[1]杨 许,吴书胜,闫 滢,等.胃癌术前外周血NLR、PLR、FIB与术后发生卵巢转移时间的相关性分析[J].医学信息,2021,34(23):39-43.[doi:10.3969/j.issn.1006-1959.2021.23.011]
　YANG Xu,WU Shu-sheng,YAN Ying,et al.Correlation Analysis Between Preoperative Peripheral Blood NLR,PLR,FIB and Postoperative Ovarian Metastasis Time of Gastric Cancer[J].Medical Information,2021,34(23):39-43.[doi:10.3969/j.issn.1006-1959.2021.23.011]
点击复制

胃癌术前外周血NLR、PLR、FIB与术后发生卵巢转移时间的相关性分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
39-43
栏目:
论著
出版日期:
2021-12-01

文章信息/Info

Title:
Correlation Analysis Between Preoperative Peripheral Blood NLR,PLR,FIB and Postoperative Ovarian Metastasis Time of Gastric Cancer
文章编号:
1006-1959（2021）23-0039-05
作者:
杨 许; 吴书胜; 闫 滢; 等
（1.新乡医学院附属省立医院肿瘤化疗科，河南 新乡 453000；2.中国科学技术大学附属第一医院西区/安徽省肿瘤医院肿瘤内科一病区，安徽 合肥 230000）
Author(s):
YANG Xu; WU Shu-sheng; YAN Ying; et al.
(1.Department of Oncology and Chemotherapy,Provincial Hospital Affiliated to Xinxiang Medical College,Xinxiang 453000,Henan,China;2.First Ward of Oncology Department,the First Affiliated Hospital of University of Science and Technology of China West District/Anhui Provincial Cancer Hospital,Hefei 230000,Anhui,China)
关键词:
胃癌; 卵巢转移癌; 中性粒细胞与淋巴细胞比值; 血小板与淋巴细胞比值; 纤维蛋白原
Keywords:
Gastric cancer; Ovarian metastasis; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Fibrinogen
分类号:
R735.2
DOI:
10.3969/j.issn.1006-1959.2021.23.011
文献标志码:
A
摘要:
目的 探索胃癌患者胃原发灶切除手术前外周血中性粒细胞/淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、血浆纤维蛋白原水平（FIB）及临床病理特征与术后发生卵巢转移时间的相关性。方法 回顾性分析2016年1月-2019年9月安徽省立医院收治的胃癌术后发生卵巢转移患者49例的临床病理资料，分析其外周血NLR、PLR、FIB及临床病理特征与胃癌原发灶手术至术后发生卵巢转移时间的相关性。结果 所有患者胃癌原发灶切除手术时间至首次发生卵巢转移的中位时间为19.43个月；单因素分析显示，不同年龄、原发灶部位、原发灶大小、T分期、N分期、手术方式、术前PLR的患者手术至卵巢转移时间比较，差异无统计学意义（P＞0.05）；弥漫型胃癌、术前高NLR、术前高FIB水平的患者手术至卵巢转移时间短于肠型胃癌、术前低NLR、术前低FIB水平的患者，差异有统计学意义（P＜0.05）；多因素分析显示，原发灶Lauren分型、术前外周血NLR是影响胃癌术后发生卵巢转移时间的独立影响因素。结论 胃癌患者术前外周血NLR升高、FIB升高及弥漫型胃癌患者可能发生卵巢转移的时间较早，胃癌原发灶术后Lauren分型、术前外周血NLR可能是影响胃癌术后发生卵巢转移的独立危险因素。
Abstract:
Objective To explore the correlation between peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), plasma fibrinogen level (FIB), clinical pathological features and postoperative ovarian metastasis time in patients with gastric cancer before gastrectomy.Methods The clinicopathological data of 49 patients with ovarian metastasis after gastric cancer surgery admitted to Anhui Provincial Hospital from January 2016 to September 2019 were retrospectively analyzed. The correlation between peripheral blood NLR, PLR, FIB and clinicopathological characteristics and the time of ovarian metastasis from primary gastric cancer surgery to postoperative was analyzed.Results The median time from resection of primary gastric cancer to the first occurrence of ovarian metastasis in all patients was 19.43 months ; univariate analysis showed that there was no significant difference in the time from surgery to ovarian metastasis among patients with different ages, primary sites, primary sizes, T staging, N staging, surgical methods, and preoperative PLR (P>0.05). Patients with diffuse gastric cancer, preoperative high NLR and preoperative high FIB had shorter ovarian metastasis time than those with intestinal gastric cancer, preoperative low NLR and preoperative low FIB, and the differences were statistically significant (P<0.05). Multivariate analysis showed that Lauren classification of primary tumor and preoperative peripheral blood NLR were independent factors affecting the time of ovarian metastasis after gastric cancer surgery.Conclusion The increase of NLR and FIB in patients with gastric cancer before operation and the patients with diffuse-type gastric cancer may have ovarian metastasis earlier, and the postoperative Lauren typing and preoperative peripheral blood NLR may be the independent risk factors of ovarian metastasis in patients with gastric cancer.

