[1]刘明明,黄仕豪.盐酸羟考酮缓释片和硫酸吗啡缓释片对结直肠癌重度疼痛患者的效果及对炎症因子水平和免疫指标的影响[J].医学信息,2022,35(21):134-136.[doi:10.3969/j.issn.1006-1959.2022.21.035]
　LIU Ming-ming,HUANG Shi-hao.Effect of Oxycodone Hydrochloride Prolonged-release Tablets and Morphine Sulfate Prolonged-release Tablets on Patients with Severe Pain of Colorectal Cancer,Levels of Inflammatory Factors and Immune Indexes[J].Journal of Medical Information,2022,35(21):134-136.[doi:10.3969/j.issn.1006-1959.2022.21.035]
点击复制

盐酸羟考酮缓释片和硫酸吗啡缓释片对结直肠癌重度疼痛患者的效果及对炎症因子水平和免疫指标的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年21期
页码:
134-136
栏目:
药物与临床
出版日期:
2022-11-01

文章信息/Info

Title:
Effect of Oxycodone Hydrochloride Prolonged-release Tablets and Morphine Sulfate Prolonged-release Tablets on Patients with Severe Pain of Colorectal Cancer,Levels of Inflammatory Factors and Immune Indexes
文章编号:
1006-1959（2022）21-0134-03
作者:
刘明明; 黄仕豪
（宁都县人民医院肿瘤内科，江西 宁都 342800）
Author(s):
LIU Ming-ming; HUANG Shi-hao
(Department of Oncology,Ningdu County People’s Hospital,Ningdu 342800,Jiangxi,China)
关键词:
结直肠癌; 重度疼痛; 盐酸羟考酮; 硫酸吗啡
Keywords:
Colorectal cancer; Severe pain; Oxycodone hydrochloride; Morphine sulfate
分类号:
R730.5
DOI:
10.3969/j.issn.1006-1959.2022.21.035
文献标志码:
A
摘要:
目的 探讨盐酸羟考酮缓释片和硫酸吗啡缓释片对结直肠癌重度疼痛患者的效果。方法 选取2015年1月-2021年7月收治的结直肠癌重度疼痛患者69例，以随机数字表法分为MST组（n=34）和OXY组（n=35）。MST组给予硫酸吗啡缓释片治疗，OXY组给予盐酸羟考酮缓释片治疗，比较两组药物起效时间、药物止痛效果、不良反应发生情况、炎症因子水平[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、血清C反应蛋白（CRP）]、机体免疫功能（CD3+、CD4+、CD8+）、KPS评分改善情况。结果 OXY组药物起效时间短于MST组，药物止痛效果高于MST组，不良反应发生率低于MST组（P＜0.05）；两组治疗后IL-6、TNF-α、CRP水平低于治疗前，且OXY组低于MST组（P＜0.05）；两组治疗后CD3+、CD4+指标高于治疗前，CD8+指标低于治疗前，且OXY组CD3+、CD4+指标高于MST组，CD8+指标低于MST组（P＜0.05）；两组治疗后KPS评分高于治疗前，且OXY组KPS评分高于MST组（P＜0.05）。结论 盐酸羟考酮缓释片与硫酸吗啡缓释片在结直肠癌重度疼痛患者的临床治疗中皆能够起到镇痛效果，但盐酸羟考酮起效更快，镇痛止痛效果更好，药物不良反应更少，且能够有效调节炎症因子水平，提高机体免疫功能，改善患者健康状况，临床应用价值更高。
Abstract:
Objective To investigate the effect of oxycodone hydrochloride sustained-release tablets and morphine sulfate sustained-release tablets on patients with severe pain in colorectal cancer.Methods A total of 69 patients with severe pain of colorectal cancer admitted from January 2015 to July 2021 were randomly divided into MST group (n=34) and OXY group (n=35). The MST group was treated with morphine sulfate sustained-release tablets, and the OXY group was treated with oxycodone hydrochloride sustained-release tablets. The drug onset time, drug analgesic effect, adverse reactions, inflammatory factor levels [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), serum C-reactive protein (CRP)], immune function (CD3+, CD4+, CD8+), KPS score improvement were compared between the two groups.Results The onset time of OXY group was shorter than that of MST group, the analgesic effect was higher than that of MST group, and the incidence of adverse reactions was lower than that of MST group(P<0.05). After treatment, the levels of IL-6, TNF-α and CRP in the two groups were lower than those before treatment, and those in the OXY group were lower than the MST group (P<0.05). After treatment, the CD3+ and CD4+ indexes of the two groups were higher than those before treatment, and the CD8+ indexes were lower than those before treatment, and the CD3+ and CD4+ indexes of the OXY group were higher than those of the MST group, and the CD8+ indexes were lower than those of the MST group(P<0.05). The KPS score of the two groups after treatment was higher than that before treatment, and the KPS score of the OXY group was higher than that of the MST group(P<0.05).Conclusion Oxycodone hydrochloride sustained-release tablets and morphine sulfate sustained-release tablets can play an analgesic effect in the clinical treatment of patients with severe pain in colorectal cancer, but oxycodone hydrochloride takes effect faster, has better analgesic and analgesic effects, and has fewer adverse drug reactions. It can effectively regulate the level of inflammatory factors, improve the immune function of the body, improve the health status of patients, and has higher clinical application value.

