[1]杨森果,毛大华,杨海松,等.E-cadherin与肿瘤侵袭、转移相关性研究进展[J].医学信息,2018,31(03):3-6.[doi:10.3969/j.issn.1006-1959.2018.04.002]
　YANG Sen-guo,MAO Da-hua,YANG Hai-song,et al.Research Progress of the Correlation between E-cadherin and Tumor Invasion and Metastasis[J].Medical Information,2018,31(03):3-6.[doi:10.3969/j.issn.1006-1959.2018.04.002]
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E-cadherin与肿瘤侵袭、转移相关性研究进展()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年03期
页码:
3-6
栏目:
出版日期:
2018-02-01

文章信息/Info

Title:
Research Progress of the Correlation between E-cadherin and Tumor Invasion and Metastasis
文章编号:
1006-1959（2018）03-0003-03
作者:
杨森果; 毛大华; 杨海松; 陈腾祥; 张萌萌
贵州医科大学，贵州 贵阳 550000
Author(s):
YANG Sen-guo; MAO Da-hua; YANG Hai-song; CHEN Teng-xiang; ZHANG Meng-meng
Department of Breast Surgery,Affiliated Hospital of Guizhou Medical University,Guiyang 550000,Guizhou,China
关键词:
E-cadherin; 上皮-间质转化; 肿瘤; 侵袭; 转移
Keywords:
E-cadherin; Epithelial-mesenchymaltransition; Tumor; Invasion; Metastasis
分类号:
R73-37
DOI:
10.3969/j.issn.1006-1959.2018.04.002
文献标志码:
A
摘要:
恶性肿瘤的侵袭、转移特性使其成为癌症患者死亡的首要原因，不仅给治疗带来了一定的难度，更让患者承受了身体及心理的巨大痛苦。探究恶性肿瘤侵袭、转移的机制，并针对其相关分子标志物寻找抑制靶点，是临床医务工作者及基础医学研究者面临的巨大挑战。恶性肿瘤的侵袭、转移机制是一个多方面因素相互作用的复杂过程，包括了肿瘤细胞自身生物学行为、肿瘤细胞生存的微环境、及各种细胞因子、信号通路等因素。上皮-间质转化是近年来肿瘤侵袭、转移领域的研究热点，而上皮型钙黏蛋白是上皮-间质转化过程中一种主要的蛋白标志物，更好的理解上皮型钙黏蛋白与上皮-间质转化的关系及它们在癌症进展中所涉及的机制，能够为晚期转移性肿瘤治疗及预防的相关研究提供理论及实验依据。因此本文就上皮-间质转化与肿瘤侵袭、转移的研究作一综述。
Abstract:
The invasion and metastasis of malignant tumor make it the leading cause of death in cancer patients.It not only brings some difficulties to the treatment,but also endures great physical and psychological suffering.To explore the mechanism of invasion and metastasis of malignant tumor and find the target of inhibition against its related molecular markers is a great challenge for clinical medical workers and basic medical researchers.Malignant tumor invasion and metastasis mechanism is a complex process of interaction of many factors,including the biological behavior of tumor cells themselves,the microenvironment of tumor cells survival, and various cytokines,signaling pathways and other factors.Epithelial-mesenchymal transition(EMT)is a hotspot in the field of tumor invasion and metastasis in recent years.E-cadherin is a major protein marker in EMT,and better Understanding the relationship between E-cadherin and EMT and their mechanisms involved in cancer progression can provide theoretical and experimental evidence for the research on the treatment and prevention of advanced metastatic tumors.Therefore,this article reviews E-cadherin and tumor invasion and metastasis.

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更新日期/Last Update: 2018-02-01