[1]劳 拓.拉坦前列素与噻吗洛尔不同联用方案治疗原发性开角型青光眼的临床疗效和安全性观察[J].医学信息,2023,36(17):150-153.[doi:10.3969/j.issn.1006-1959.2023.17.031]
　LAO Tuo.Observation on Clinical Efficacy and Safety of Different Combination Regimens of Latanoprost and Timolol in the Treatment of Primary Open Angle Glaucoma[J].Journal of Medical Information,2023,36(17):150-153.[doi:10.3969/j.issn.1006-1959.2023.17.031]
点击复制

拉坦前列素与噻吗洛尔不同联用方案治疗原发性开角型青光眼的临床疗效和安全性观察()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年17期
页码:
150-153
栏目:
药物与临床
出版日期:
2023-09-01

文章信息/Info

Title:
Observation on Clinical Efficacy and Safety of Different Combination Regimens of Latanoprost and Timolol in the Treatment of Primary Open Angle Glaucoma
文章编号:
1006-1959（2023）17-0150-04
作者:
劳 拓
（百色市人民医院眼科，广西 百色 533000）
Author(s):
LAO Tuo
(Department of Ophthalmology,Baise People’s Hospital,Baise 533000,Guangxi,China)
关键词:
拉坦前列素; 噻吗洛尔; 原发性开角型青光眼
Keywords:
Latanoprost; Timolol; Primary open angle glaucoma
分类号:
R775.2
DOI:
10.3969/j.issn.1006-1959.2023.17.031
文献标志码:
A
摘要:
目的 观察拉坦前列素与噻吗洛尔不同联用方案治疗原发性开角型青光眼的临床有效性和安全性。方法 选取2019年5月-2022年5月在我院诊治的72例原发性开角型青光眼患者为研究对象，采用随机数字表法分为对照组和观察组，各36例。两组均给予拉坦前列素联合噻吗洛尔治疗，观察组噻吗洛尔每天给药1次，对照组噻吗洛尔每天给药2次，比较两组临床疗效、视力、24 h平均眼压、散光度、视野缺损评分、视网膜神经纤维层厚度及不良反应发生率。结果 观察组总有效率为94.44%，与对照组91.67%比较，差异无统计学意义（P＞0.05）；两组治疗后视力均高于治疗前，24 h平均眼压、散光度均低于治疗前，且两组间比较，差异无统计学意义（P＞0.05）；两组治疗后视野缺损评分均低于治疗前，视网膜神经纤维层厚度大于治疗前，且两组间比较，差异无统计学意义（P＞0.05）；观察组不良反应发生率为5.56%，低于对照组的16.67%（P＜0.05）。结论 拉坦前列素与噻吗洛尔联合治疗原发性开角型青光眼总有效率较高，且减少噻吗洛尔的给药次数不仅对临床疗效无影响，还可以降低不良反应发生率、改善视野受损和视网膜神经纤维层厚度，具有较理想的疗效和安全性。
Abstract:
Objective To observe the clinical efficacy and safety of different combination regimens of latanoprost and timolol in the treatment of primary open angle glaucoma.Methods A total of 72 patients with primary open angle glaucoma diagnosed and treated in our hospital from May 2019 to May 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 36 patients in each group. Both groups were treated with latanoprost combined with timolol, while the observation group was given timolol once a day, and the control group was given timolol twice a day. The clinical efficacy, visual acuity, 24 h average intraocular pressure, astigmatism, visual field defect score, retinal nerve fiber layer thickness and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.44%, which was compared with 91.67% of the control group, the difference was not statistically significant (P>0.05). The visual acuity of the two groups after treatment was higher than that before treatment, and the average intraocular pressure and astigmatism at 24 h were lower than those before treatment, and there was no significant difference between the two groups (P>0.05). After treatment, the visual field defect scores of the two groups were lower than those before treatment, and the retinal nerve fiber layer thickness was greater than that before treatment, and there was no significant difference between the two groups (P>0.05). The incidence of adverse reactions in the observation group was 5.56%, which was lower than 16.67% in the control group (P<0.05).Conclusion The total effective rate of latanoprost combined with timolol in the treatment of primary open-angle glaucoma is higher, and reducing the number of administration of timolol not only has no effect on the clinical efficacy, but also can reduce the incidence of adverse reactions, improve visual field damage and retinal nerve fiber layer thickness, with ideal efficacy and safety.

