[1]张 明.miRNA及lncRNA在糖尿病肾病中的作用机制及临床诊断应用[J].医学信息,2020,33(21):58-61.[doi:10.3969/j.issn.1006-1959.2020.21.017]
 ZHANG Ming.The Mechanism of miRNA and lncRNA in Diabetic Nephropathy and Clinical Diagnosis Application[J].Medical Information,2020,33(21):58-61.[doi:10.3969/j.issn.1006-1959.2020.21.017]
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miRNA及lncRNA在糖尿病肾病中的作用机制及临床诊断应用()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年21期
页码:
58-61
栏目:
综述
出版日期:
2020-11-01

文章信息/Info

Title:
The Mechanism of miRNA and lncRNA in Diabetic Nephropathy and Clinical Diagnosis Application
文章编号:
1006-1959(2020)21-0058-04
作者:
张 明
(天津市宁河区医院检验科,天津 301500)
Author(s):
ZHANG Ming
(Department of Laboratory Medicine,Tianjin Ninghe District Hospital,Tianjin 301500,China)
关键词:
糖尿病肾病生物标志物临床诊断微小RNA长链非编码RNA
Keywords:
Diabetic nephropathyBiomarkerClinical diagnosismicroRNALong non-coding RNA
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2020.21.017
文献标志码:
A
摘要:
糖尿病肾病(DN)是最主要的一种糖尿病微血管并发症,也是目前首位引起终末期肾病(ESRD)的原因。因此其早期诊断对于减少DN的发生、延缓疾病进展和改善患者生活质量至关重要。DN目前的诊断主要依靠尿微量白蛋白检测,但其检测结果会受到多种因素的影响,具有较大的局限性。近年来有学者发现微小RNA(miRNA)和长链非编码RNA(lncRNA)与DN和ESRD密切相关,可能有助于DN的早期诊断和疾病进展的预测。本文主要就miRNA及lncRNA在糖尿病肾病中的作用机制及临床诊断中应用进展作一综述,以期为DN的早期诊断提供新的思路。
Abstract:
Diabetic nephropathy (DN) is the most important type of diabetic microvascular complication and is currently the first cause of end-stage renal disease (ESRD). Therefore, its early diagnosis is essential to reduce the occurrence of DN, delay disease progression and improve the quality of life of patients. The current diagnosis of DN mainly relies on urine microalbumin detection, but its detection results will be affected by a variety of factors, which have greater limitations. In recent years, some scholars have discovered that microRNA (miRNA) and long-chain non-coding RNA (lncRNA) are closely related to DN and ESRD, which may contribute to the early diagnosis of DN and the prediction of disease progression. This article mainly reviews the mechanism of miRNA and lncRNA in diabetic nephropathy and the progress in clinical diagnosis, in order to provide new ideas for the early diagnosis of DN.

参考文献/References:

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更新日期/Last Update: 1900-01-01