[1]饶冬萍,范敏珍,梁卉薇.抑郁症患者血清皮质醇水平与认知功能的相关性分析[J].医学信息,2021,34(04):1-5.[doi:10.3969/j.issn.1006-1959.2021.04.001]
　RAO Dong-ping,FAN Min-zhen,LIANG Hui-wei.Correlation Analysis of Serum Cortisol Level and Cognitive Function in Patients with Depression[J].Medical Information,2021,34(04):1-5.[doi:10.3969/j.issn.1006-1959.2021.04.001]
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抑郁症患者血清皮质醇水平与认知功能的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
1-5
栏目:
出版日期:
2021-02-15

文章信息/Info

Title:
Correlation Analysis of Serum Cortisol Level and Cognitive Function in Patients with Depression
文章编号:
1006-1959（2021）04-0001-05
作者:
饶冬萍; 范敏珍; 梁卉薇
（广州医科大学附属脑科医院精神科，广东 广州 510370）
Author(s):
RAO Dong-ping; FAN Min-zhen; LIANG Hui-wei
(Department of Psychiatry,Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,Guangdong,China)
关键词:
抑郁症; 皮质醇; 认知功能; 抑郁症状
Keywords:
Depression; Cortisol; Cognitive function; Depressive symptoms
分类号:
R749.4
DOI:
10.3969/j.issn.1006-1959.2021.04.001
文献标志码:
A
摘要:
目的 探讨抑郁症患者血清皮质醇水平与认知功能的关系。方法 选取2018年3月~2019年12月于广州医科大学附属脑科医院门诊或住院部的首次发作的抑郁症患者117例作为研究对象，根据汉密尔顿抑郁量表（HAMD）结果分为无精神病性症状组和有精神病性症状组，均进行言语流畅性测验（动物数）、威斯康星卡片分类测验（WCST）、汉诺塔测验、连线测验A和B评估认知功能测评及血清皮质醇水平检测，比较两组一般资料及神经心理测验成绩，分析抑郁症患者神经心理测验与血清皮质醇水平、HAMD总分及因子分的关系及无精神病性症状组和有精神病性症状组神经心理测验与血清皮质醇水平、HAMD总分及因子分的关系。结果 有精神病性症状组共39例，其血清皮质醇水平高于无精神病性症状组（P＜0.05）。相关性分析显示：①抑郁症患者血清皮质醇水平与各项神经心理测验成绩均无相关性（P＞0.05）；连线测验A时间与HAMD总分及阻滞因子呈正相关，WCST总错误数、随机错误数与HAMD睡眠障碍因子分呈正相关，汉诺塔测验完成任务数与HAMD总分、焦虑/躯体化因子分、阻滞因子分呈负相关，平均执行时间与HAMD总分、阻滞因子分呈正相关，汉诺塔总得分与HAMD总分、焦虑/躯体化因子分、阻滞因子分呈负相关（P＜0.05）；进一步控制HAMD量表分的影响，血清皮质醇水平与各项神经心理测验成绩之间仍均无相关性（P＞0.05）。②有精神病性症状组血清皮质醇水平与WCST分类数呈负相关，与WCST的总错误数、持续错误数呈正相关（P＜0.05）；焦虑/躯体化因子分与WCST分类数呈负相关），与WCST的总错误数、持续错误数呈正相关（P＜0.05）；进一步控制HAMD量表分的影响，血清皮质醇水平与WCST分类数、总错误数无相关性，与持续错误数呈正相关（P＜0.05）；控制血清皮质醇的影响，焦虑/躯体化因子分与WCST分类数、总错误数、持续错误数无相关性（P＞0.05）。③无精神病性症状组中血清皮质醇水平与各项神经心理测验成绩均无相关性（P＞0.05）；阻滞因子分与WCST分类数、汉诺塔测验完成任务数及总得分呈负相关，与汉诺塔测验平均执行时间呈正相关（P＜0.05）；进一步控制HAMD量表分的影响，血清皮质醇水平与各项神经心理测验成绩仍无相关性（P＞0.05）。结论 有精神病性症状的抑郁症患者血清皮质醇水平较不伴有精神病性抑郁症状者高，认知灵活性与血清皮质醇水平的关系较抑郁症状更紧密。
Abstract:
Objective To explore the relationship between serum cortisol level and cognitive function in patients with depression.Methods 117 cases of first-onset depression patients who were in the outpatient or inpatient department of the Brain Hospital of Guangzhou Medical University from March 2018 to December 2019 were selected as the research objects.According to the results of the Hamilton Depression Scale (HAMD), it was divided into a group without psychotic symptoms and a group with psychotic symptoms. Speech fluency test (number of animals), Wisconsin Card Sorting Test (WCST), Tower of Hanoi test, and connection test are performed. A and B assess cognitive function assessment and serum cortisol level detection,The general data and neuropsychological test scores of the two groups were compared, and the relationship between neuropsychological test and serum cortisol level, HAMD total score and factor score in patients with depression, as well as neuropsychological test and serum cortex in the group without psychotic symptoms and the group with psychotic symptoms The relationship between alcohol level, HAMD total score and factor score.Results There were 39 patients in the psychotic symptom group, and their serum cortisol levels were higher than those in the non-psychotic symptom group (P<0.05).Correlation analysis showed that ① there was no correlation between serum cortisol levels in patients with depression and various neuropsychological test scores (P>0.05);Connected test A time was positively correlated with HAMD total score and block factor, WCST total error number, random error number and HAMD sleep disturbance factor score are positively correlated, Tower of Hanoi test completed tasks and HAMD total score,Anxiety/Somatization factor score and block factor score are negatively correlated, and the average execution time was positively correlated with the total HAMD score and block factor score.The total score of Tower of Hanoi was negatively correlated with the total score of HAMD, the score of anxiety/somatization factor and the score of blocking factor (P<0.05);Further controlling the influence of HAMD scale scores, there was still no correlation between serum cortisol levels and the results of various neuropsychological tests (P>0.05).②The level of serum cortisol in the group with psychotic symptoms was negatively correlated with the WCST classification number, and positively correlated with the total number of errors and the number of persistent errors in WCST (P<0.05);Anxiety/Somatization factor score was negatively correlated with the number of WCST classifications, and positively correlated with the total number of errors and the number of persistent errors in WCST (P<0.05);To further control the impact of HAMD scale scores, serum cortisol levels had no correlation with the number of WCST classifications and total errors, but were positively correlated with the number of persistent errors (P<0.05);Controlling the influence of serum cortisol, the anxiety/somatization factor score had no correlation with the number of WCST categories, the number of total errors, and the number of persistent errors (P>0.05).

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更新日期/Last Update: 1900-01-01