[1]张莹莹,郭绪昆,刘 寅.氯吡格雷药代动力学特点及其在心血管疾病中的临床应用[J].医学信息,2021,34(20):45-49.[doi:10.3969/j.issn.1006-1959.2021.20.011]
 ZHANG Ying-ying,GUO Xu-kun,LIU Yin.Pharmacokinetic Characteristics of Clopidogrel and the Clinical Application in Cardiovascular Diseases[J].Medical Information,2021,34(20):45-49.[doi:10.3969/j.issn.1006-1959.2021.20.011]
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氯吡格雷药代动力学特点及其在心血管疾病中的临床应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年20期
页码:
45-49
栏目:
综述
出版日期:
2021-10-20

文章信息/Info

Title:
Pharmacokinetic Characteristics of Clopidogrel and the Clinical Application in Cardiovascular Diseases
文章编号:
1006-1959(2021)20-0045-05
作者:
张莹莹郭绪昆刘 寅
天津市胸科医院心内科/天津市心血管病研究所,天津 300222
Author(s):
ZHANG Ying-yingGUO Xu-kunLIU Yin
Department of Cardiology,Tianjin Chest Hospital/Tianjin Institute of Cardiovascular Disease,Tianjin 300222,China
关键词:
冠心病氯吡格雷药代动力学基因多态性
Keywords:
Coronary heart diseaseClopidogrelPharmacokineticGene polymorphism
分类号:
R54;R969
DOI:
10.3969/j.issn.1006-1959.2021.20.011
文献标志码:
A
摘要:
冠心病为威胁人类健康的重大疾病,阿司匹林联合P2Y12受体拮抗剂氯吡格雷的双联抗血小板治疗(DAPT)在心血管疾病的抗栓治疗中发挥了非常重要的作用。药代动力学研究显示,氯吡格雷为无活性的前体药物,需要经一系列的酶降解转化才能发挥抗血小板活性。而编码关键酶的基因存在多态性,间接影响了氯吡格雷的药效。因此,在临床实践中选择最为合理的P2Y12受体拮抗剂至关重要。本文主要从三种常见P2Y12受体拮抗剂的药代动力学、影响氯吡格雷药代动力学的遗传决定因素及氯吡格雷临床治疗策略分析作一综述,以期为临床合理用药提供参考。
Abstract:
Coronary heart disease is a major disease threatening human health. Aspirin combined with clopidogrel, a P2Y12 receptor antagonist, plays a very important role in the anti-thrombotic therapy of cardiovascular diseases. Pharmacokinetic studies show that clopidogrel is an inactive precursor drug that requires a series of enzymatic degradation and transformation to exert antiplatelet activity. The polymorphisms of genes encoding key enzymes indirectly affected the efficacy of clopidogrel. Therefore, it is very important to select the most reasonable P2Y12 receptor antagonist in clinical practice. In this review, the pharmacokinetics of three common P2Y12 receptor antagonists, the genetic determinants that influence the pharmacokinetics of clopidogrel, and the analysis of clinical treatment strategies for clopidogrel are reviewed in order to provide references for clinical rational drug use.

参考文献/References:

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更新日期/Last Update: 1900-01-01