[1]郭玉玉,余 宋,翟笑枫.循环肿瘤DNA在食管癌诊治中的应用[J].医学信息,2022,35(07):41-44.[doi:10.3969/j.issn.1006-1959.2022.07.011]
 GUO Yu-yu,YU Song,ZHAI Xiao-feng.Application of Circulating Tumor DNA in the Diagnosis and Treatment of Esophageal Cancer[J].Medical Information,2022,35(07):41-44.[doi:10.3969/j.issn.1006-1959.2022.07.011]
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循环肿瘤DNA在食管癌诊治中的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年07期
页码:
41-44
栏目:
综述
出版日期:
2022-04-01

文章信息/Info

Title:
Application of Circulating Tumor DNA in the Diagnosis and Treatment of Esophageal Cancer
文章编号:
1006-1959(2022)07-0041-04
作者:
郭玉玉余 宋翟笑枫
(解放军海军军医大学第一附属医院中医肿瘤科,上海 200083)
Author(s):
GUO Yu-yuYU SongZHAI Xiao-feng
(Department of Traditional Chinese Medicine,the First Affiliated Hospital of People’s Liberation Army Navy Medical University,Shanghai 200083,China)
关键词:
食管癌循环肿瘤细胞循环肿瘤DNA
Keywords:
Esophageal cancerCirculating tumor cellsCirculating tumor DNA
分类号:
R735.1
DOI:
10.3969/j.issn.1006-1959.2022.07.011
文献标志码:
A
摘要:
食管癌是常见和致命的恶性肿瘤之一,目前普遍认为影响食管癌患者预后的因素主要分为肿瘤的分期分级、复发转移以及对患者治疗后的反应。肿瘤液态活检是目前最具发展潜力的肿瘤无创诊断和实时疗效监测手段,区别于传统的临床诊断手段,该方法具有方便、安全、无创、实时等特点,已广泛应用于多种肿瘤的诊断及预后。含肿瘤突变的循环肿瘤DNA(ctDNA)可以在疾病进展过程中多次检测,是一种简单有效的非侵入性液体活检技术。作为一种附加的诊断工具,ctDNA可以提供肿瘤负荷及肿瘤中存在的突变等诸多信息,并能克服组织活检所面临的肿瘤内异质性问题,在肿瘤的诊断和治疗中具有潜在的应用价值。本文就ctDNA概述及其在食管癌患者中的应用作一综述,以期为该疾病的临床治疗提供参考。
Abstract:
Esophageal cancer is one of the common and fatal malignant tumors. It is generally believed that the factors affecting the prognosis of esophageal cancer patients are mainly divided into tumors staging, recurrent metastasis, and responses to patients. Tumor liquid biopsy is currently the most promising non-invasive diagnostic and real-time monitoring method for tumor. Different from traditional clinical diagnostic methods, this method is convenient, safe, non-invasive and real-time, and has been widely used in the diagnosis and prognosis of various tumors. Circulating tumor DNA (ctDNA) containing tumor mutations can be repeatedly detected during disease progression, which is a simple and effective non-invasive liquid biopsy technology. As an additional diagnostic tool, ctDNA can provide many information such as tumor load and mutations in tumors, and can overcome the problem of intratumoral heterogeneity faced by tissue biopsy, which has potential application value in the diagnosis and treatment of tumors. This article reviews the overview of ctDNA and its application in patients with esophageal cancer, in order to provide reference for clinical treatment of the disease.

参考文献/References:

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更新日期/Last Update: 1900-01-01