参考文献/References:

[1]郝建礼,黄泽清.超声引导下腹横筋膜阻滞联合盐酸羟考酮注射液用于老年结肠癌根治术患者术后镇痛的临床观察[J].世界临床药物,2020,41(4):271-276.[2]齐宏亮,曲迎春,尹诗航.盐酸羟考酮缓释片在老年癌痛患者中的应用效果分析[J].癌症进展,2021,19(3):283-285. [3]王洋,苏英,毛文娟.加味芍药甘草汤联合硫酸吗啡缓释片治疗癌性疼痛气血两虚证临床研究[J].国际中医中药杂志,2020,42(4):329-333.[4]孙红梅,陈文彰,鲍云华.吗啡缓释片和即释片在中重度癌痛患者滴定中的临床效果[J].中华老年多器官疾病杂志,2020,19(8):599-604. [5]李丽,李海宁,贾红生.盐酸羟考酮缓释片直肠给药改善晚期肿瘤患者疼痛及生活质量的效果研究[J].实用癌症杂志,2018,33(7):1124-1126,1134.[6]罗娟,袁琦,刁长冬,等.盐酸羟考酮缓释片与芬太尼透皮贴剂治疗中重度癌症疼痛的不良反应比较分析[J].药物不良反应杂志,2021,23(7):361-364.[7]刘昭,李小江,张洪,等.化坚拔毒膜联合盐酸羟考酮缓释片治疗中重度癌性疼痛[J].国际中医中药杂志,2019,41(3):234-237.[8]杨婧,裴文仲,杨建东,等.羟考酮与曲马多对老年中度癌痛患者初始治疗效果的比较[J].癌症进展,2019,17(6):697-700,703.[9]曹东波,宋洋,黄雷.加味芍药甘草汤联合硫酸吗啡缓释片治疗气血两虚证癌性疼痛疗效及对患者疼痛介质、炎症因子的影响[J].中国实验方剂学杂志,2018,24(24):184-188.[10]喻超,隋成君,王秋石.盐酸羟考酮缓释片联合盐酸吗啡片用于门诊中重度癌痛患者药物初始剂量滴定的临床观察[J].中国医科大学学报,2020,49(1):71-75.[11]卜岗,孙欣,王辉,等.盐酸羟考酮缓释片联合氟哌噻吨美利曲辛片治疗晚期癌痛的疗效观察[J].现代肿瘤医学,2018,26(4):609-612. [12]张红霞,李炜,许学萍.盐酸羟考酮缓释片对老年晚期非小细胞肺癌患者镇痛效果及炎症因子水平的影响[J].海军医学杂志,2019,40(3):237-240.

相似文献/References:

