[1]王红艳,潘 利.自拟抑癌汤联合阿帕替尼治疗对中晚期胃癌患者的疗效及对血清CEA、CA199的影响[J].医学信息,2021,34(14):166-168.[doi:10.3969/j.issn.1006-1959.2021.14.047]
　WANG Hong-yan,PAN Li.Efficacy of Self-made Anti Cancer Soup Combined with Apatinib on Patients with Middle and Advanced Gastric Cancer and Its Effect on Serum CEA,CA199[J].Medical Information,2021,34(14):166-168.[doi:10.3969/j.issn.1006-1959.2021.14.047]
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自拟抑癌汤联合阿帕替尼治疗对中晚期胃癌患者的疗效及对血清CEA、CA199的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
166-168
栏目:
中医中药
出版日期:
2021-07-15

文章信息/Info

Title:
Efficacy of Self-made Anti Cancer Soup Combined with Apatinib on Patients with Middle and Advanced Gastric Cancer and Its Effect on Serum CEA,CA199
文章编号:
1006-1959（2021）14-0166-03
作者:
王红艳; 潘 利
（北大医疗海洋石油医院中医科1，外科2，天津 300452）
Author(s):
WANG Hong-yan; PAN Li
(Department of Traditional Chinese Medicine1,Department of Surgery2,Peking University Medical Offshore Oil Hospital, Tianjin 300452,China)
关键词:
胃癌; 阿帕替尼; 自拟抑癌汤; 毒副反应
Keywords:
Gastric cancer; Apatinib; Self-made anticancer soup; Side effects
分类号:
R735.2
DOI:
10.3969/j.issn.1006-1959.2021.14.047
文献标志码:
A
摘要:
目的 探讨自拟抑癌汤联合阿帕替尼治疗对中晚期胃癌患者的疗效及对血清CEA、CA199的影响。方法 选取2016年7月~2018年8月我院接受治疗的中晚期胃癌患者46例，根据治疗方式不同分为西药组和联合组，每组23例。西药组给予阿帕替尼治疗，联合组给予自拟抑癌汤联合阿帕替尼治疗，比较两组临床疗效、治疗前后血清CEA、CA199水平及毒副反应发生情况。结果 联合组肿瘤控制率为91.30%、治疗有效率为78.26%，高于西药组的73.91%、56.52%，差异有统计学意义（P＜0.05）；联合组血清CEA、CA199水平低于西药组，差异有统计学意义（P＜0.05）；联合组毒副反应总发生率为13.04%，低于西药组的34.78%，差异有统计学意义（P＜0.05）。结论 自拟抑癌汤联合阿帕替尼治疗中晚期胃癌患者疗效理想，可降低血清CEA、CA199水平，且毒副反应发生率低，用药安全性高。
Abstract:
Objective To investigate the effect of self-madeanticancer soupcombined with apatinib on patients with advanced gastric cancer and its effect on serum CEA and CA199.Methods A total of 46 patients with advanced gastric cancer who were treated in our hospital from July 2016 to August 2018 were selected and divided into western medicine group and combination group according to different treatment methods, with 23 cases in each group.The western medicine group was treated with apatinib, and the combination group was treated with self-madeanticancer soup combined with apatinib. The clinical efficacy and serum CEA and CA199 levels and the occurrence of toxic and side effects before and after treatment were compared between the two groups.Results The tumor control rate of the combined group was 91.30%, and the effective rate of treatment was 78.26%, which was higher than 73.91% and 56.52% of the western medicine group,the difference was statistically significant(P<0.05);The serum CEA and CA199 levels in the combination group were lower than those in the western medicine group,the difference was statistically significant (P＜0.05); The total incidence of side effects in the combined group was 13.04%, which was lower than 34.78% in the western medicine group,the difference was statistically significant(P<0.05).Conclusion The self-madeanticancer soupcombined with apatinib has an ideal effect in the treatment of patients with advanced gastric cancer. It can reduce serum CEA and CA199 levels, and has a low incidence of toxicity and high drug safety.

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更新日期/Last Update: 1900-01-01