[1]曹 冬.腹腔镜治疗肠癌的效果及对血清CEA水平的影响[J].医学信息,2022,35(16):86-89.[doi:10.3969/j.issn.1006-1959.2022.16.020]
　CAO Dong.The Effect of Laparoscopic Treatment of Colorectal Cancer and its Effect on Serum CEA Level[J].Journal of Medical Information,2022,35(16):86-89.[doi:10.3969/j.issn.1006-1959.2022.16.020]
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腹腔镜治疗肠癌的效果及对血清CEA水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
86-89
栏目:
论著
出版日期:
2022-08-15

文章信息/Info

Title:
The Effect of Laparoscopic Treatment of Colorectal Cancer and its Effect on Serum CEA Level
文章编号:
1006-1959（2022）16-0086-04
作者:
曹 冬
（瑞昌市人民医院普外科，江西 瑞昌 332200）
Author(s):
CAO Dong
(Department of General Surgery,Ruichang People’s Hospital,Ruichang 332200,Jiangxi,China)
关键词:
腹腔镜手术; 肠癌; 肿瘤标志物
Keywords:
Laparoscopic surgery; Bowel cancer; Tumor markers
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2022.16.020
文献标志码:
A
摘要:
目的 探讨腹腔镜治疗肠癌的效果及对血清中癌胚抗原（CEA）水平的影响。方法 选取2015年1月-2020年1月瑞昌市人民医院接受治疗的60例肠癌患者作为研究对象，根据随机数字表法分为对照组和观察组，各30例。对照组行常规开腹手术，观察组行腹腔镜手术，比较两组围术期相关指标、肿瘤标志物水平、术后恢复情况、并发症发生率及1年内生存情况。结果 观察组手术切口小于对照组，术中出血量少于对照组，引流管放置时间、住院时间短于对照组，差异有统计学意义（P＜0.05）；而两组手术时间比较，差异无统计学意义（P＞0.05）。观察组术后CEA、CA199、VEGF、MMP9水平低于对照组，差异有统计学意义（P＜0.05）。观察组肠鸣音恢复时间、术后排气时间、正常进食时间短于对照组，差异有统计学意义（P＜0.05）。观察组术后并发症总发生率为16.67%，低于对照组的40.00%，差异有统计学意义（P＜0.05）。观察组1年内复发/转移率低于对照组，但差异无统计学意义（P＞0.05）；而观察组1年内生存率高于对照组，差异有统计学意义（P＜0.05）。结论 腹腔镜手术可降低肠癌患者肿瘤标志物水平，促进患者术后恢复，且并发症发生几率低、生存率高。
Abstract:
Objective To investigate the effect of laparoscopy in the treatment of colorectal cancer and its influence on serum carcinoembryonic antigen (CEA) level.Methods A total of 60 patients with colorectal cancer who were treated in Ruichang People ’s Hospital from January 2015 to January 2020 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 30 cases in each group. The control group underwent routine laparotomy, and the observation group underwent laparoscopic surgery. The perioperative indicators, tumor marker levels, postoperative recovery, complication rate, and 1-year survival were compared between the two groups.Results The surgical incision of the observation group was smaller than that of the control group, the intraoperative blood loss was less than that of the control group, the drainage tube placement time and hospitalization time were shorter than those of the control group, and the differences were statistically significant (P<0.05); there was no significant difference in operation time between the two groups (P>0.05). The levels of CEA, CA199, VEGF and MMP9 in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The recovery time of bowel sounds, postoperative exhaust time and normal eating time in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). The total incidence of postoperative complications in the observation group was 16.67%, which was lower than 40.00% in the control group, the difference was statistically significant (P<0.05). The recurrence/metastasis rate in the observation group was lower than that in the control group within 1 year, but the difference was not statistically significant (P>0.05); the 1-year survival rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion Laparoscopic surgery can reduce the level of tumor markers in patients with colorectal cancer and promote postoperative recovery, with low incidence of complications and high survival rate.

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更新日期/Last Update: 1900-01-01