[1]覃泽东,夏玉梅,陈 莉,等.多发性骨髓瘤合并颅内浆细胞瘤的临床及影像学特点分析[J].医学信息,2021,34(05):111-113.[doi:10.3969/j.issn.1006-1959.2021.05.031]
　QIN Ze-dong,XIA Yu-mei,CHEN Li,et al.Analysis of Clinical and Imaging Characteristics of Multiple Myeloma Combined with Intracranial Plasmacytoma[J].Medical Information,2021,34(05):111-113.[doi:10.3969/j.issn.1006-1959.2021.05.031]
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多发性骨髓瘤合并颅内浆细胞瘤的临床及影像学特点分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年05期
页码:
111-113
栏目:
临床研究
出版日期:
2021-03-01

文章信息/Info

Title:
Analysis of Clinical and Imaging Characteristics of Multiple Myeloma Combined with Intracranial Plasmacytoma
文章编号:
1006-1959（2021）05-0111-03
作者:
覃泽东; 夏玉梅; 陈 莉; 等
（1.西昌市人民医院肿瘤科，四川 西昌 615000； 2.攀枝花学院附属医院肿瘤科，四川 攀枝花 617000）
Author(s):
QIN Ze-dong; XIA Yu-mei; CHEN Li; et al.
(1.Department of Oncology,Xichang People’s Hospital,Xichang 615000,Sichuan,China; 2.Department of Oncology,Affiliated Hospital of Panzhihua University,Panzhihua 617000,Sichuan,China)
关键词:
多发性骨髓瘤; 浆细胞瘤; MRI
Keywords:
Multiple myeloma; Plasmacytoma; MRI
分类号:
R551.3
DOI:
10.3969/j.issn.1006-1959.2021.05.031
文献标志码:
A
摘要:
目的 探讨多发性骨髓瘤（MM）合并颅内浆细胞瘤的临床及影像学特点。方法 回顾性分析2010年1月~2020年12月经病理证实的6例MM合并颅内浆细胞瘤患者的临床资料及影像学资料，分析临床表现及影像学表现。结果 除MM常见临床表现外，患者多合并头痛、呕吐及局灶性神经功能受损的症状和体征等,部分患者无脑部症状或仅有轻微认知功能改变。CT平扫颅内浆细胞瘤多表现为均匀一致的稍高密度影，MRI平扫呈稍长T2稍长T1信号，增强扫描明显强化，部分患者伴有临近颅骨骨质破坏。结论 MM合并颅内浆细胞瘤发生率相对较低，但预后较差，部分颅内浆细胞瘤早期无症状极易漏诊，另有部分颅内浆细胞瘤极易误诊为脑膜瘤从而进行不必要的手术治疗，临床工作中应提高对其的认识。
Abstract:
Objective To investigate the clinical and imaging characteristics of multiple myeloma (MM) combined with intracranial plasmacytoma.Methods The clinical data and imaging data of 6 patients with multiple myeloma combined with intracranial plasmacytoma confirmed by pathology from January 2010 to December 2020 were retrospectively analyzed, and the clinical and imaging findings were analyzed.Results In addition to the common clinical manifestations of MM, patients often had symptoms and signs of headache, vomiting, and focal neurological impairment. Some patients had no brain symptoms or only slight cognitive changes. CT plain scan intracranial plasmacytoma mostly showed uniform and slightly higher density shadows. MRI plain scan showed slightly longer T2 and longer T1 signals, which were significantly enhanced by enhanced scan. Some patients had adjacent skull bone destruction.Conclusion The incidence of MM combined with intracranial plasmacytoma is relatively low, but the prognosis is poor. Some intracranial plasmacytomas are asymptomatic and easily missed, and some intracranial plasmacytomas are easily misdiagnosed as meningiomas and therefore unnecessary. In clinical work, we should raise our awareness of surgical treatment.

参考文献/References:

[1]Moreau P,Masszi T,Grzasko N,et al.Oral Ixazomib,Lenalidomide,and Dexamethasone for Multiple Myeloma[J].New England Journal of Medicine,2016,374(17):1621. [2]Lazzarino M.Incidence,presenting features and outcome of extramedullary disease in multiple myeloma:a longitudinal study on 1003 consecutive patients[J].Annals of Oncology Official Journal of the European Society for Medical Oncology,2010,21(2):325. [3]Kumar SK,Callander NS,Alsina M,et al.NCCN Guidelines Insights:Multiple Myeloma,Version 3.2018[J].J Natl Compr Canc Netw,2018,16(1):11-20. [4]Egerer E,Siemonsen S,Erbguth F.Acute diseases of the brain and heart : A reciprocal culprit-victim relationship[J].Med Klin Intensivmed Notfmed,2018,113(6):456-463. [5]Chen CI,Masih-Khan E,Jiang H,et al.Central nervous system involvement with multiple myeloma:long term survival can be achieved with radiation,intrathecal chemotherapy,and immunomodulatory agents[J].British Journal of Haematology,2013,162(4):483-488. [6]Lasocki A,Gangatharan S,Gaillard F,et al.Intracranial involvement by multiple myeloma[J].Clin Radiol,2015,70(8):890-897. [7]Wilberger AC,Prayson RA.Intracranial Involvement by Plasma Cell Neoplasms[J].Am J Clin Pathol,2016,146(2):156-162. [8]Jun BK,Ho B,Yuen T.Intracranial multiple myeloma with intraparenchymal involvement: Case report and literature review[J].J Clin Neurosci,2019(59):335-337. [9]Okamoto K,Ito J,Furusawa T,et al.Solitary plasmacytomas of the occipital bone:a report of two cases[J].European Radiology,1997,7(4):503. [10]Sahin F,Saydam G,Ertan Y,et al.Dural plasmacytoma mimicking meningioma in a patient with multiple myeloma[J].J Clin Neurosci,2006,13(2):259-261. [11]Hasturk AE,Basmaci M,Erten F,et al.Solitary Dural Plasmacytoma Mimicking Meningioma and Invading Calvarium[J].Journal of Craniofacial Surgery,2013,24(2):E175-E177. [12]Azarpira N,Noshadi P,Pakbaz S,et al.Dural Plasmacytoma Mimicking Meningioma[J].Turkish Neurosurgery,2014,24(3):403-405. [13]Rutherford SA,Leach PA,Richardson PL.Solitary skull vault plasmacytoma masquerading as an extradural haematoma[J].Acta Neurochir (Wien),2004,146(8):863-864.

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更新日期/Last Update: 1900-01-01