[1]张利敏,游 婕,朱陈华,等.脂联素和D-二聚体在急性主动脉夹层中的诊断价值[J].医学信息,2022,35(14):62-65.[doi:10.3969/j.issn.1006-1959.2022.14.013]
　ZHANG Li-min,YOU Jie,ZHU Chen-hua,et al.Diagnostic Value of Adiponectin and D-dimer in Acute Aortic Dissection[J].Medical Information,2022,35(14):62-65.[doi:10.3969/j.issn.1006-1959.2022.14.013]
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脂联素和D-二聚体在急性主动脉夹层中的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
62-65
栏目:
论著
出版日期:
2022-07-15

文章信息/Info

Title:
Diagnostic Value of Adiponectin and D-dimer in Acute Aortic Dissection
文章编号:
1006-1959（2022）14-0062-04
作者:
张利敏; 游 婕; 朱陈华; 等
（宜昌市第二人民医院检验科，湖北 宜昌 443000）
Author(s):
ZHANG Li-min; YOU Jie; ZHU Chen-hua; et al.
(Department of Laboratory Medicine,the Second People’s Hospital of Yichang,Yichang 443000,Hubie,China)
关键词:
急性主动脉夹层; D-二聚体; 脂联素
Keywords:
Acute aortic dissection; D-dimer; Adiponectin
分类号:
R543.1；R446.6
DOI:
10.3969/j.issn.1006-1959.2022.14.013
文献标志码:
A
摘要:
目的 探讨脂联素（APN）与D-二聚体在急性主动脉夹层（AAD）患者中的诊断价值。方法 选取2016年2月-2019年2月于我院急诊科就诊的AAD患者42例作为AAD组，另选取42名健康者作为对照组，检测两组血清APN及D-二聚体水平，比较两组甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白（HDL）、APN及D-二聚体水平，采用受试者工作特征（ROC）曲线分析APN及D-二聚体在AAD中的诊断价值。结果 AAD组D-二聚体水平高于对照组，APN水平低于对照组，差异有统计学意义（P＜0.05）；破裂型AAD患者D-二聚体水平高于稳定型AAD患者，APN水平低于稳定型AAD患者，差异有统计学意义（P＜0.05）；A型AAD患者D-二聚体水平高于B型AAD患者，APN水平低于B型患者，差异有统计学意义（P＜0.05）；ROC曲线显示，血清APN诊断AAD的AUC为0.857（95%CI：0.774~0.940，P＜0.05），最佳截断值为6.13 mg/L，敏感度为81.32%，特异度为95.71%，血清D-二聚体诊断AAD的AUC为0.787（95%CI：0.685~0.888，P＜0.05），最佳截断值为0.85 mg/L，敏感度为85.18%，特异度为84.47%。结论 AAD患者血清中APN水平降低，D-二聚体水平升高，血清APN及D-二聚体水平对AAD具有较好的诊断价值。
Abstract:
Objective To investigate the diagnostic value of adiponectin (APN) and D-dimer in patients with acute aortic dissection (AAD).Methods A total of 42 patients with AAD who were treated in the emergency department of our hospital from February 2016 to February 2019 were selected as the AAD group, and 42 healthy people were selected as the control group. The levels of serum APN and D-dimer were detected in the two groups. The levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein (HDL), APN and D-dimer were compared between the two groups. The diagnostic value of APN and D-dimer in AAD was analyzed by receiver operating characteristic (ROC) curve.Results D-dimer in the AAD group was higher than that in the control group, and APN level was lower than that in the control group, the difference was statistically significant (P<0.05). D-dimer level in patients with ruptured AAD was higher than that in patients with stable AAD, and APN level was lower than that in patients with stable AAD, the difference was statistically significant (P<0.05). The d-dimer level of patients with type A AAD was higher than that of patients with type B AAD, and the APN level was lower than that of patients with type B AAD, the difference was statistically significant (P<0.05). ROC curve showed that the AUC of serum APN in the diagnosis of AAD was 0.857 (95%CI:0.774-0.940, P<0.05), the optimal cut-off value was 6.13 mg/L, the sensitivity was 81.32%, and the specificity was 95.71%. The AUC of serum D-dimer in the diagnosis of AAD was 0.787 (95%CI: 0.685-0.888, P<0.05), the optimal cut-off value was 0.85 mg/L, the sensitivity was 85.18%, and the specificity was 84.47%.Conclusion The serum APN level in patients with AAD is decreased, and the D-dimer level is increased. The serum APN and D-dimer levels have good diagnostic value for AAD.

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更新日期/Last Update: 1900-01-01