[1]娄永忠,王 涛,郭筱菲,等.丁苯酞对缺血性脑卒中患者神经功能缺损程度影响的临床研究[J].医学信息,2022,35(04):115-117.[doi:10.3969/j.issn.1006-1959.2022.04.028]
　LOU Yong-zhong,WANG Tao,GUO Xiao-fei,et al.Clinical Study on the Effect of Butylphthalide on Neurological Deficits in Patients with Ischemic Stroke[J].Medical Information,2022,35(04):115-117.[doi:10.3969/j.issn.1006-1959.2022.04.028]
点击复制

丁苯酞对缺血性脑卒中患者神经功能缺损程度影响的临床研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
115-117
栏目:
论著
出版日期:
2022-02-15

文章信息/Info

Title:
Clinical Study on the Effect of Butylphthalide on Neurological Deficits in Patients with Ischemic Stroke
文章编号:
1006-1959（2022）04-0115-03
作者:
娄永忠; 王 涛; 郭筱菲; 李 斌
天津市滨海新区海滨人民医院神经医学科，天津 300450
Author(s):
LOU Yong-zhong; WANG Tao; GUO Xiao-fei; LI Bin
Department of Neurology,Haibin People’s Hospital of Binhai New Area,Tianjin 300450,China
关键词:
丁苯酞; 缺血性脑卒中; 神经功能缺损
Keywords:
Butylphthalide; Ischemic stroke; Nerve function defect
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.04.028
文献标志码:
A
摘要:
目的 评价丁苯酞氯化钠注射液治疗缺血性脑卒中的安全性和有效性。方法 选取2019年4月-2020年4月在我院诊治的124例缺血性脑卒中患者为研究对象，采用随机数字表法分为试验组和对照组，各62例。两组均给予基础治疗，试验组在此基础上加用丁苯酞氯化钠注射液，对照组在基础治疗上给予等量生理盐水。比较两组神经功能缺损评分（NIHSS）、联合血管事件发生率、日常生活自理能力评分、不良反应发生率及不同随访时间复发率。结果 两组NIHSS评分均降低，且试验组低于对照组（P＜0.05）；试验组联合血管事件发生率为12.90%，与对照组的9.68%比较，差异无统计学意义（P＞0.05）；两组日常生活自理能力评分高于治疗前，且试验组高于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）；随访3、6、12个月，试验组总复发率均小于对照组（P＜0.05）。结论 丁苯酞治疗缺血性脑卒中效果确切，可降低神经功能缺损评分，促进神经功能恢复，提高患者日常生活能力，降低远期复发率，且不增加联合血管事件和不良反应。
Abstract:
Objective To evaluate the safety and efficacy of butylphthalide and sodium chloride injection in the treatment of ischemic stroke.Methods A total of 124 patients with ischemic stroke treated in our hospital from April 2019 to April 2020 were selected and randomly divided into experimental group and control group, with 62 cases in each group. Both groups were given basic treatment, and the experimental group was given butylphthalide sodium chloride injection on the basis of the basic treatment, while the control group was given the same amount of normal saline. The neurological deficit score (NIHSS), incidence of combined vascular events, daily living self-care ability score, incidence of adverse reactions and recurrence rate at different follow-up time were compared between the two groups.Results The NIHSS scores of the two groups decreased, and the experimental group was lower than that in the control group (P<0.05). The incidence of combined vascular events in the experimental group was 12.90%, which was not significantly different from 9.68% in the control group (P>0.05). The scores of daily living self-care ability in the two groups were higher than those before treatment, and those in the experimental group were higher than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). After 3, 6, 12 months of follow-up, the total recurrence rate of the experimental group was higher than that of the control group (P<0.05).Conclusion Butylphthalide is effective in the treatment of ischemic stroke, which can reduce the neurological deficit score, promote the recovery of neurological function, improve the daily living ability of patients, reduce the long-term recurrence rate, and do not increase the combined vascular events and adverse reactions.

