[1]杨锦龙,刘 欢,吕秋菊,等.非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究[J].医学信息,2018,31(10):93-95,98.[doi:10.3969/j.issn.1006-1959.2018.10.028]
　YANG Jin-long,LIU Huan,LV Qiu-ju,et al.Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients[J].Journal of Medical Information,2018,31(10):93-95,98.[doi:10.3969/j.issn.1006-1959.2018.10.028]
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非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年10期
页码:
93-95,98
栏目:
临床研究
出版日期:
2018-05-15

文章信息/Info

Title:
Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients
文章编号:
1006-1959（2018）10-0093-04
作者:
杨锦龙1; 刘 欢2; 吕秋菊2; 张 晋2
乐山市人民医院心血管内科1，内分泌科2，四川 乐山 614000
Author(s):
YANG Jin-long1; LIU Huan2; LV Qiu-ju2; ZHANG Jin2
Department of Cardiology1,Department of Endocrinology2,Leshan City People's Hospital,Leshan 614000,Sichuan,China
关键词:
冠心病; 糖化血红蛋白; 胰岛素抵抗; SYNTAX积分
Keywords:
Key words：Coronary heart disease; Glycosylated hemoglobin; Insulin resistance; SYNTAX scores
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2018.10.028
文献标志码:
A
摘要:
目的 研究非糖尿病的冠心病患者中糖化血红蛋白（HbA1c）和胰岛素抵抗与冠状动脉病变严重程度的关系。方法 纳入临床疑诊冠心病并接受冠状动脉造影的非糖尿病患者184例，依据SYNTAX积分分为轻度狭窄组（0~22分）60例、中度狭窄组（23~32分）76例、重度狭窄组（≥33分）48例，采用Pearson相关性分析及多元线性逐步回归分析SYNTAX积分与HbA1c水平、稳态模型胰岛素抵抗指数（HOMA-IR）的关系。结果 三组间年龄、吸烟史、TC、LDL-C、HbA1c、HOMA-IR及CRP水平差异有统计学意义（P＜0.05）。相关性分析显示SYNTAX积分与HbA1c、HOMA-IR及CRP水平呈正相关，HbA1c与HOMA-IR呈正相关，多元线性逐步回归分析显示年龄、吸烟、HbA1c、HOMA-IR及CRP与冠脉病变程度独立相关。结论 在非糖尿病的冠心病人群中存在胰岛素抵抗，且胰岛素抵抗、HbA1c水平与冠状动脉病变严重程度密切相关。
Abstract:
Abstract：Objective To study the relationship between glycosylated hemoglobin(HbA1c)and insulin resistance and severity of coronary artery disease in non-diabetic patients with coronary heart disease.Methods Among 184 non-diabetic patients with suspected coronary heart disease who underwent coronary angiography,according to SYNTAX scores,60 patients with mild stenosis(0 to 22 points),76 patients with moderate stenosis(23 to 32 points),In 48 patients with severe stenosis group(≥33 points),Pearson correlation analysis and multiple linear stepwise regression were used to analyze the relationship between SYNTAX scores and HbA1c level and homeostasis model insulin resistance index(HOMA-IR).Results There was significant difference in age,smoking history,TC, LDL-C,HbA1c,HOMA-IR and CRP levels among the three groups(P<0.05).Correlation analysis showed that SYNTAX scores was positively correlated with HbA1c,HOMA-IR,and CRP levels,and HbA1c was positively correlated with HOMA-IR.Multiple linear stepwise regression analysis showed that age, smoking,HbA1c,HOMA-IR,and CRP were independently associated with the degree of coronary artery disease.Conclusion Insulin resistance exists in non-diabetic patients with coronary heart disease,and insulin resistance and HbA1c levels are closely related to the severity of coronary artery disease.

参考文献/References:

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更新日期/Last Update: 2018-05-15