[1]陈超逸,赵弯弯,黄 婷,等.NGAL与急性肾损伤患者的临床相关性分析[J].医学信息,2021,34(15):50-53.[doi:10.3969/j.issn.1006-1959.2021.15.014]
　CHEN Chao-yi,ZHAO Wan-wan,HUANG Ting,et al.Analysis of Clinical Correlation Between NGAL and Acute Kidney Injury[J].Medical Information,2021,34(15):50-53.[doi:10.3969/j.issn.1006-1959.2021.15.014]
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NGAL与急性肾损伤患者的临床相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年15期
页码:
50-53
栏目:
论著
出版日期:
2021-08-01

文章信息/Info

Title:
Analysis of Clinical Correlation Between NGAL and Acute Kidney Injury
文章编号:
1006-1959（2021）15-0050-04
作者:
陈超逸; 赵弯弯; 黄 婷; 等
（安徽医科大学附属省立医院肾脏内科，安徽 合肥 230000）
Author(s):
CHEN Chao-yi; ZHAO Wan-wan; HUANG Ting; et al.
(Department of Nephrology,Provincial Hospital Affiliated to Anhui Medical University,Hefei 230000,Anhui,China)
关键词:
急性肾损伤; 中性粒细胞明胶酶相关脂质运载蛋白; 微球蛋白; Scr
Keywords:
Acute kidney injury; Neutrophil gelatinase-associated lipocalin;  Microglobulin; Scr
分类号:
R692
DOI:
10.3969/j.issn.1006-1959.2021.15.014
文献标志码:
A
摘要:
目的 探讨血浆和尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平与急性肾损伤患者（AKI）临床指标的相关性及意义。方法 选取2017年11月~2020年12月安徽省立医院收治的21例AKI患者为AKI组，另选取同期我院体检中心的健康体检人群23例作为健康对照组，采用粒子增强免疫比浊法检测血浆NGAL、尿NGAL水平，分析血浆、尿NGAL与AKI患者临床指标的相关性。结果 两组年龄、性别、体质量指数、甘油三酯、空腹血糖比较，差异无统计学意义（P＞0.05）；AKI组Scr水平高于健康对照组，差异有统计学意义（P＜0.05）；AKI组血浆NGAL、尿NGAL水平高于健康对照组，差异有统计学意义（P＜0.05）；AKI患者血浆NGAL与Scr呈正相关（r=0.568，P＜0.05），与24 h尿量无相关性（r=0.041，P＞0.05），AKI患者尿NGAL与Scr呈正相关（r=0.653，P＜0.05），与24 h尿量无相关性（r=-0.001，P＞0.05）；AKI患者血浆NGAL与尿α1微球蛋白、尿β2微球蛋白、血β2微球蛋白、尿素氮、尿酸、白细胞计数、中性粒百分比、CRP、免疫球蛋白+补体无相关性（P＞0.05）；AKI患者尿NGAL与尿α1微球蛋白、尿β2微球蛋白、血β2微球蛋白呈正相关（r=0.669、0.652、0.514，P＜0.05），与尿素氮、尿酸、白细胞计数、中性粒百分比、CRP、免疫球蛋白、补体无相关性（P＞0.05）。结论 AKI患者血浆、尿NGAL水平升高，且与Scr呈正相关，尿NGAL、尿α1微球蛋白、尿β2微球蛋白、血β2微球蛋白与AKI的发生有一定的相关性，可作为预测AKI发生的生物标志物。
Abstract:
Objective To investigate the correlation and significance of plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) detection levels and clinical indicators in patients with acute kidney injury (AKI).Methods A total of 21 AKI patients admitted to Anhui Provincial Hospital from November 2017 to December 2020 were selected as the AKI group.In addition, 23 healthy people from the physical examination center of our hospital during the same period were selected as the healthy control group, and the plasma NGAL and urine NGAL levels were detected by the particle-enhanced immunoturbidimetric method.Analyze the correlation between plasma and urine NGAL and clinical indicators of AKI patients.Results There was no significant difference in age, gender, body mass index, triglycerides, and fasting blood glucose between the two groups (P>0.05).The Scr level of the AKI group was higher than that of the healthy control group,the difference was statistically significant (P＜0.05);The levels of plasma NGAL and urine NGAL in the AKI group were higher than those in the healthy control group,the difference was statistically significant (P＜0.05);Plasma NGAL in patients with AKI was positively correlated with Scr (r=0.568, P＜0.05), and there was no correlation with 24h urine output (r=0.041, P＞0.05).Urinary NGAL and Scr in AKI patients were positively correlated (r=0.653, P＜0.05),There was no correlation with 24h urine output (r=-0.001, P>0.05);There was no correlation between plasma NGAL in patients with AKI and urine α1 microglobulin, urine β2 microglobulin, blood β2 microglobulin, urea nitrogen, uric acid, white blood cell count, percentage of neutrophils, CRP, immunoglobulin + complement (P>0.05);Urine NGAL in patients with AKI was positively correlated with urine α1 microglobulin, urine β2 microglobulin, and blood β2microglobulin (r=0.669, 0.652, 0.514,P＜0.05).There was no correlation with urea nitrogen, uric acid, white blood cell count, neutrophil percentage, CRP, immunoglobulin, complement (P>0.05).Conclusion Plasma and urine NGAL levels in AKI patients are significantly increased, and are positively correlated with Scr.Urine NGAL, urine α1 microglobulin, urine β2 microglobulin, blood β2 microglobulin have a certain correlation with the occurrence of AKI, and can be used as biomarkers to predict the occurrence of AKI.