参考文献/References:

[1]陈娜,陆连生,李虹,等.丁苯酞序贯治疗急性脑梗死合并认知功能障碍患者的疗效及其对炎性因子的影响[J].疑难病杂志,2017,16(2):117-120,126[2]焦洋,王君,曾文斌.丁苯酞与依达拉奉联合治疗急性脑梗死的临床观察[J].陕西医学杂志,2017,46(1):108-109[3]李育英,陈英道,张岐平,等.丁苯酞联合依达拉奉治疗急性脑梗死60例临床研究[J].解放军医药杂志,2017,29(2):86-90[4]徐红强,王艳玲,孙利民.丁苯酞联合奥拉西坦治疗对急性脑梗死伴非痴呆型认知功能障碍的影响[J].中国实用神经疾病杂志,2017,20(4):19-21.[5]陈光生,林伯昌,朱伟明,等.丁苯酞软胶囊治疗急性脑梗死的疗效观察[J].现代药物与临床,2017,32(8):1429-1432.[6]Sun Y,Cheng X,Wang H,et al.dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats[J].Behav Brain Res,2017(329):67-74.[7]戴文卓,孔岳南.前列地尔联合丁苯肽对缺血性脑卒中患者血清炎症因子及凝血功能的影响[J].海南医学院学报,2016,22(12):1276-1278.[8]王陇德,王金环,彭斌,等.《中国脑卒中防治报告2016》概要[J].中国脑血管病杂志,2017,14(4):217-224.[9]刘树新,杨晓瑜.丁苯酞软胶囊对急性缺血性脑血管病的治疗效果[J].中西医结合心血管病电子杂志,2017,5(27):62.[10]Powers WJ,Rabinstein AA,Ackerson T,et al.2018 guidelines for the early management of patients with acute ischemic stroke: Aguideline for healthcare professionals from the American Heart Association /American Stroke Association[J].Stroke,2018,49(3):e46-e110.[11]孔起良,刘娟,杨震,等.早期使用丁苯酞注射液治疗基底节区脑梗死对侧支循环建立及神经功能的影响[J].临床神经病学杂志,2016,29(4):293-295.[12]Jiang Y,Sun L,Xuan X.Impacts of N-Butylphthalide on expression of growth factors in rats with focal cerebral ischemia[J].Bosn J Basic Med Sci,2016,16(2):102-107.[13]郑峥,陈兴泳,程琼,等.丁苯酞注射液治疗进展性脑卒中的疗效及安全性研究[J].中国全科医学,2016,19(3):322-326.[14]林亚楠,张亚,王玉,等.丁苯酞治疗大面积脑梗死的临床观察[J].中国新药杂志,2017,26(6):656-660.[15]周伟,张荣,周桂英,等.丁苯酞对急性脑梗死患者轻度认知功能障碍及神经功能缺损的影响[J].宁夏医科大学学报,2016,38(10):1210-1212.[16]李静,陈松,吕传柱,等.中国急性缺血性脑卒中急诊诊治专家共识院前急救解读[J].中国急救医学,2018,38(11):946-949.[17]Yan H,Yan Z,Niu X,et al.Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: Aprospective intervention study[J].Neurol Res,2017,39(4):337-343.[18]武星,王珅,方庆娟,等.丁苯酞软胶囊对急性缺血性脑血管病的治疗效果[J].宁夏医科大学学报,2017,39(5):576-578.[19]王义振,孙秋瑞.丁苯酞软胶囊联合尿激酶溶栓治疗急性脑梗死的效果分析[J].中外医学研究,2016,14(14):136-137.[20]慕晓辉.研究丁苯酞软胶囊联合尿激酶溶栓治疗急性脑梗死的效果[J].中国继续医学教育,2016,8(28):148-149.

相似文献/References:

