[1]陈 茁,杜义斌,钱艳平.绝经年龄与女性急性脑梗死患者NIHSS评分的相关性研究[J].医学信息,2022,35(04):124-126.[doi:10.3969/j.issn.1006-1959.2022.04.031]
　CHEN Zhuo,DU Yi-bin,QIAN Yan-ping.Correlation Between Menopausal Age and NIHSS Score in Female Patientswith Acute Cerebral Infarction[J].Medical Information,2022,35(04):124-126.[doi:10.3969/j.issn.1006-1959.2022.04.031]
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绝经年龄与女性急性脑梗死患者NIHSS评分的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
124-126
栏目:
临床研究
出版日期:
2022-02-15

文章信息/Info

Title:
Correlation Between Menopausal Age and NIHSS Score in Female Patientswith Acute Cerebral Infarction
文章编号:
1006-1959（2022）04-0124-03
作者:
陈 茁; 杜义斌; 钱艳平
云南省中医医院老年病科，云南 昆明 650021
Author(s):
CHEN Zhuo; DU Yi-bin; QIAN Yan-ping
Department of Geriatrics,Yunnan Traditional Chinese medicine Hospital,Kunming 650021,Yunnan,China
关键词:
绝经年龄; 急性脑梗死; 女性; NIHSS评分
Keywords:
Menopausal age; Acute cerebral infarction; Female;  NIHSS score
分类号:
R743.33
DOI:
10.3969/j.issn.1006-1959.2022.04.031
文献标志码:
A
摘要:
目的 探讨绝经年龄（MA）与女性急性脑梗死患者NIHSS评分的关系。方法 选取2017年6月1日-2020年6月1日云南省中医医院神经内科及老年病区收治的434例绝经后女性急性脑梗死患者的临床资料，根据绝经年龄分为MA＜46岁组56例、46≤MA≤52岁组288例和MA＞52岁组90例。收集患者一般资料，评估NIHSS评分，分析绝经年龄和NIHSS评分的相关性。结果 MA＜46岁组及46≤MA≤52岁组大动脉粥样硬化型及小动脉闭塞型患者多于MA＞52岁组，MA＞52岁组心源性栓塞型、小动脉闭塞型患者多于MA＜46岁组及46≤MA≤52岁组，差异有统计学意义（P＜0.05）；MA＜46岁组脑梗死患者NIHSS评分高于46≤MA≤52岁组和MA＞52岁组，46≤MA≤52岁组脑梗死患者NIHSS评分高于MA＞52岁组，差异有统计学意义（P＜0.05）；绝经年龄和NIHSS评分呈负相关（r=-0.875，P=0.000）。结论 绝经年龄与女性急性脑梗死患者NIHSS评分呈负相关，绝经年龄越早的女性脑梗死患者，神经功能缺损程度越重。
Abstract:
Objective To investigate the relationship between menopausal age(MA) and NIHSS score in female patients with acute cerebral infarction.Methods A total of 434 postmenopausal women with acute cerebral infarction admitted to the Department of Neurology and geriatrics of Yunnan Provincial Hospital of Traditional Chinese Medicine from June 1, 2017 to June 1, 2020 were selected. According to menopausal age, they were divided into MA<46 years old group (n=56), 46 years old group≤MA≤52 years old group (n=288) and MA>52 years old group (n=90). The general data of patients were collected, the NIHSS score was evaluated, and the correlation between menopause age and NIHSS score was analyzed.Results Patients with large artery atherosclerosis and small artery occlusion in MA<46 years old group and 46 years old group≤MA≤52 years old group were more than those in MA>52 years old group, patients with cardiogenic embolism and small artery occlusion in MA>52 years old group were more than those in MA<46 years old group and 46 years old group≤MA≤52 years old group, and the difference was statistically significant (P<0.05). NIHSS score of patients with cerebral infarction in MA<46 years old group was higher than that in 46 years old group≤MA≤52 years old group and MA>52 years old group, and NIHSS score of patients with cerebral infarction in 46 years old group≤MA≤52 years old group was higher than that in MA>52 years old group, and the difference was statistically significant (P<0.05). There was a negative correlation between menopause age and NIHSS score (r=-0.875, P=0.000).Conclusion The menopause age is negatively correlated with the NIHSS score of female patients with acute cerebral infarction. The earlier the age of menopause is, the more severe the neurological deficit is.

