[1]闫宇梅.血清胱抑素C及同型半胱氨酸与2型糖尿病 视网膜病变的相关性分析[J].医学信息,2018,31(17):89-91.[doi:10.3969/j.issn.1006-1959.2018.17.027]
　YAN Yu-mei.Correlation between Serum Cystatin C and Homocysteine and Type 2 Diabetic Retinopathy[J].Journal of Medical Information,2018,31(17):89-91.[doi:10.3969/j.issn.1006-1959.2018.17.027]
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血清胱抑素C及同型半胱氨酸与2型糖尿病 视网膜病变的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年17期
页码:
89-91
栏目:
临床研究
出版日期:
2018-09-01

文章信息/Info

Title:
Correlation between Serum Cystatin C and Homocysteine and Type 2 Diabetic Retinopathy
文章编号:
1006-1959（2018）17-0089-03
作者:
闫宇梅
晋煤集团总医院内分泌科，山西 晋城 048006
Author(s):
YAN Yu-mei
Department of Endocrinology,General Hospital of Jinmei Group,Jincheng 048006,Shanxi,China
关键词:
糖尿病视网膜病变; 血清胱抑素C; 同型半胱氨酸; 相关性
Keywords:
Key words：Diabetic retinopathy; Serum cystatin C; Homocysteine; Correlation
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2018.17.027
文献标志码:
A
摘要:
目的 探讨CysC与Hcy与2型糖尿病视网膜病变的相关性。方法 选取我院2017年1月~12月收治的2型糖尿病患者160例，根据眼底照相结果分为糖尿病视网膜病变组（DR组）和糖尿病无视网膜病变组（NDR组），每组80例，同时选取健康受试者80例作为对照组。观察各组患者血糖、血脂、血清CysC及Hcy水平。结果 ①DR组和NDR组SBP、DBP、FBG、2hBG、TG、TC、LDL-C、BUN、SCr、HbA1C、CysC和Hcy水平均高于对照组，差异具有统计学意义（P＜0.05）；DR组和NDR组HDL-C水平低于对照组，差异具有统计学意义（P＜0.05）；DR组SBP、TG、SCr、CysC和Hcy水平高于NDR组，差异具有统计学意义（P＜0.05）。②CysC与病程、TG、SCr、Hcy呈正相关（r=0.428、0.490、0.479、0.215，P＜0.05），与BMI、SBP、LDL-C、FBG无明显相关性。③Logistic多元回归分析显示：TG、SBP、CysC和Hcy为影响2型糖尿病视网膜病变发生的危险因素。结论 高CysC及Hcy水平是发生糖尿病视网膜病变的危险因素，CysC联合Hcy检测对2型糖尿病视网病变的诊治有一定指导意义。
Abstract:
Abstract：Objective To investigate the relationship between CysC and Hcy and type 2 diabetic retinopathy.Methods A total of 160 patients with type 2 diabetes admitted to our hospital from January to December 2017 were enrolled.According to the results of fundus photography,the patients were divided into diabetic retinopathy group(DR group)and diabetic non-retinopathy group(NDR group),80 cases in each group,and 80 healthy subjects were selected as the control group.Blood glucose,blood lipids,serum CysC and Hcy levels were observed in each group.Results ①The levels of SBP,DBP,FBG,2hBG,TG,TC,LDL-C,BUN,SCr,HbA1C,CysC and Hcy in DR group and NDR group were higher than those in the control group,the difference was statistically significant(P<0.05);The HDL-C levels in the DR group and the NDR group were lower than those in the control group,the difference was statistically significant(P<0.05);the levels of SBP,TG,SCr,CysC and Hcy in the DR group were higher than those in the NDR group,the difference was statistically significant(P<0.05).②CysC was positively correlated with disease course,TG,SCr and Hcy(r=0.428,0.490,0.479,0.215,P<0.05),and had no significant correlation with BMI,SBP,LDL-C and FBG.③Logistic multiple regression analysis showed that TG,SBP,CysC and Hcy were risk factors for the development of type 2 diabetic retinopathy.Conclusion High CysC and Hcy levels are risk factors for diabetic retinopathy.CysC combined with Hcy detection has certain guiding significance for the diagnosis and treatment of type 2 diabetic retinopathy.

参考文献/References:

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更新日期/Last Update: 2018-09-01