[1]上官建辉,唐春燕.老年性缺血性脑卒中后抑郁干预治疗对神经功能恢复的疗效分析[J].医学信息,2019,32(03):125.[doi:10.3969/j.issn.1006-1959.2019.03.040]
　SHANGGUAN Jian-hui,TANG Chun-yan.Effect of Intervention Therapy on Neurologic Function Recovery after Senile Ischemic Cerebral Apoplexy[J].Medical Information,2019,32(04):125.[doi:10.3969/j.issn.1006-1959.2019.03.040]
[2]宫园园.LDL、Hcy、D-二聚体及颈动脉粥样硬化与急性缺血性脑卒中相关性研究[J].医学信息,2019,32(05):117.[doi:10.3969/j.issn.1006-1959.2019.05.036]
　GONG Yuan-yuan.Correlation between LDL,Hcy,D-dimer and Carotid Atherosclerosis and Acute Ischemic Stroke[J].Medical Information,2019,32(04):117.[doi:10.3969/j.issn.1006-1959.2019.05.036]
[3]褚春沐.丁苯酞序贯治疗对急性进展性脑梗死患者神经功能、炎症因子及Hcy、NSE的影响[J].医学信息,2022,35(17):129.[doi:10.3969/j.issn.1006-1959.2022.17.035]
　CHU Chun-mu.Effect of Butylphthalide Sequential Therapy on Neurological Function, Inflammatory Factors, Hcy and NSE in Patients with Acute Progressive Cerebral Infarction[J].Medical Information,2022,35(04):129.[doi:10.3969/j.issn.1006-1959.2022.17.035]
[4]褚春沐.雷贝拉唑治疗进展性缺血性脑卒中的价值[J].医学信息,2022,35(14):122.[doi:10.3969/j.issn.1006-1959.2022.14.030]
　CHU Chun-mu.Value of Rabeprazole in Treatment of Progressive Ischemic Stroke[J].Medical Information,2022,35(04):122.[doi:10.3969/j.issn.1006-1959.2022.14.030]
[5]张利山.缺血性脑卒中后癫痫发作的临床特点及治疗研究[J].医学信息,2019,32(18):38.[doi:10.3969/j.issn.1006-1959.2019.18.013]
　ZHANG Li-shan.Study on the Clinical Features and Treatment of Seizures after Ischemic Stroke[J].Medical Information,2019,32(04):38.[doi:10.3969/j.issn.1006-1959.2019.18.013]
[6]张志颖.老年女性内源性循环雌二醇和卒中风险的研究[J].医学信息,2019,32(22):84.[doi:10.3969/j.issn.1006-1959.2019.22.025]
　ZHANG Zhi-ying.Study on Endogenous Circulating Estradiol and Stroke Risk in Elderly Women[J].Medical Information,2019,32(04):84.[doi:10.3969/j.issn.1006-1959.2019.22.025]
[7]李 丹.丁苯酞联合银杏达莫治疗急性脑梗死的疗效[J].医学信息,2020,33(05):161.[doi:10.3969/j.issn.1006-1959.2020.05.053]
　LI Dan.Efficacy of Butylphthalide Combined with Ginkgo Leaf Extract and Dipyridamole in the Treatment of Acute Cerebral Infarction[J].Medical Information,2020,33(04):161.[doi:10.3969/j.issn.1006-1959.2020.05.053]
[8]赵林珊,刘 兴,耿 瑜.丁苯酞注射液治疗急性前循环脑梗死的效果[J].医学信息,2020,33(13):113.[doi:10.3969/j.issn.1006-1959.2020.13.032]
　ZHAO Lin-shan,LIU Xing,GENG Yu.Effect of Butylphthalide Injection on Acute Anterior Circulation Cerebral Infarction[J].Medical Information,2020,33(04):113.[doi:10.3969/j.issn.1006-1959.2020.13.032]
[9]韩 笑.抗氧化剂和B族维生素对缺血性脑卒中和脑动脉粥样硬化患者发病的影响[J].医学信息,2022,35(20):127.[doi:10.3969/j.issn.1006-1959.2022.20.034]
　HAN Xiao.Effects of Antioxidants and B Vitamins on Ischemic Stroke and Cerebral Atherosclerosis[J].Medical Information,2022,35(04):127.[doi:10.3969/j.issn.1006-1959.2022.20.034]
[10]肖 伟,余巨明.缺血性卒中后认知障碍相关可控因素的研究进展[J].医学信息,2020,33(21):35.[doi:10.3969/j.issn.1006-1959.2020.21.011]
　XIAO Wei,YU Ju-ming.Research Progress on the Related Controllable Factors of Cognitive Impairment After Ischemic Stroke[J].Medical Information,2020,33(04):35.[doi:10.3969/j.issn.1006-1959.2020.21.011]

更新日期/Last Update: 1900-01-01