[1]张恺悦,陈幼琼.乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究[J].医学信息,2019,32(04):138-139.[doi:10.3969/j.issn.1006-1959.2019.04.044]
　ZHANG Kai-yue,CHEN You-qiong.Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn[J].Journal of Medical Information,2019,32(04):138-139.[doi:10.3969/j.issn.1006-1959.2019.04.044]
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乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年04期
页码:
138-139
栏目:
药物与临床
出版日期:
2019-02-15

文章信息/Info

Title:
Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn
文章编号:
1006-1959（2019）04-0138-02
作者:
张恺悦; 陈幼琼
（贵州省人民医院烧伤整形外科，贵州 贵阳 550002）
Author(s):
ZHANG Kai-yue; CHEN You-qiong
(Department of Burn and Plastic Surgery,Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou,China)
关键词:
乌司他丁; 血必净; 脓毒症; 凝血功能
Keywords:
Ulinastatin; Xuebijing; Sepsis; Coagulation
分类号:
R459.7
DOI:
10.3969/j.issn.1006-1959.2019.04.044
文献标志码:
A
摘要:
目的 研究乌司他丁、血必净联合治疗对烧伤后脓毒症凝血功能及全身炎性反应影响。方法 回顾分析2016年6月~2018年6月在我院诊治的146例烧伤后脓毒症患者临床资料，随机分为对照组和观察组，各73例。对照组采用常规综合治疗，观察组在对照组基础上采用乌司他丁联合血必净治疗，观察两组治疗患者治疗前后凝血功能及全身炎性反应情况。结果 治疗后，观察组凝血酶原时间（PT）、纤维蛋白原（FIB）、血纤维蛋白原降解产物（FDP）、部分凝血活酶时间（APTT）、凝血酶时间（TT）均优于对照组，差异均有统计学意义（P＜0.05）；观察组TNF-α、IL-6、IL-10、CRP水平改善优于对照组，差异有统计学意义（P＜0.05）。结论 乌司他丁、血必净联合治疗对烧伤后脓毒症可以改善凝血功能，减轻炎性反应，促进患者的康复。
Abstract:
Objective To study the effects of combination therapy with ulinastatin and Xuebijing on coagulation function and systemic inflammatory response in post-burn sepsis. Methods The clinical data of 146 patients with post-burn sepsis diagnosed in our hospital from June 2016 to June 2018 were retrospectively analyzed and randomly divided into control group and observation group, 73 cases each. The control group was treated with conventional comprehensive treatment. The observation group was treated with ulinastatin combined with Xuebijing on the basis of the control group. The coagulation function and systemic inflammatory response of the two groups were observed before and after treatment. Results After treatment, prothrombin time (PT), fibrinogen (FIB), fibrinogen degradation product (FDP), partial thromboplastin time (APTT), and thrombin time (TT) were observed in the observation group superior to the control group, the difference was statistically significant (P<0.05); observation group TNF-α, The levels of IL-6, IL-10 and CRP were better than those of the control group,the difference was statistically significant (P<0.05). Conclusion Combined treatment with ulinastatin and Xuebijing can improve blood coagulation, reduce inflammatory reaction and promote rehabilitation of patients with post-burn sepsis.

参考文献/References:


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更新日期/Last Update: 2019-03-07