[1]王岳宸.度洛西汀治疗老年抑郁症的效果及对患者血清BDNF、5-TH、IL-18表达的影响[J].医学信息,2021,34(04):6-8.[doi:10.3969/j.issn.1006-1959.2021.04.002]
　WANG Yue-chen.The Effect of Duloxetine in the Treatment of Senile Depression and Its Influence on the Expression of Serum BDNF,5-TH and IL-18 in Patients[J].Medical Information,2021,34(04):6-8.[doi:10.3969/j.issn.1006-1959.2021.04.002]
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度洛西汀治疗老年抑郁症的效果及对患者血清BDNF、5-TH、IL-18表达的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
6-8
栏目:
出版日期:
2021-02-15

文章信息/Info

Title:
The Effect of Duloxetine in the Treatment of Senile Depression and Its Influence on the Expression of Serum BDNF,5-TH and IL-18 in Patients
文章编号:
1006-1959（2021）04-0006-03
作者:
王岳宸
（佳木斯市中心医院药剂科，黑龙江 佳木斯 154002）
Author(s):
WANG Yue-chen
(Department of Pharmacy,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
度洛西汀; 抑郁症; BDNF; 5-TH; IL-18
Keywords:
Duloxetine; Depression; BDNF; 5-TH; IL-18
分类号:
R749.4
DOI:
10.3969/j.issn.1006-1959.2021.04.002
文献标志码:
A
摘要:
目的 分析度洛西汀治疗老年抑郁症的效果及对患者血清BDNF、5-TH、IL-18表达的影响。方法 选取2018年1月~2019年12月于本院诊治的老年抑郁症患者90例，采用随机数字表法分成对照组和观察组，每组45例。对照组给予舍曲林治疗，观察组给予度洛西汀治疗。比较两组抑郁状态评分、临床疗效、血清学指标和不良反应。结果 两组抑郁状态评分均降低，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组总有效率为95.56%，高于对照组的80.00%，差异有统计学意义（P＜0.05）；两组血清BDNF、5-TH水平均升高，IL-18水平均降低，且观察组血清BDNF、5-TH水平高于对照组，IL-18水平低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应总发生率为13.33%，低于对照组的31.11%，差异有统计学意义（P＜0.05）。结论 度洛西汀治疗老年抑郁症效果确切，可减轻抑郁症状，上调血清BDNF、5-TH表达，下调IL-18表达，安全有效。
Abstract:
Objective To analyze the effect of duloxetine in the treatment of senile depression and its influence on the expression of serum BDNF, 5-TH and IL-18 in patients.Methods A total of 90 elderly depression patients who were diagnosed and treated in our hospital from January 2018 to December 2019 were selected and divided into a control group and an observation group using a random number table method, with 45 cases in each group.The control group was given sertraline treatment, and the observation group was given duloxetine treatment. The depression status scores, clinical efficacy, serological indicators and adverse reactions were compared between the two groups.Results The scores of depression in the two groups were reduced, and the observation group was lower than the control group, the difference was statistically significant (P＜0.05);The total effective rate of the observation group was 95.56%, which was higher than 80.00% of the control group,the difference was statistically significant (P＜0.05);The serum BDNF and 5-TH levels of the two groups increased, and the IL-18 levels decreased. The observation group’s serum BDNF and 5-TH levels were higher than those of the control group, and the IL-18 levels were lower than the control group,the difference was statistically significant(P＜0.05);The total incidence of adverse reactions in the observation group was 13.33%, which was lower than 31.11% in the control group,the difference was statistically significant(P＜0.05).Conclusion Duloxetine is effective in treating senile depression. It can relieve depressive symptoms, up-regulate the expression of serum BDNF and 5-TH, and down-regulate the expression of IL-18, which is safe and effective.

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更新日期/Last Update: 1900-01-01