[1]周 琳,方界界.不同白蛋白水平的肾病综合征患者凝血功能比较[J].医学信息,2020,33(20):94-95，98.[doi:10.3969/j.issn.1006-1959.2020.20.027]
　ZHOU Lin,FANG Jie-jie.Comparison of Coagulation Function in Nephrotic Syndrome Patients with Different Albumin Levels[J].Medical Information,2020,33(20):94-95，98.[doi:10.3969/j.issn.1006-1959.2020.20.027]
点击复制

不同白蛋白水平的肾病综合征患者凝血功能比较()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年20期
页码:
94-95，98
栏目:
临床研究
出版日期:
2020-10-15

文章信息/Info

Title:
Comparison of Coagulation Function in Nephrotic Syndrome Patients with Different Albumin Levels
文章编号:
1006-1959（2020）20-0094-03
作者:
周 琳; 方界界
（浙江大学医学院附属邵逸夫医院检验科，浙江 杭州 310016）
Author(s):
ZHOU Lin; FANG Jie-jie
(Department of Laboratory Medicine,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University, Hangzhou310016,Zhejiang,China)
关键词:
肾病综合征; D-二聚体; 纤维蛋白原; 白蛋白
Keywords:
Nephrotic syndrome; D-dimer; Fibrinogen; Albumin
分类号:
R692.6
DOI:
10.3969/j.issn.1006-1959.2020.20.027
文献标志码:
A
摘要:
目的 探究不同白蛋白水平对肾病综合征（NS）患者凝血功能的影响。方法 选取浙江大学医学院附属邵逸夫医院2018年1月~2019年7月临床确诊为肾病综合征的86例患者作为A组，另选取同期我院体检中心健康者30名作为B组，根据白蛋白水平将A组分为C组（白蛋白＜20 g/L）38例和D组（白蛋白≥20 g/L）48例。比较A组与B组、C组与D组凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）、纤维蛋白原（Fg）、凝血酶时间（TT）及D-二聚体（D-D），分析Fg、D-D与ALB的相关性。结果 A组与B组PT比较，差异无统计学意义（P＞0.05）；A组APTT、Fg、TT和D-D均高于B组，差异有统计学意义（P＜0.05）；C组与D组PT、APTT及D-D比较，差异无统计学意义（P＞0.05）；C组TT和Fg均高于D组，差异有统计学意义（P＜0.05）；Fg、D-D与ALB均呈负相关（r=-0.410、-0.263）。结论 肾病综合征患者凝血功能受不同水平白蛋白影响，当白蛋白水平低于20g/L时，患者更容易形成高凝状态。通过监测凝血功能指标和白蛋白浓度能够指导预防性抗凝，降低血栓发生率，改善患者预后。
Abstract:
Objective To explore the effects of different albumin levels on coagulation function in patients with nephrotic syndrome (NS).Methods 86 patients who were clinically diagnosed with nephrotic syndrome in the Sir Run Run Shaw Hospital of Zhejiang University School of Medicine from January 2018 to July 2019 were selected as group A, and 30 healthy people from the physical examination center of our hospital during the same period were selected as group B.According to albumin level, group A was divided into group C (albumin <20 g/L) 38 cases and group D (albumin ≥20 g/L) 48 cases.Compare the prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (Fg), thrombin time (TT) and D-dimer(D-D) between group A and group B, group C and group D.Analyze the correlation between Fg, D-D and ALB.Results There was no significant difference in PT between group A and group B (P>0.05); APTT, Fg, TT and D-D in group A were higher than those in group B,the difference was statistically significant (P<0.05); group C and D compared with group PT, APTT and D-D, the difference was not statistically significant (P>0.05); TT and Fg of group C were higher than group D, the difference was statistically significant (P<0.05); Fg, D-D and ALB were all negatively correlated (r=-0.410, -0.263).Conclusion The coagulation function of patients with nephrotic syndrome was affected by different levels of albumin.When the albumin level was lower than 20g/L, patients were more likely to develop a hypercoagulable state. Monitoring the coagulation function indexes and albumin concentration could guide preventive anticoagulation, reduce the incidence of thrombosis, and improve the prognosis of patients.

参考文献/References:

[1]高志华,贾彦诺,刘丽,等.肾病综合征并发血栓的危险因素、病理机制及预防[J].中国老年学杂志,2015(12):3460-3462. [2]胡燕,王圣治.中西医结合治疗及预防肾病综合征下肢静脉血栓及高凝的研究进展[J].检验医学与临床,2019,16(21):3223-3224,3232. [3]屈桂琼.简述对肾病综合征患儿血液高凝状态的诊断与治疗[J].当代医药论丛,2017,15(19):22-23. [4]徐晓红.肾病综合征患者检测凝血指标的临床意义[J].中国卫生检验杂志,2016,26(12):1739-1740. [5]岳冲,贾强.血浆白蛋白水平不同的原发性肾病综合征患者凝血功能对比[J].世界临床药物,2018,39(11):760-763. [6]王宏天.纤维蛋白原与肾脏疾病[J].肾脏病与透析肾移植杂志,2016,25(5):466-469. [7]黄劲,尹小建,黄芳.纤维蛋白原相关药物研究进展[J].药学研究,2019,38(3):167-171. [8]雷敏,江德鹏.D-二聚体检测在静脉血栓栓塞症诊断中的应用新进展[J].基层医学论坛,2018,22(7):985-987. [9]Jacobs B,Obi A,Wakefield T.Diagnostic biomarkers in venous thromboembolic disease[J].Journal of Vascular Surgery Venous&Lymphatic Disorders,2016:S2213333X16300130.

