[1]朱 滨,蒋晓宏.血清NSE、hs-CRP与头颅MRI在新生儿脑损伤严重程度的相关性研究[J].医学信息,2022,35(12):130-133.[doi:10.3969/j.issn.1006-1959.2022.12.031]
　ZHU Bin,JIANG Xiao-hong.Correlation Between Serum NSE, hs-CRP and Brain MRI in Neonatal Brain Injury Severity[J].Medical Information,2022,35(12):130-133.[doi:10.3969/j.issn.1006-1959.2022.12.031]
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血清NSE、hs-CRP与头颅MRI在新生儿脑损伤严重程度的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年12期
页码:
130-133
栏目:
论著
出版日期:
2022-06-15

文章信息/Info

Title:
Correlation Between Serum NSE, hs-CRP and Brain MRI in Neonatal Brain Injury Severity
文章编号:
1006-1959（2022）12-0130-04
作者:
朱 滨; 蒋晓宏
（安徽医科大学附属巢湖医院新生儿科，安徽 合肥 230000）
Author(s):
ZHU Bin; JIANG Xiao-hong
(Department of Neonatology,Chaohu Hospital Affiliated to Anhui Medical University,Hefei 230000,Anhui,China)
关键词:
新生儿; 脑损伤; 神经元特异性烯醇化酶; 超敏C反应蛋白
Keywords:
Newborns; Brain injury; Neuron-specific enolase; High-sensitivity C-reactive protein
分类号:
R722.1
DOI:
10.3969/j.issn.1006-1959.2022.12.031
文献标志码:
A
摘要:
目的 探讨新生儿脑损伤神经元特异性烯醇化酶（NSE）、超敏C反应蛋白（hs-CRP）变化与头颅MRI结果的相关性。方法 选取我院2019年6月-2021年6月新生儿科住院新生儿为研究对象，其中90例临床确诊的脑损伤新生儿为实验组，依据头颅MRI结果分为轻度组、中度组和重度组，各30例；另选取同期50例非脑损伤新生儿为对照组，比较各组入院血清NSE及hs-CRP值，分析各指标变化与新生儿脑损伤严重程度之间的关系。结果 重度组NSE与hs-CRP高于对照组、轻度组及中度组，差异有统计学意义（P＜0.05）；中度组NSE高于对照组及轻度组，差异有统计学意义（P＜0.05）；对照组与轻度组hs-CRP比较，差异无统计学意义（P＞0.05）；轻度组NSE、hs-CRP与对照组比较，差异无统计学意义（P＞0.05）；NSE、hs-CRP诊断重度新生儿脑损伤的ROC曲线下面积（AUC）分别为0.802、0.738；NSE为52.24 μg/L时，灵敏度为0.833，特异度为0.656，诊断价值最大，hs-CRP为0.60 mg/L时，灵敏度为0.767，特异度为0.644，诊断价值最大。结论 NSE、hs-CRP对明确新生儿脑损伤严重程度具有一定的价值，临床可检测两者以明确新生儿脑损伤情况。
Abstract:
Objective To investigate the correlation between the changes of neuron specific enolase (NSE), high-sensitivity C-reactive protein (hs-CRP) and brain MRI results in neonatal brain injury.Methods From June 2019 to June 2021, 90 neonates with clinically diagnosed brain injury were selected as the experimental group. According to the results of cranial MRI, they were divided into mild group, moderate group and severe group, with 30 cases in each group. At the same time, 50 newborns without brain injury were selected as the control group. The serum NSE and hs-CRP values of each group were compared, and the relationship between the changes of each index and the degree of neonatal brain injury was analyzed.Results NSE and hs-CRP in the severe group were higher than those in the control group, mild group and moderate group, and the difference was statistically significant (P<0.05); NSE in the moderate group was higher than that in the control group and the mild group, and the difference was statistically significant (P<0.05); there was no significant difference in hs-CRP between the control group and the mild group (P>0.05); there was no significant difference in NSE and hs-CRP between the mild group and the control group (P>0.05). The area under ROC curve (AUC) of NSE and hs-CRP in the diagnosis of severe neonatal brain injury was 0.802 and 0.738, respectively. When NSE was 52.24 μg/L, the sensitivity was 0.833, and the specificity was 0.656, with the highest diagnostic value. When hs-CRP was 0.60 mg/L, the sensitivity was 0.767, and the specificity was 0.644, with the highest diagnostic value.Conclusion NSE and hs-CRP have a certain value in identifying the severity of neonatal brain injury, and they can be detected clinically to identify neonatal brain injury.

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更新日期/Last Update: 1900-01-01