参考文献/References:

[1]Ricci Z,Romagnoli S.Acute Kidney Injury:Diagnosis and Classification in Adults and Children[J].Contrib Nephrol,2018(193):1-12. [2]Simonov M,Ugwuowo U,Moreira E,et al.A simple real-time model for predicting acute kidney injury in hospitalized patients in the US:A descriptive modeling study[J].PLoS Med,2019,16(7):e1002861. [3]Peng H,Wang Q,Lou T,et al.Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys[J].Nat Commun,2017,8(1):1493. [4]Khwaja A.Kdigo clinical practice guidelines for acute kidney injury[J].Nephron Clin Pract,2012,120(4):c179-c184. [5]Vanmassenhove J,Vanbiesen W,Vanholder R,et al.Subclinical AKI:ready for primetime in clinical practice[J].J Nephrol,2019,32(1):9-16. [6]Roy JP,Devarajan P.Acute Kidney Injury: Diagnosis and Management[J].Indian J Pediatr,2020,87(8):600-607. [7]Shang W,Wang Z.The Update of NGAL in Acute Kidney Injury[J].Curr Protein Pept Sci,2017,18(12):1211-1217. [8]Cowland JB,Borregaard N.Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans[J].Genomics,1997,45(1):17-23. [9]Zhang YL,Qiao SK,Wang RY,et al.NGAL attenuates renal ischemia/reperfusion injury through autophagy activation and apoptosis inhibition in rats[J].Chem Biol Interact,2018(289):40-46. [10]Sancho-martinez SM,Blanco-gozalo V,Quiros Y,et al.Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats[J].Toxicol Sci,2020,175(1):75-86. [11]Garimella PS,Lee AK,Ambrosius WT,et al.Markers of kidney tubule function and risk of cardiovascular disease events and mortality in the SPRINT trial[J].Eur Heart J,2019,40(42):3486-3493. [12]Duraj FF,Backman L,Dati F,et al.Serum levels of alpha-1 microglobulin and beta-2 microglobulin in bone marrow transplant recipients treated with cyclosporin A[J].Transpl Int,1991,4(3):146-50. [13]Joyce E,Glasner P,Ranganathan S,et al.Tubulointerstitial nephritis:diagnosis,treatment,andmonitoring[J].Pediatr Nephrol,2017,32(4):577-587. [14]Ho J,Lucy M,Krokhin O,et al.Mass spectrometry-based proteomic analysis of urine in acute kidney injury following cardiopulmonary bypass:a nested case-control study[J].Am J Kidney Dis,2009,53(4):584-595. [15]Pedersen KR,Ravn HB,Hjortdal VE,et al.Neutrophil gelatinase-associated lipocalin(NGAL):validation of commercially available ELISA[J].Scand J Clin Lab Invest,2010,70(5):374-382. [16]Wang J,Zhu HH,Xue JH,et al.Effects of storage conditions on the stability of serum CD163, NGAL, HMGB1 and MIP2[J].Int J Clin Exp Pathol,2015,8(4):4099-4105. [17]Schuh MP,Nehus E,Ma Q,et al.Long-term Stability of Urinary Biomarkers of Acute Kidney Injury in Children[J].Am J Kidney Dis,2016,67(1):56-61.

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更新日期/Last Update: 1900-01-01