参考文献/References:

[1]Sung H,Ferlay J,Siegel RL,et al.Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J].CA Cancer J Clin,2021,71(3):209-249.[2]Kubecek O,Laco J,Spacek J,et al.The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review[J].Clin Exp Metastasis,2017,34(5):295-307. [3]Jeung YJ,Ok HJ,Kim WG,et al.Krukenberg tumors of gastric origin versus colorectal origin[J].Obstet Gynecol Sci,2015,58(1):32-39.[4]朱学聪.血浆纤维蛋白原水平同胃癌肝转移临床病理参数的关系和预测疗效及预后的价值[D].石家庄:河北医科大学,2016.[5]Saito H,Kono Y,Murakami Y,et al.Prognostic Significance of Pre- and Postoperative Lymphocyte Counts in Patients with Gastric Cancer[J].Dig Surg,2019,36(2):137-143.[6]Yamamoto M,Kurokawa Y,Kobayashi N,et al.Prognostic Value of the Combined Index of Plasma Fibrinogen and the Neutrophil-Lymphocyte Ratio in Gastric Cancer[J].World J Surg,2020,44(1):207-212. [7]Yamamoto M,Kurokawa Y,Miyazaki Y,et al.Usefulness of Preoperative Plasma Fibrinogen Versus Other Prognostic Markers for Predicting Gastric Cancer Recurrence[J].World J Surg,2016,40(8):1904-1909.[8]田艳涛,马福海.胃癌卵巢转移的诊治策略[J].中华肿瘤杂志,2019,41(3):178-182.[9]Zhao G,Liu N,Wang S,et al.Prognostic significance of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in patients with metastatic gastric cancer[J].Medicine,2020,99(10):e19405.[10]Zhang X,Zhao W,Yu Y,et al.Clinicopathological and prognostic significance of platelet-lymphocyte ratio (PLR) in gastric cancer: an updated meta-analysis[J].World J Surg Oncol,2020,18(1):191. [11]Yamashita H,Kitayama J,Nagawa H.Hyperfibrinogenemia is a useful predictor for lymphatic metastasis in human gastric cancer[J].Jpn J Clin Oncol,2005,35(10):595-600. [12]Feng F,Liu J,Wang F,et al.Prognostic value of differentiation status in gastric cancer[J].BMC Cancer,2018,18(1):865.[13]Williams KA,Labidi-Galy SI,Terry KL,et al.Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer[J]. Gynecol Oncol,2014,132(3):542-550.[14]Hirahara T,Arigami T,Yanagita S,et al.Combined neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with advanced gastric cancer[J].BMC Cancer,2019,19(1):672.[15]邓中波.中性粒细胞与淋巴细胞比率在T4期胃癌患者中的应用研究[D].合肥:安徽医科大学,2019.[16]Shimada H,Takiguchi N,Kainuma O,et al.High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer[J].Gastric Cancer,2010,13(3):170-176.

相似文献/References:

