[1]贾红芳,董林森,李文芳.尤瑞克林联合丁苯酞治疗急性缺血性脑卒中的效果及对神经功能的影响[J].医学信息,2021,34(22):139-141.[doi:10.3969/j.issn.1006-1959.2021.22.043]
　JIA Hong-fang,DONG Lin-sen,LI Wen-fang.Effect of Urinary Kallidinogenase Combined with Butylphthalide on Acute Ischemic Stroke and its Effect on Neurological Function[J].Medical Information,2021,34(22):139-141.[doi:10.3969/j.issn.1006-1959.2021.22.043]
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尤瑞克林联合丁苯酞治疗急性缺血性脑卒中的效果及对神经功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年22期
页码:
139-141
栏目:
药物与临床
出版日期:
2021-11-15

文章信息/Info

Title:
Effect of Urinary Kallidinogenase Combined with Butylphthalide on Acute Ischemic Stroke and its Effect on Neurological Function
文章编号:
1006-1959（2021）22-0139-03
作者:
贾红芳; 董林森; 李文芳
（天津康复疗养中心神经内科1，重症医学科2，疗二科3，天津 300381）
Author(s):
JIA Hong-fang; DONG Lin-sen; LI Wen-fang
(Department of Neurology1,Department of Critical Care Medicine2,the Second Department of Oncology3,Tianjin Rehabilitation Center,Tianjin 300381,China)
关键词:
尤瑞克林; 丁苯酞; 急性缺血性脑卒中
Keywords:
rinary Kallidinogenase;  Butylphthalide; Acute ischemic stroke
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2021.22.043
文献标志码:
A
摘要:
目的 研究尤瑞克林、丁苯酞治疗急性缺血性脑卒中的临床效果。方法 选取2019年10月-2020年10月我院诊治108例急性缺血性脑卒中患者为研究对象，采用随机数字表法分为对照组和观察组，各54例。对照组给予尤瑞克林治疗，观察组在对照组基础上给予丁苯酞治疗，比较两组临床治疗疗效、NIHSS评分、Barthel指数、GQOLI-74评分、临床不良反应及并发症发生情况。结果 观察组临床治疗总有效率为90.74%，高于对照组的79.62%，但差异无统计学意义（P＞0.05）；两组治疗后NIHSS评分低于治疗前，Barthel指数、GQOLI-74评分高于治疗前，且观察组NIHSS评分低于对照组，Barthel指数、GQOLI-74评分高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为5.56%，低于对照组的7.41%，差异无统计学意义（P＞0.05）；观察组并发症发生率为9.25%，低于对照组的16.67%，差异无统计学意义（P＞0.05）。结论 尤瑞克林联合丁苯酞治疗急性缺血性脑卒中效果优于单纯尤瑞克林治疗，可提高临床治疗总有效率，降低神经功能缺损评分，促进神经功能恢复，提高日常生活能力，改善生活质量，且联合应用不会增加临床不良反应和并发症发生几率，应用安全可靠。
Abstract:
Objective To study the clinical effect of urinary kallidinogenase and butylphthalide in the treatment of acute ischemic stroke.Methods A total of 108 patients with acute ischemic stroke diagnosed and treated in our hospital from October 2019 to October 2020 were selected as the study subjects. They were divided into control group and observation group by random number table method, with 54 cases in each group. The control group was treated with urinary kallidinogenase, and the observation group was treated with butylphthalide on the basis of the control group. The clinical efficacy, NIHSS score, Barthel index, GQOLI-74 score, clinical adverse reactions and complications of the two groups were compared.Results The total effective rate of clinical treatment in the observation group was 90.74%, which was higher than 79.62% in the control group, but the difference was not statistically significant (P>0.05). After treatment, the NIHSS scores of the two groups were lower than those before treatment, the Barthel index and GQOLI-74 scores were higher than those before treatment, and the NIHSS scores of the observation group were lower than those of the control group, while the Barthel index and GQOLI-74 scores were higher than those of the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 5.56%, which was lower than 7.41% in the control group, and the difference was not statistically significant (P>0.05). The incidence of complications in the observation group was 9.25%, which was lower than 16.67% in the control group, and the difference was not statistically significant (P>0.05).Conclusion The therapeutic effect of urinary kallidinogenase combined with butylphthalide in the treatment of acute ischemic stroke is better than that of simple therapy, which can increase the total effective rate of clinical treatment, decrease the score of neural function defect, promote the recovery of neural function, and improve the ability of daily living and the quality of life, and the combined use will not increase the incidence of clinical adverse effects and complications, the use of safe and reliable.

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更新日期/Last Update: 1900-01-01