[1]张西园.糖尿病与结直肠癌患者预后相关研究进展[J].医学信息,2018,31(01):55.[doi:10.3969/j.issn.1006-1959.2018.01.020]
　ZHANG Xi-yuan.Research Progress in the Relationship between Diabetes and the Prognosis of Colorectal Cancer[J].Journal of Medical Information,2018,31(21):55.[doi:10.3969/j.issn.1006-1959.2018.01.020]
[2]陈学敏,彭 琼.中性粒细胞与淋巴细胞比值联合癌胚抗原对结直肠癌早期诊断的研究[J].医学信息,2019,32(02):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
　CHEN Xue-min,PENG Qiong.Early Diagnosis of Colorectal Cancer by Neutrophil-lymphocyte Ratio Combined with Carcinoembryonic Antigen[J].Journal of Medical Information,2019,32(21):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
[3]李在明,魏正强.外泌体在结直肠癌中的研究进展[J].医学信息,2019,32(03):42.[doi:10.3969/j.issn.1006-1959.2019.03.014]
　LI Zai-ming,WEI Zheng-qiang.Research Progress of Exosomes in Colorectal Cancer[J].Journal of Medical Information,2019,32(21):42.[doi:10.3969/j.issn.1006-1959.2019.03.014]
[4]周玲玲,鞠乐乐,颜 玉.结直肠癌患者手术前后血清IGF-1水平变化及临床价值分析[J].医学信息,2019,32(04):121.[doi:10.3969/j.issn.1006-1959.2019.04.039]
　ZHOU Ling-ling,JU Le-le,YAN Yu.Analysis of Changes and Clinical Value of Serum IGF-1 Levels in Patients with Colorectal Cancer before and after Operation[J].Journal of Medical Information,2019,32(21):121.[doi:10.3969/j.issn.1006-1959.2019.04.039]
[5]陈小玉,白 鍊,贺春香.结直肠癌根治手术患者营养状况调查[J].医学信息,2019,32(05):83.[doi:10.3969/j.issn.1006-1959.2019.05.025]
　CHEN Xiao-yu,BAI Lian,HE Chun-xiang.Investigation on Nutritional Status of Patients Undergoing Radical Surgery for Colorectal Cancer[J].Journal of Medical Information,2019,32(21):83.[doi:10.3969/j.issn.1006-1959.2019.05.025]
[6]李大略,赵资文,刘兆礼,等.加速康复外科对合并有糖尿病的结直肠癌患者术后炎症反应与营养代谢的影响[J].医学信息,2019,32(07):67.[doi:10.3969/j.issn.1006-1959.2019.07.021]
　LI Da-lue,ZHAO Zi-wen,LIU Zhao-li,et al.Effect of Accelerated Rehabilitation Surgery on Postoperative Inflammatory Response and Nutrient Metabolism in Patients with Colorectal Cancer Complicated with Diabetes[J].Journal of Medical Information,2019,32(21):67.[doi:10.3969/j.issn.1006-1959.2019.07.021]
[7]王逸飞,王 志,左宏波,等.伊利替康联合替吉奥在晚期结直肠癌治疗的临床研究[J].医学信息,2019,32(07):158.[doi:10.3969/j.issn.1006-1959.2019.07.049]
　WANG Yi-fei,WANG Zhi,ZUO Hong-bo,et al.Clinical Study of Irinotecan Combined with Tegafur,Gimeracil and Oteracil Porassium Capsulesin the Treatment of Advanced Colorectal Cancer[J].Journal of Medical Information,2019,32(21):158.[doi:10.3969/j.issn.1006-1959.2019.07.049]
[8]谢 勇,涂经楷,肖明盛,等.腹腔镜与传统开腹结直肠癌根治术手术效果对比[J].医学信息,2019,32(11):98.[doi:10.3969/j.issn.1006-1959.2019.11.026]
　XIE Yong,TU Jing-kai,XIAO Ming-sheng,et al.Comparative of Laparoscopic and Traditional Open Radical Rectal Cancer Radical Operation[J].Journal of Medical Information,2019,32(21):98.[doi:10.3969/j.issn.1006-1959.2019.11.026]
[9]符青云,欧阳小明,郅 程,等.结直肠癌组织EGFR、BRAF及NRAS基因突变检测及临床意义分析[J].医学信息,2022,35(13):83.[doi:10.3969/j.issn.1006-1959.2022.13.018]
　FU Qing-yun,OUYANG Xiao-ming,ZHI Cheng,et al.Detection and Clinical Significance of EGFR, BRAF and NRAS Gene Mutations in Colorectal Cancer[J].Journal of Medical Information,2022,35(21):83.[doi:10.3969/j.issn.1006-1959.2022.13.018]
[10]李莎莎,李 芳,王卫峰,等.地中海饮食与结直肠癌的相关研究[J].医学信息,2019,32(15):6.[doi:10.3969/j.issn.1006-1959.2019.15.003]
　LI Sha-sha,LI Fang,WANG Wei-feng,et al.Correlation between Mediterranean Diet and Colorectal Cancer[J].Journal of Medical Information,2019,32(21):6.[doi:10.3969/j.issn.1006-1959.2019.15.003]

更新日期/Last Update: 1900-01-01