[1]尹晓华,刘重元,黄 琳,等.胃癌中lncRNAs的研究进展[J].医学信息,2018,31(03):10.[doi:10.3969/j.issn.1006-1959.2018.03.004]
　YIN Xiao-hua,LIU Zhong-yuan,HUANG Lin,et al.Research Progress of lncRNAs in Gastric Cancer[J].Medical Information,2018,31(23):10.[doi:10.3969/j.issn.1006-1959.2018.03.004]
[2]芮昆昆,章 波,邰小华,等.基质金属蛋白酶2与蛋白磷酸酶2A的癌性抑制因子在胃癌中的研究进展[J].医学信息,2018,31(03):21.[doi:10.3969/j.issn.1006-1959.2018.03.007]
　RUI Kun-kun,ZHANG Bo,TAI Xiao-hua,et al.The Research Progress of Matrix Metalloproteinase 2 and Cancer Inhibitor of Protein Phosphatase 2A in Gastric Cancer[J].Medical Information,2018,31(23):21.[doi:10.3969/j.issn.1006-1959.2018.03.007]
[3]段 巍.1例晚期胃癌化疗并发嗜血细胞综合征患者的护理[J].医学信息,2018,31(10):181.[doi:10.3969/j.issn.1006-1959.2018.10.063]
　DUAN Wei.Nursing Care of a Case of Advanced Gastric Carcinoma with Hemophagocytic Syndrome after Chemotherapy[J].Medical Information,2018,31(23):181.[doi:10.3969/j.issn.1006-1959.2018.10.063]
[4]潘理会,李育庄,李春辉.胃癌与高凝血状态关系的研究现状[J].医学信息,2018,31(11):15.[doi:10.3969/j.issn.1006-1959.2018.11.005]
　PAN Li-hui,LI Yu-zhuang,LI Chun-hui.Research Status of the Relationship between Gastric Carcinoma and Hypercoagulable State[J].Medical Information,2018,31(23):15.[doi:10.3969/j.issn.1006-1959.2018.11.005]
[5]李虹霞,刘伏山.慢性萎缩性胃炎的中西医治疗[J].医学信息,2022,35(11):29.[doi:10.3969/j.issn.1006-1959.2022.11.009]
　LI Hong-Xia,LIU Fu-shan.Treatment of Chronic Atrophic Gastritis with Traditional Chinese and Western Medicine[J].Medical Information,2022,35(23):29.[doi:10.3969/j.issn.1006-1959.2022.11.009]
[6]梁延洋,程艳娜,华柏慧,等.胃癌合并2型糖尿病术后血糖改善的临床观察[J].医学信息,2018,31(17):187.[doi:10.3969/j.issn.1006-1959.2018.17.061]
　LIANG Yan-yang,CHENG Yan-na,HUA Bai-hui,et al.Clinical Observation of Postoperative Blood Glucose Improvement in Patients with Gastric Cancer Complicated with Type 2 Diabetes Mellitus[J].Medical Information,2018,31(23):187.[doi:10.3969/j.issn.1006-1959.2018.17.061]
[7]林跃韩,许庆文.腹腔镜uncut Roux-en-Y吻合与传统吻合方式的研究进展[J].医学信息,2018,31(22):31.[doi:10.3969/j.Ⅰssn.1006-1959.2018.22.010]
　LIN Yue-han,XU Qing-wen.Research Progress of Laparoscopic uncut Roux-en-Y Anastomosis and Traditional Anastomosis[J].Medical Information,2018,31(23):31.[doi:10.3969/j.Ⅰssn.1006-1959.2018.22.010]
[8]马玉涛,石文娜,李晓林,等.免疫荧光法检测FSHR与GnRHR在胃癌组织中的分布及其共定位研究[J].医学信息,2018,31(23):79.[doi:10.3969/j.issn.1006-1959.2018.23.022C]
　MA Yu-tao,SHI Wen-na,LI Xiao-lin,et al.Study on the Distribution and Co-localization of FSHR and GnRHR in Gastric Cancer Tissues by Immunofluorescence Assay[J].Medical Information,2018,31(23):79.[doi:10.3969/j.issn.1006-1959.2018.23.022C]
[9]赵 静.血浆纤维蛋白原和CA724水平在胃癌患者的变化及临床意义[J].医学信息,2018,31(24):82.[doi:10.3969/j.issn.1006-1959.2018.24.021]
　ZHAO Jing.Changes and Clinical Significance of Plasma Fibrinogen and CA724 Levels in Patients with Gastric Cancer[J].Medical Information,2018,31(23):82.[doi:10.3969/j.issn.1006-1959.2018.24.021]
[10]万 芳.以贫血为首发症状的消化道恶性肿瘤临床分析[J].医学信息,2018,31(24):175.[doi:10.3969/j.issn.1006-1959.2018.24.054]
　WAN Fang.Clinical Analysis of Digestive Tract Malignancies with Anemia as the First Symptom[J].Medical Information,2018,31(23):175.[doi:10.3969/j.issn.1006-1959.2018.24.054]

更新日期/Last Update: 1900-01-01