[1]卢景涛,彭 琼.非酒精性脂肪性肝病诊断联合BISAP评分对急性胰腺炎严重程度的预测价值[J].医学信息,2023,36(04):118-122.[doi:10.3969/j.issn.1006-1959.2023.04.023]
　LU Jing-tao,PENG Qiong.Predictive Value of NAFLD Diagnosis Combined with the BISAP Score for the Severity of Acute Pancreatitis[J].Journal of Medical Information,2023,36(04):118-122.[doi:10.3969/j.issn.1006-1959.2023.04.023]
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非酒精性脂肪性肝病诊断联合BISAP评分对急性胰腺炎严重程度的预测价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年04期
页码:
118-122
栏目:
论著
出版日期:
2023-02-15

文章信息/Info

Title:
Predictive Value of NAFLD Diagnosis Combined with the BISAP Score for the Severity of Acute Pancreatitis
文章编号:
1006-1959（2023）04-0118-05
作者:
卢景涛; 彭 琼
（安徽医科大学第三附属医院消化内科，安徽 合肥 230061）
Author(s):
LU Jing-tao; PENG Qiong
(Department of Gastroenterology,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,Anhui,China)
关键词:
非酒精性脂肪性肝病; 急性胰腺炎; BISAP评分
Keywords:
Non-alcoholic fatty liver disease; Acute pancreatitis; BISAP score
分类号:
R576
DOI:
10.3969/j.issn.1006-1959.2023.04.023
文献标志码:
A
摘要:
目的 分析急性胰腺炎（AP）病情严重程度与非酒精性脂肪性肝病（NAFLD）的相关性，研究NAFLD诊断联合BISAP评分预测AP严重程度的价值。方法 选取2020年10月-2022年6月于安徽医科大学第三附属医院住院的急性胰腺炎患者154例，根据是否患有非酒精性脂肪性肝病，分为NAFLD组与非NAFLD组，比较两组一般资料、实验室指标、住院时间、BISAP评分、中重症急性胰腺炎比例及并发症，使用多因素Logistic回归分析中重症急性胰腺炎的危险因素；计算BISAP评分、NAFLD诊断及两者联合预测中重症急性胰腺炎的效能。结果 两组年龄、BMI、高脂血症、C反应蛋白（CRP）、总胆红素、甘油三酯（TG）、住院时间、BISAP评分≥3的比例比较，差异有统计学意义（P＜0.05）；NAFLD组合并糖尿病、中重症急性胰腺炎、全身炎症反应综合征（SIRS）、肾衰竭、胰腺坏死及感染比例高于非NAFLD组，差异有统计学意义（P＜0.05）；多因素Logistic回归分析显示，合并NAFLD（OR=4.954，95%CI：1.323~18.550，P=0.018）、糖尿病（OR=4.283，95%CI：1.133~16.185，P=0.032）、高BMI（OR=1.287，95%CI：1.015~1.631，P=0.037）是中重症急性胰腺炎的危险因素；ROC曲线显示，BISAP评分、NAFLD诊断及两者联合预测中重症急性胰腺炎的曲线下面积（AUC）分别为0.805、0.682、0.888。结论 NAFLD、糖尿病、高BMI是中重症急性胰腺炎的独立危险因素，NAFLD诊断联合BISAP评分可提高预测急性胰腺炎严重程度的效能。
Abstract:
Objective To investigate the correlation between the severity of acute pancreatitis (AP) and non-alcoholic fatty liver disease (NAFLD), and to explore the value of diagnosis of NAFLD combined with BISAP score in predicting severity of AP.Methods A total of 154 patients with acute pancreatitis who were hospitalized in the Third Affiliated Hospital of Anhui Medical University from October 2020 to June 2022 were selected. According to whether they had nonalcoholic fatty liver disease, they were divided into NAFLD group and non-NAFLD group. The general data, laboratory indicators, hospitalization time, BISAP score, proportion of moderate to severe acute pancreatitis and complications were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of moderate to severe acute pancreatitis. The efficacy of BISAP score, NAFLD diagnosis and their combination in predicting severe acute pancreatitis was calculated.Results There were significant differences in age, BMI, hyperlipidemia, C-reactive protein (CRP), total bilirubin, triglyceride (TG), hospitalization time and BISAP score ≥3 scores between the two groups (P<0.05). The proportion of diabetes mellitus, moderate to severe acute pancreatitis, systemic inflammatory response syndrome (SIRS), renal failure, pancreatic necrosis and infection in NAFLD group was higher than that in non-NAFLD group (P<0.05). Multivariate logistic regression analysis showed that NAFLD (OR=4.954, 95%CI:1.323-18.550, P=0.018), diabetes (OR=4.283, 95%CI:1.133-16.185, P=0.032) and high BMI (OR=1.287, 95%CI:1.015-1.631, P=0.037) were risk factors for severe acute pancreatitis. The ROC curve showed that the area under the curve (AUC) of BISAP score, NAFLD diagnosis and combined prediction of severe acute pancreatitis were 0.805, 0.682 and 0.888, respectively.Conclusion NAFLD, diabetes and high BMI are independent risk factors for severe acute pancreatitis. NAFLD diagnosis combined with BISAP score can improve the efficacy of predicting the severity of acute pancreatitis.

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更新日期/Last Update: 1900-01-01