969/j.issn.1006-1959.2018.15.047]
[5]甘维桃,曾 凡,冮绍斌.乌司他丁对膝关节置换术后关节炎症及周围肿胀的影响[J].医学信息,2019,32(02):161.[doi:10.3969/j.issn.1006-1959.2019.02.049]
　GAN Wei-tao,ZENG Fan,GANG Shao-bin.Effect of Ulinastatin on Joint Inflammation and Peripheral Swelling after Knee Joint Replacement[J].Medical Information,2019,32(23):161.[doi:10.3969/j.issn.1006-1959.2019.02.049]
[6]吴丕六,汤 磊.PCT、IL-6和CRP水平预测未足月胎膜早破患者并发绒毛膜羊膜炎及新生儿早发性败血症的价值研究[J].医学信息,2019,32(04):163.[doi:10.3969/j.issn.1006-1959.2019.04.054]
　WU Pi-liu,TANG Lei.PCT, IL-6 and CRP Levels Predict the Value of Chorioamnionitis and Early Onset Sepsis in Patients with Premature Rupture of Fetal Membranes[J].Medical Information,2019,32(23):163.[doi:10.3969/j.issn.1006-1959.2019.04.054]
[7]王在川,华 琳.SOD基因多态性与COPD易感性的Meta分析[J].医学信息,2018,31(17):57.[doi:10.3969/j.issn.1006-1959.2018.17.018]
　WANG Zai-chuan,HUA Lin.Meta-analysis of SOD Gene Polymorphism and Susceptibility to COPD[J].Medical Information,2018,31(23):57.[doi:10.3969/j.issn.1006-1959.2018.17.018]
[8]陈恒安,胡 海,刘金龙,等.股骨头坏死骨髓IL-6表达与骨髓水肿分级的相关性研究[J].医学信息,2019,32(03):65.[doi:10.3969/j.issn.1006-1959.2019.03.021]
　CHEN Heng-an,HU Hai,LIU Jin-long,et al.Correlation between Bone Marrow IL-6 Expression and Grade of Bone Marrow Edema in Osteonecrosis of Femoral Head[J].Medical Information,2019,32(23):65.[doi:10.3969/j.issn.1006-1959.2019.03.021]
[9]邹光美,黄朝任.白介素6基因多态性与多种疾病的相关性研究[J].医学信息,2022,35(12):61.[doi:10.3969/j.issn.1006-1959.2022.12.014]
　ZOU Guang-mei,HUANG Chao-ren.Correlation Between Interleukin 6 Gene Polymorphism and Various Diseases[J].Medical Information,2022,35(23):61.[doi:10.3969/j.issn.1006-1959.2022.12.014]
[10]褚福行,李珊珊,李思琪,等.慢性牙周炎伴肥胖患者血清中IL-6、IL-18表达水平的研究[J].医学信息,2019,32(01):92.[doi:10.3969/j.issn.1006-1959.2019.01.028]
　CHU Fu-xing,LI Shan-shan,LI Si-qi,et al.Study on the Expression Levels of IL-6 and IL-18 in Serum of Patients with Chronic Periodontitis and Obesity[J].Medical Information,2019,32(23):92.[doi:10.3969/j.issn.1006-1959.2019.01.028]

更新日期/Last Update: 1900-01-01