[1]黄 灿,杨侃侃,江 兵,等.基于生物信息学分析GLI1在胃癌中的表达及其临床意义[J].医学信息,2023,36(05):8-12,21.[doi:10.3969/j.issn.1006-1959.2023.05.002]
　HUANG Can,YANG Kan-kan,JIANG Bing,et al.Bioinformatics Analysis of GLI1 Expression in Gastric Cancer and its Clinical Significance[J].Journal of Medical Information,2023,36(05):8-12,21.[doi:10.3969/j.issn.1006-1959.2023.05.002]
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基于生物信息学分析GLI1在胃癌中的表达及其临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年05期
页码:
8-12,21
栏目:
生物信息学
出版日期:
2023-03-01

文章信息/Info

Title:
Bioinformatics Analysis of GLI1 Expression in Gastric Cancer and its Clinical Significance
文章编号:
1006-1959（2023）05-0008-06
作者:
黄 灿; 杨侃侃; 江 兵; 等
（安徽医科大学附属巢湖医院胃肠外科，安徽 合肥 238000）
Author(s):
HUANG Can; YANG Kan-kan; JIANG Bing; et al.
(Department of Gastrointestinal Surgery,Chaohu Hospital of Anhui Medical University,Hefei 238000,Anhui,China)
关键词:
胃癌; GLI1; 肿瘤免疫浸润; 数据挖掘
Keywords:
Gastric cancer; GLI1; Tumor immune infiltration; Data mining
分类号:
R735.2
DOI:
10.3969/j.issn.1006-1959.2023.05.002
文献标志码:
A
摘要:
目的 通过数据库进行数据挖掘的方法研究胶质瘤相关基因1（GLI1）在胃癌中的表达水平，分析GLI1预后在胃癌预后及肿瘤免疫浸润的相关性。方法 通过检索TIMER数据库和UALCAN数据库获得GLI1在泛癌中的表达。通过UALCAN数据库分析GLI1在胃癌组织和正常组织中的差异性表达，以及不同临床特征对GLI1的表达影响。检索GLI1在Kaplan-Meier Plotter 数据库的胃癌预后结果；检索Timer数据库获得GLI1与胃癌组织免疫浸润水平及肿瘤相关免疫细胞表面标志物的相关性。结果 GLI1在胃癌组织中的表达高于正常组织，GLI1高表达与胃癌预后不良呈正相关（OS：HR=2.56，95%CI：2.05~3.19，P＜1e-16；FP：HR=2.29，95%CI：1.82~2.87，P=3.1e-13；PPS：HR=3.02，95%CI：2.37~3.86，P＜1e-16）；GLI1表达促进胃癌免疫细胞（B细胞、CD4+T细胞、CD8+T细胞、中性粒细胞、巨噬细胞和树突状细胞）浸润（P＜0.01）；胃癌中GLI1表达水平与多数免疫细胞标志物正相关（P＜0.001）。结论 GLI1在胃癌患者中呈异常高表达，而高表达的GLI1在胃癌发生发展过程中可能起到促癌的作用，且可能是胃癌靶向治疗的一个潜在分子标志物。
Abstract:
Objective To study the expression level of glioma-associated gene 1 (GLI1) in gastric cancer by database data mining, and to analyze the correlation between GLI1 prognosis and tumor immune infiltration in gastric cancer.Methods The expression of GLI1 in pan-cancer was obtained by searching TIMER database and UALCAN database. The UALCAN database was used to analyze the differential expression of GLI1 in gastric cancer tissues and normal tissues, and the effect of different clinical features on the expression of GLI1. The prognostic results of GLI1 in gastric cancer in Kaplan-Meier Plotter database were retrieved. The correlation between GLI1 and immune infiltration level of gastric cancer tissues and tumor-associated immune cell surface markers was obtained by searching Timer database.Results The expression of GLI1 in gastric cancer tissues was higher than that in normal tissues. High expression of GLI1 was positively correlated with poor prognosis of gastric cancer (OS:HR=2.56,95%CI:2.05-3.19,P<1e-16; FP:HR=2.29,95%CI:1.82-2.87,P=3.1e-13; PPS:HR=3.02,95%CI:2.37-3.86,P<1e-16).The expression of GLI1 promoted the infiltration of gastric cancer immune cells (B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages and dendritic cells) (P<0.01). The expression level of GLI1 in gastric cancer was positively correlated with most immune cell markers (P<0.001).Conclusion GLI1 is abnormally highly expressed in patients with gastric cancer, and high expression of GLI1 may play a role in promoting the development of gastric cancer, and may be a potential molecular marker for targeted therapy of gastric cancer.

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更新日期/Last Update: 1900-01-01