[1]喻 明,李 莹,王秀容.甲泼尼龙联合丙种球蛋白治疗抗NMDAR型脑炎的疗效及对患者精神症状的影响[J].医学信息,2021,34(15):159-161,165.[doi:10.3969/j.issn.1006-1959.2021.15.044]
　YU Ming,LI Ying,WANG Xiu-rong.Efficacy of Methylprednisolone Combined with Gamma Globulin in the Treatment of Anti-NMDAR Encephalitis and Its Effect on Patient’s Mental Symptoms[J].Medical Information,2021,34(15):159-161,165.[doi:10.3969/j.issn.1006-1959.2021.15.044]
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甲泼尼龙联合丙种球蛋白治疗抗NMDAR型脑炎的疗效及对患者精神症状的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年15期
页码:
159-161,165
栏目:
药物与临床
出版日期:
2021-08-01

文章信息/Info

Title:
Efficacy of Methylprednisolone Combined with Gamma Globulin in the Treatment of Anti-NMDAR Encephalitis and Its Effect on Patient’s Mental Symptoms
文章编号:
1006-1959（2021）15-0159-04
作者:
喻 明; 李 莹; 王秀容
（遂宁市中心医院神经内科，四川 遂宁 629000）
Author(s):
YU Ming; LI Ying; WANG Xiu-rong
(Department of Neurology,Suining Central Hospital,Suining 629000,Sichuan,China)
关键词:
抗NMDAR脑炎; 甲泼尼龙; 丙种球蛋白; 癫痫; 认知功能
Keywords:
Anti-NMDAR encephalitis; Methylprednisolone; Gamma globulin; Epilepsy; Cognitive function
分类号:
R72
DOI:
10.3969/j.issn.1006-1959.2021.15.044
文献标志码:
A
摘要:
目的 探讨甲泼尼龙联合丙种球蛋白治疗抗NMDAR型脑炎的临床疗效。方法 回顾性分析2015年9月~2019年12月于我院确诊的抗NMDAR型脑炎患者92例，根据患者住院期间使用的治疗方案，将患者分为甲泼尼龙组（MPS组）30例、丙种球蛋白组（IG组）31例、甲泼尼龙联合丙种球蛋白组（MPS+IG组）32例；比较三组治疗后90 d内临床疗效、mRs评分、MMSE评分、并发症及死亡率。结果 三组治疗总有效率比较，差异有统计学意义（P＜0.05），其中MPS+IG组总有效率高于IG组和MPS组（P＜0.05）；三组治疗后90 d mRs评分比较，差异有统计学意义（P＜0.05），其中MPS+IG组mRs评分低于IG组和MPS组（P＜0.05）；三组治疗后15、30、90 d MMSE评分比较，差异有统计学意义（P＜0.05），其中MPS+IG组MMSE评分高于MPS组和IG组（P＜0.05）；三组并发症发生率及死亡率比较，差异有统计学意义（P＜0.05），其中MPS+IG组并发症发生率及死亡率均低于MPS组和IG组（P＜0.05）。结论 甲泼尼龙联合丙种球蛋白治疗抗NMDAR型脑炎比单用甲泼尼龙或丙种球蛋白临床效率好，mRS评分更低，MMSE评分更高，患者并发症及死亡发生率更低，值得临床应用。
Abstract:
Objective To investigate the clinical efficacy of methylprednisolone combined with gamma globulin in the treatment of anti-NMDAR encephalitis.Methods A retrospective analysis of 92 patients with anti-NMDAR encephalitis diagnosed in our hospital from September 2015 to December 2019.According to the treatment plan used during the hospitalization, the patients were divided into methylprednisolone treatment group (MPS group) with 30 cases, gamma globulin treatment group (IG group) with 31 cases, methylprednisolone combined with gamma globulin treatment group (MPS+ IG group) 32 cases;The clinical efficacy, mRs score, MMSE score, complications and mortality within 90 d after treatment were compared among the three groups.Results The total effective rate of the three groups was compared,the difference was statistically significant (P＜0.05).The total effective rate of MPS+IG group was higher than that of IG group and MPS group (P＜0.05);The 90 d mRs scores of the three groups were compared,the difference was statistically significant(P＜0.05).The mRs score of MPS+IG group was lower than that of IG group and MPS group (P＜0.05);There was a statistically significant difference in the MMSE scores of the three groups at 15, 30, and 90 d after treatment (P＜0.05).Among them, the MMSE score of the MPS+IG group was higher than that of the MPS group and the IG group (P＜0.05);The complication rate and mortality of the three groups were compared,the difference was statistically significant(P＜0.05).The incidence of complications and mortality in the MPS+IG group were lower than those in the MPS and IG groups (P<0.05).Conclusion Methylprednisolone combined with gamma globulin is more effective than methylprednisolone or gamma globulin in the treatment of anti-NMDAR encephalitis. The mRS score is lower, the MMSE score is higher, and the incidence of complications and death is lower. It is worthy of clinical practice application.

参考文献/References:

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更新日期/Last Update: 1900-01-01