[1]王国芳.丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的临床疗效及对母婴结局的影响[J].医学信息,2023,36(18):144-147.[doi:10.3969/j.issn.1006-1959.2023.18.028]
　WANG Guo-fang.Clinical Effect of Ademetionine 1,4-Butanedisulfonate Combined with Polyene Phosphatidylcholine in the Treatment of Intrahepatic Cholestasis of Pregnancy and its Effect on Maternal and Infant Outcomes[J].Journal of Medical Information,2023,36(18):144-147.[doi:10.3969/j.issn.1006-1959.2023.18.028]
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丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的临床疗效及对母婴结局的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年18期
页码:
144-147
栏目:
药物与临床
出版日期:
2023-09-15

文章信息/Info

Title:
Clinical Effect of Ademetionine 1,4-Butanedisulfonate Combined with Polyene Phosphatidylcholine in the Treatment of Intrahepatic Cholestasis of Pregnancy and its Effect on Maternal and Infant Outcomes
文章编号:
1006-1959（2023）18-0144-04
作者:
王国芳
（玉山县中医院妇产科住院部，江西 玉山 334700）
Author(s):
WANG Guo-fang
(In-patient Department of Obstetrics and Gynecology Department,Yushan County Hospital of Traditional Chinese Medicine,Yushan 334700,Jiangxi,China)
关键词:
妊娠期肝内胆汁淤积症; 丁二磺酸腺苷蛋氨酸; 多烯磷脂酰胆碱; 肝功能
Keywords:
Intrahepatic cholestasis of pregnancy; Ademetionine 1; 4-butanedisulfonate; Polyene phosphatidylcholine; Liver function
分类号:
R714.255
DOI:
10.3969/j.issn.1006-1959.2023.18.028
文献标志码:
A
摘要:
目的 分析丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的临床疗效及对母婴结局的影响。方法 选取2020年1月-2022年12月我院治疗的65例妊娠期肝内胆汁淤积症患者为研究对象，采用随机数字表法分为观察组（n=33）和对照组（n=32）。对照组采用丁二磺酸腺苷蛋氨酸治疗，观察组在对照组基础上联合应用多烯磷脂酰胆碱治疗。比较两组临床疗效、瘙痒评分、肝功能指标[血清总胆汁酸（TBA）、丙氨酸氨基转移酶（ALT）、天冬氨酸转氨酶（AST）]、生活质量以及母婴结局。结果 观察组治疗总有效率为96.97%，高于对照组的75.00%（P＜0.05）；两组治疗后瘙痒评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后血清TBA、ALT、AST水平均低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后健康状态、精神状态和生理功能评分均高于治疗前，且观察组高于对照组（P＜0.05）；观察组不良妊娠结局发生率低于对照组（P＜0.05）。结论 丁二磺酸腺苷蛋氨酸联合多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症可提高临床疗效，改善母婴结局，减轻临床瘙痒症状，促进肝功能指标恢复，提升患者生活质量水平，值得临床应用。
Abstract:
Objective To evaluate the clinical efficacy of ademetionine 1,4-butanedisulfonate combined with polyene phosphatidylcholine in the treatment of intrahepatic cholestasis of pregnancy and its effect on maternal and infant outcomes.Methods A total of 65 patients with intrahepatic cholestasis of pregnancy treated in our hospital from January 2020 to December 2022 were selected as the research objects, and they were divided into observation group (n=33) and control group (n=32) by random number table method. The control group was treated with ademetionine 1,4-butanedisulfonate, and the observation group was treated with polyene phosphatidylcholine on the basis of the control group. The clinical efficacy, pruritus score, liver function indexes [serum total bile acid (TBA), alanine aminotransferase (ALT), aspartate aminotransferase (AST)], quality of life and maternal and infant outcomes were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.97%, which was higher than 75.00% in the control group (P<0.05). The pruritus score of the two groups after treatment was lower than that before treatment, and that in the observation group was lower than that in the control group (P<0.05). After treatment, the levels of serum TBA, ALT and AST in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). After treatment, the scores of health status, mental status and physiological function in the two groups were higher than those before treatment, and those in the observation group were higher than the control group (P<0.05). The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group (P<0.05).Conclusion For intrahepatic cholestasis of pregnancy, ademetionine 1,4-butanedisulfonate combined with polyene phosphatidylcholine can improve clinical efficacy, improve maternal and infant outcomes, reduce clinical itching symptoms, promote the recovery of liver function indicators, and improve the quality of life of patients, which is worthy of clinical application.

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更新日期/Last Update: 1900-01-01