[1]廖 帅,刘 阳,曾令勇,等.高压氧治疗对弥漫性轴索损伤疗效和预后的Meta分析[J].医学信息,2022,35(02):94-99,104.[doi:10.3969/j.issn.1006-1959.2022.02.023]
　LIAO Shuai,LIU Yang,ZENG Ling-yong,et al.Meta Analysis of Curative Effect and Prognosis of Hyperbaric Oxygen Therapyfor Diffuse Axonal Injury[J].Medical Information,2022,35(02):94-99,104.[doi:10.3969/j.issn.1006-1959.2022.02.023]
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高压氧治疗对弥漫性轴索损伤疗效和预后的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
94-99,104
栏目:
论著
出版日期:
2022-01-15

文章信息/Info

Title:
Meta Analysis of Curative Effect and Prognosis of Hyperbaric Oxygen Therapyfor Diffuse Axonal Injury
文章编号:
1006-1959（2022）02-0094-07
作者:
廖 帅; 刘 阳; 曾令勇; 张 海; 徐剑峰
绵阳市第三人民医院神经外科，四川 绵阳 621000
Author(s):
LIAO Shuai; LIU Yang; ZENG Ling-yong; ZHANG Hai; XU Jian-feng
Department of Neurosurgery,the Third Hospital of Mianyang,Mianyang 621000,Sichuan,China
关键词:
弥漫性轴索损伤; 高压氧; 预后
Keywords:
Diffuse axonal injury; Hyperbaric oxygen therapy; Prognosis
分类号:
R651.1；R840.5
DOI:
10.3969/j.issn.1006-1959.2022.02.023
文献标志码:
A
摘要:
目的 对弥漫性轴索损伤（DAI）患者采取高压氧（HBO）治疗的效果和预后进行综合评价。方法 检索PubMed、The Cochrane Library、EMbase、WanFang Data、VIP、CNKI和CBM数据库，筛选采取HBO对比非HBO治疗DAI患者的随机对照试验（RCT），时间截止至2021年5月。采用RevMan5.3进行统计分析。结果 纳入文献12篇，共728例患者；HBO治疗组的清醒率高于对照组（RR=1.37，95%CI=1.22~1.54，P＜0.00001），意识恢复时间短于对照组（MD=-8.21，95%CI=-10.48~-5.95，P＜0.00001）；HBO治疗组6个月后GOS预后良好率高于对照组（RR=1.71，95%CI=1.45~2.02，P＜0.00001）；两组3个月后GOS预后良好率比较，差异无统计学意义（RR=1.60，95%CI=0.82~3.10，P=0.17）。结论 HBO治疗可以促进DAI患者的意识恢复，改善预后，但短时间内预后改善不明显，仍需标准相同、样本足够、多中心的高质量RCT来验证。
Abstract:
Objective To evaluate the effects and prognosis of hyperbaric oxygen (HBO) therapy on patients with diffuse axonal injury (DAI).Methods Searched Pubmed, The Cochrane Library, Embase, WanFang Data, VIP, CNKI and CBM databases to obtain randomized controlled trials (RCTs) of HBO versus non-HBO for DAI patients before May 2021. Two researchers independently selected literature, collected data and evaluated the risk of bias. Revman5.3 was used for statistical analysis.Results Totally 12 literature including 728 patients were selected. The awake rate of HBO treatment group was higher than that of control group (RR=1.37, 95%CI=1.22 to 1.54, P<0.00001), and the recovery time of consciousness was shorter than that of control group (MD=-8.21, 95%CI=-10.48 to -5.95, P<0.00001). The good prognosis rate of GOS after 6 months in HBO treatment group was higher than that in control group (RR=1.71, 95%CI=1.45 to 2.02, P<0.00001). There was no significant difference in good prognosis rate of GOS between the two groups after 3 months (RR=1.60, 95%CI=0.82 to 3.10, P=0.17).Conclusion HBO therapy may promote the recovery of consciousness and improve the prognosis for DAI patients, but it still needs RCT with uniform-standards, polycentric, sufficient-sample andexcellent-quality to verify this conclusion.

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