相似文献/References:

[1]和珍珍,吴彦洪,刘艳,等.凝血指标测定对诊断胎盘早剥的价值分析[J].医学信息,2018,31(01):153.[doi:10.3969/j.issn.1006-1959.2018.01.060]
　HE Zhen-zhen,WU Yan-hong,LIU Yan,et al.Value Analysis of Coagulation Index in Diagnosing Placental Abruption[J].Medical Information,2018,31(20):153.[doi:10.3969/j.issn.1006-1959.2018.01.060]
[2]孙朝霞,曹显刚,赵 利,等.发热伴血小板减少综合征患者D-二聚体、心肌酶谱及肝酶谱的检测[J].医学信息,2018,31(03):85.[doi:10.3969/j.issn.1006-1959.2018.03.026]
　SUN Zhao-xia,CAO Xian-gang,ZHAO li,et al.Detection of D-Dimer,Myocardial and Liver Enzymes in Patients with Fever and Thrombocytopenia Syndrome[J].Medical Information,2018,31(20):85.[doi:10.3969/j.issn.1006-1959.2018.03.026]
[3]刘广涛,关凤军,董 晨.原发性肾病综合征患儿肾组织P-gp170蛋白和mRNA表达与临床病理及预后的关系[J].医学信息,2018,31(21):61.[doi:10.3969/j.issn.1006-1959.2018.21.017]
　LIU Guang-tao,GUAN Feng-jun,DONG Chen.Relationship between the Expression of p-gp170 Protein and mRNA in Renal Tissue of Children with Primary Nephrotic Syndrome and Clinical Pathology and Prognosis[J].Medical Information,2018,31(20):61.[doi:10.3969/j.issn.1006-1959.2018.21.017]
[4]钱朝庆,刘 淼,王家平,等.肾病综合征合并肾静脉血栓应用阿加曲班疗效评价[J].医学信息,2018,31(21):135.[doi:10.3969/j.issn.1006-1959.2018.21.038]
　QIAN Chao-qing,LIU Miao,WANG Jia-ping,et al.Clinical Efficacy Evaluation of Argatroban in Nephrotic Syndrome with Renal Vein Thrombosis[J].Medical Information,2018,31(20):135.[doi:10.3969/j.issn.1006-1959.2018.21.038]
[5]付云杰.肺癌患者血浆D-二聚体、NSE及CYFRA21-1联合检测的临床价值[J].医学信息,2018,31(23):161.[doi:10.3969/j.issn.1006-1959.2018.23.047]
　FU Yun-jie.Clinical Value of the Plasma D-dimer and Serum NSE,CYFRA21-1 Combined Detection in the Diagnosis of Lung Cancer[J].Medical Information,2018,31(20):161.[doi:10.3969/j.issn.1006-1959.2018.23.047]
[6]赵华莹,李运泽,韦天灵,等.肝硬化合并门静脉血栓形成的危险因素分析[J].医学信息,2019,32(03):86.[doi:10.3969/j.issn.1006-1959.2019.03.026]
　ZHAO Hua-ying,LI Yun-ze,WEI Tian-ling,et al.Analysis of Risk Factors for Cirrhotic Patients with Portal Vein Thrombosis[J].Medical Information,2019,32(20):86.[doi:10.3969/j.issn.1006-1959.2019.03.026]
[7]宫园园.LDL、Hcy、D-二聚体及颈动脉粥样硬化与急性缺血性脑卒中相关性研究[J].医学信息,2019,32(05):117.[doi:10.3969/j.issn.1006-1959.2019.05.036]
　GONG Yuan-yuan.Correlation between LDL,Hcy,D-dimer and Carotid Atherosclerosis and Acute Ischemic Stroke[J].Medical Information,2019,32(20):117.[doi:10.3969/j.issn.1006-1959.2019.05.036]
[8]祁 闻,赵 红,王龙胜,等.肺栓塞CTPA间接征象诊断价值分析及临床意义[J].医学信息,2019,32(08):88.[doi:10.3969/j.issn.1006-1959.2019.08.026]
　QI Wen,ZHAO Hong,WANG Long-sheng,et al.Diagnostic Value and Clinical Significance of CTPA indirect signs in Pulmonary Embolism[J].Medical Information,2019,32(20):88.[doi:10.3969/j.issn.1006-1959.2019.08.026]
[9]杜治国,何 龙,黄 进,等.下肢创伤骨折后静脉血栓栓塞症相关检测项目分析[J].医学信息,2019,32(10):64.[doi:10.3969/j.issn.1006-1959.2019.10.022]
　DU Zhi-guo,HE Long,HUANG Jin,et al.Analysis of Related Items of Venous Thromboembolism after Traumatic Fracture of Lower Extremity[J].Medical Information,2019,32(20):64.[doi:10.3969/j.issn.1006-1959.2019.10.022]
[10]李大千,蒋 云,梅燕萍.抗凝血酶Ⅲ、D-二聚体与纤维蛋白原在 下肢静脉血栓形成中的临床应用[J].医学信息,2019,32(17):167.[doi:10.3969/j.issn.1006-1959.2019.17.057]
　LI Da-qian,JIANG Yun,MEI Yan-ping.Clinical Application of Antithrombin III,D-dimer and Fibrinogen in Venous Thrombosis of Lower Extremity[J].Medical Information,2019,32(20):167.[doi:10.3969/j.issn.1006-1959.2019.17.057]

更新日期/Last Update: 1900-01-01