参考文献/References:

[1]王军,曾锦,尹东明.拉坦前列素联合马来酸噻吗洛尔与单用拉坦噻吗滴眼液治疗高眼内压的效果比较[J].广东医学,2017,37(5):751-753.[2]Adachi S,Yuki K,Awano-Tanabe S,et al.Factors associated with the occurrence of a fall in subjects with primary open-angle glaucoma[J].BMC Ophthalmol,2017,25:213.[3]中华医学会眼科学分会青光眼学组.我国原发性开角型青光眼眼颅压力梯度专家共识和建议(2017年)[J].中华眼科杂志,2017,53(2):89-91.[4]李俊.拉坦前列素、曲伏前列素和噻吗洛尔治疗原发性开角型青光眼的疗效比较分析[J].临床眼科杂志,2016,24(4):315-317.[5]董志章,甘一峰,张易南,等.他氟前列素治疗开角型青光眼的疗效观察[J].眼科新进展,2018,38(9):856-860.[6]王颖,牛辉,李军,等.曲伏前列素滴眼液联合复方丹参片对老年青光眼患者房水屏障功能及 MMP2 水平的影响[J].现代生物医学进展,2017,16(32):6326-6328,6352.[7]Li T,Lindsley K,Rouse B,et al.Comparative effectiveness of first-line medications for primary open-angle glaucoma: a systematic review and network meta-analysis[J].Ophthalmology,2018,123:129-140.[8]梁萍英,刘君,张丽红.溴莫尼定噻吗洛尔滴眼液治疗原发性 开角型青光眼疗效与安全性分析[J].中国药物与临床,2020,20(12):1936-1939. [9]Fingeret M,Gaddie IB,Bloomenstein M.Latano-prostene bunod ophthalmic solution 0.024％ :a new treatment op-tion for open angle glaucoma and ocular hypertension[J].Clin Exp Optom,2019,102(6):541-550.[10]刘金长.曲伏前列素滴眼液治疗原发性开角型青光眼的疗效与安全性观察[J].基层医学论坛,2018,22(10):1342-1343.[11]陈涛,吕伯昌,杨新光.曲伏前列素滴眼液治疗原发性开角型青光眼的疗效与安全性观察[J].陕西医学杂志,2017,44(2):238-239.[12]潘永明,殷悦.尼莫地平联合曲伏前列素滴眼液治疗原发性开角 型青光眼的疗效观察[J].现代药物与临床,2019,34(1):164-168.[13]Terelak-Borys B,Grabska-Liberek I,Piekarniak-Wozniak A,et al.Choroidal infarction in a glaucoma patient with Flammer syndrome: acase report with a long term follow-up[J].BMC Ophthalmol,2017,17(1):23.[14]仉雅洁,刘伟,魏会宇.布林佐胺与马来酸噻吗洛尔治疗原发性开角型青光眼效果比较[J].山东医药,2018,58(34):80-82.[15]陈媛媛,罗彩香.组合降压药治疗原发性开角型青光眼和高眼压 症的临床疗效[J].临床与病理杂志,2018,38(12):2637-2642.[16]韩宝雁,米强,贾冠美,等.拉坦前列素、噻吗洛尔和曲伏前列素治疗原发性开角型青光眼的疗效观察[J].河北医药,2020,42(5):1324-1326.[17]苗壮.不同种类前列腺素类滴眼液治疗原发性开角型青光眼的降眼压效果[J].中国伤残医学,2018,24(10):102-103.[18]叶炎生.浅针结合拉坦前列素治疗气郁化火证原发性开角型青光眼的临床观察[J].福建中医药大学,2020,6(1):119-121.[19]李威,王柳.不同种类前列腺素类滴眼液治疗原发性开角型青光眼的降眼压效果对比[J].中外医学研究,2018,16(5):64-66.[20]兰图.0.0015%他氟前列素滴眼液对原发性开角型青光眼患者眼压、眼血流动力学及血清细胞因子的影响[J].四川解剖学杂志,2018,9(7):103-106.

更新日期/Last Update: 1900-01-01