[1]李芳芳,于 佳.重组人干扰素α-2b雾化治疗儿童呼吸道病毒感染性疾病的临床效果[J].医学信息,2021,34(23):120-122.[doi:10.3969/j.issn.1006-1959.2021.23.035]
　LI Fang-fang,YU Jia.Clinical Effect of Recombinant Human Interferon α-2b Atomization in the Treatment of Children with Respiratory Viral Infectious Diseases[J].Medical Information,2021,34(23):120-122.[doi:10.3969/j.issn.1006-1959.2021.23.035]
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重组人干扰素α-2b雾化治疗儿童呼吸道病毒感染性疾病的临床效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
120-122
栏目:
论著
出版日期:
2021-12-01

文章信息/Info

Title:
Clinical Effect of Recombinant Human Interferon α-2b Atomization in the Treatment of Children with Respiratory Viral Infectious Diseases
文章编号:
1006-1959（2021）23-0120-03
作者:
李芳芳; 于 佳
（天津市滨海新区海滨人民医院儿科1，消化内科2，天津 300280）
Author(s):
LI Fang-fang; YU Jia
(Department of Pediatrics1,Department of Gastroenterology2,Haibin People’s Hospital of Tianjin Binhai New Area,Tianjin 300280,China)
关键词:
病毒感染; 呼吸道疾病; 重组人干扰素α-2b; 免疫球蛋白
Keywords:
Virus infection; Respiratory diseases; Recombinant human interferon α-2b; Immunoglobulin
分类号:
R511.7
DOI:
10.3969/j.issn.1006-1959.2021.23.035
文献标志码:
A
摘要:
目的 探究重组人干扰素α-2b（rhIFNα-2b）雾化治疗儿童呼吸道病毒感染性疾病（RVI）的临床效果。方法 选取2019年3月-2020年12月我院儿科收治的80例RVI患儿为研究对象，采用随机数字表法分为对照组和观察组，各40例。对照组行常规治疗，观察组则在其基础上加用rhIFNα-2b雾化治疗。比较两组临床疗效、症状改善时间、炎性指标[嗜酸性粒细胞阳离子蛋白（ECP）及嗜酸性粒细胞（EOS）]、免疫球蛋白指标[免疫球蛋白G（IgG）、免疫球蛋白A（IgA）]、药物不良反应以及病毒感染复发率。结果 观察组治疗总有效率较对照组高（P＜0.05）；观察组的症状改善时间（退热时间、止咳时间、啰音消失时间）均短于对照组（P＜0.05）；治疗后，两组ECP、EOS指标低于治疗前，IgG、IgA指标高于治疗前，且观察组ECP、EOS指标低于对照组，IgG、IgA指标高于对照组，差异有统计学意义（P＜0.05）；两组药物不良反应发生率比较，差异无统计学意义（P＞0.05）；治疗后3个月观察组未发现感染复发病例，而对照组的感染复发率为10.00%，差异有统计学意义（P＜0.05）。结论 rhIFNα-2b雾化治疗儿童RVI疗效肯定，可缩短患儿的症状改善时间，控制其炎性表达，同时改善机体免疫应答，降低复发风险，安全可行。
Abstract:
Objective To explore the clinical effect of recombinant human interferon α-2b （rhIFNα-2b） atomization in the treatment of children with respiratory viral infectious (RVI).Methods A total of 80 children with RVI admitted to our hospital from March 2019 to December 2020 were selected as the research objects, and they were divided into control group and observation group by random number table method, with 40 cases in each group. The control group was treated with routine treatment, while the observation group was treated with rhIFNα-2b atomization on the basis of routine treatment. The clinical efficacy, symptom improvement time, inflammatory indexes [eosinophil cationic protein (ECP) and eosinophils (EOS)], immunoglobulin indexes [immunoglobulin G (IgG), immunoglobulin A (IgA) ], adverse drug reactions and viral infection recurrence rates were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group (P<0.05). The symptom improvement time (antipyretic time, cough relieving time and rale disappearance time) in the observation group was shorter than that in the control group (P<0.05). After treatment, the ECP and EOS of the two groups were lower than those before treatment, IgG and IgA were higher than those before treatment, ECP and EOS of the observation group were lower than those of the control group, IgG and IgA were higher than those of the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). Three months after treatment, no recurrence of infection was found in the observation group, while the recurrence rate of infection in the control group was 10.00%, and the difference was statistically significant (P<0.05).Conclusion The effect of rhIFNα-2b atomization in the treatment of children with RVI is definite， which can shorten the time of symptom improvement in children， control its inflammatory expression， improve the immune response of the body, and reduce the risk of recurrence. It is safe and feasible.

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更新日期/Last Update: 1900-01-01