参考文献/References:

[1]Zhang W,Zhang X.Correlation between the youth cerebral infarction in different TOAST classifications and high homocysteine[J].Cell Biochem Biophys,2015,71(1):39-42.[2]Donkor ES.Stroke in the 21st century: A snapshot of the burden, epidemiology, and quality of life[J].Stroke Res Treat,2018(2018):3238165.[3]湛彦强,许峰,邢变枝,等.急性脑梗死患者脑微出血的危险因素分析[J].神经损伤与功能重建,2019,14(2):15-17,21.[4]Wu S,Wu B,Liu M,et al.Stroke in China: advances and challenges in epidemiology, prevention, and management[J].The Lancet Neurology,2019,18(4):394-405.[5]吴川杰,马青峰,陈健,等.用组织窗代替传统时间窗指导急性脑梗死的再灌注治疗[J].中国卒中杂志,2018,13(8):846-852.[6]Labrie F,Bélanger A,Pelletier G,et al.Science of intracrinology in postmenopausal women[J].Menopause,2017,24(6):702-712.[7]Mansoor H,Elgendy IY,Segal R,et al.Duration of reproductive years and the risk of cardiovascular and cerebrovascular events in older women: insights from the National Health and Nutrition Examination Survey[J].Journal of Women’s Health,2017,26(10):1047-1052.[8]Cosman F,Crittenden DB,Adachi JD,et al.Romosozumab treatment in postmenopausal women with osteoporosis[J].New England Journal of Medicine,2016,375(16):1532-1543.[9]Streb J,Glanowska I,Streb A,et al.The relationship between breast cancer treatment, tumour type and vitamin D level in pre-and postmenopausal women[J].Neuroendocrinology Letters,2017,38(6):437-440.[10]Jacobson LT,Hade EM,Collins TC,et al.Breastfeeding history and risk of stroke among parous postmenopausal women in the Women’s Health Initiative[J].Journal of the American Heart Association,2018,7(17):e008739.[11]彭斌,刘鸣,崔丽英.与时俱进的新指南——《中国急性缺血性脑卒中诊治指南2018》解读[J].中华神经科杂志,2018.[12]Xu X,Li C,Wan T,et al.Risk factors for hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: a retrospective single-center study[J].World Neurosurgery,2017(101):155-160.[13]陈婉莹,樊嘉欣,姚庆龄,等.腔隙性脑梗死患者发生急性脑梗死和急性脑出血的危险因素比较[J].卒中与神经疾病,2020,27(1):96-99.[14]Song L,Shen L,Li H,et al.Age at natural menopause and hypertension among middle-aged and older Chinese women[J].Journal of Hypertension,2018,36(3):594-600.[15]申丽君.产次,绝经年龄与女性慢性病的相关性研究[D].武汉:华中科技大学,2017.[16]Yu CH,Kor CT,Weng SC,et al.Symptomatic menopausal transition and risk of subsequent stroke[J].Peer J,2019(7):e7964.[17]Henderson VW,John JAS,Hodis HN,et al.Cognitive effects of estradiol after menopause: a randomized trial of the timing hypothesis[J].Neurology,2016,87(7):699-708.[18]Miller VM,Naftolin F,Asthana S,et al.The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?[J].Menopause,2019,26(9):1071-1084.[19]Fortini F,Dalla Sega FV,Caliceti C,et al.Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway[J].The Journal of Steroid Biochemistry and Molecular Biology,2019(189):87-100.[20]Iorga A,Cunningham CM,Moazeni S,et al.The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy[J].Biology of Sex Differences,2017,8(1):1-16.

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更新日期/Last Update: 1900-01-01