[1]张杏羡.化学发光免疫法对肿瘤生物标志物的检验效果分析[J].医学信息,2022,35(20):154-156.[doi:10.3969/j.issn.1006-1959.2022.20.043]
　ZHANG Xing-xian.Analysis of the Effect of Chemiluminescence Immunoassay on Tumor Biomarkers[J].Journal of Medical Information,2022,35(20):154-156.[doi:10.3969/j.issn.1006-1959.2022.20.043]
点击复制

化学发光免疫法对肿瘤生物标志物的检验效果分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
154-156
栏目:
诊疗技术
出版日期:
2022-10-15

文章信息/Info

Title:
Analysis of the Effect of Chemiluminescence Immunoassay on Tumor Biomarkers
文章编号:
1006-1959（2022）20-0154-03
作者:
张杏羡
（天津华兴医院检验科，天津 300270）
Author(s):
ZHANG Xing-xian
(Department of Laboratory,Tianjin Huaxing Hospital,Tianjin 300270,China)
关键词:
化学发光免疫法; 癌胚抗原; 甲胎蛋白; 糖链抗原-199; 糖链抗原-125
Keywords:
Chemiluminescence immunoassay; Carcinoembryonic antigen; Alpha-fetoprotein; Carbohydrate antigen-199; Carbohydrate antigen-125
分类号:
R446.6
DOI:
10.3969/j.issn.1006-1959.2022.20.043
文献标志码:
A
摘要:
目的 分析化学发光免疫法对肿瘤生物标志物的检验效果。方法 选择2021年1月-12月我院经病理学检验确诊的50例恶性肿瘤患者为观察组，另收集50例同期体检健康者为对照组。采集研究对象静脉血标本，通过化学发光免疫法检验其血清肿瘤生物标志物含量，包括癌胚抗原（CEA）、甲胎蛋白（AFP）、糖链抗原-199（CA-199）、糖链抗原-125（CA-125）与糖链抗原-153（CA-153），统计并分析其检验结果。结果 观察组CEA、AFP、CA-199、CA-125、CA-153水平高于对照组（P＜0.05）；观察组CEA、AFP、CA-199、CA-125、CA-153的阳性检出率高于对照组（P＜0.05）；CEA、AFP、CA-199、CA-125、CA-153在不同恶性肿瘤疾病中均有检出，其中CEA在肠癌中的阳性检出率最高，AFP在肝癌中的阳性检出率最高，CA-153在乳腺癌中的阳性检出率最高，CA-125在卵巢癌中的阳性检出率最高，其阳性检出率均为100.00%。结论 化学发光免疫法对肿瘤生物标志物具有较高的检出率，鉴别检验效果理想。
Abstract:
Objective To analyze the test effect of chemical luminescence immunoassay on tumor biomarkers.Methods From January to December 2021, 50 patients with malignant tumors diagnosed by pathological examination in our hospital were selected as the observation group, and 50 healthy people who underwent physical examination during the same period were selected as the control group. The venous blood samples of the subjects were collected, and the contents of serum tumor biomarkers, including carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigen-199 (CA-199), carbohydrate antigen-125 (CA-125) and carbohydrate antigen-153 (CA-153), were detected by chemiluminescence immunoassay. The test results were statistically analyzed.Results The levels of CEA, AFP, CA-199, CA-125 and CA-153 in the observation group were higher than those in the control group (P<0.05). The positive detection rates of CEA, AFP, CA-199, CA-125 and CA-153 in the observation group were higher than those in the control group (P<0.05). CEA, AFP, CA-199, CA-125 and CA-153 were detected in different malignant tumor diseases. Among them, CEA had the highest positive detection rate in colorectal cancer cases, AFP had the highest positive detection rate in liver cancer cases, CA-153 had the highest positive detection rate in breast cancer cases, CA-125 had the highest positive detection rate in ovarian cancer cases, and the positive detection rate was 100.00%.Conclusion Chemiluminescence immunoassay has a high detection effect on tumor biomarkers, and the effect of identification test is ideal.

参考文献/References:

[1]李锦霞,贺容容,屈圆.化学发光免疫法在原发性肝癌患者肿瘤标志物检验中的应用[J].中国肿瘤临床与康复,2021,28(2):207-209.[2]肖忠华,黄海兵.化学发光免疫法在肿瘤生物标志物检验中的应用[J].重庆医学,2015,44(28):4003-4004,4011.[3]张继田.观察化学发光免疫法在肿瘤生物标志物检验中的价值[J].中西医结合心血管病电子杂志,2020,8(27):105,107.[4]张艳波,宋秀燕.化学发光免疫法在肿瘤生物标志物检验中的应用[J].中国继续医学教育,2016,8(5):28-29.[5]李瑞.探讨肿瘤生物标志物检验中化学发光免疫法的临床价值[J].首都食品与医药,2020,27(9):120.[6]Cao JT,Zhang WS,Wang H,et al.A novel nitrogen and sulfur co-doped carbon dots-H2O2 chemiluminescence system for carcinoembryonic antigen detection using functional HRP-Au@Ag for signal amplification[J].Spectrochim Acta A Mol Biomol Spectrosc,2019,5(219):281-287.[7]杨晓芳,郭炜,王欣.肿瘤生物标志物检验中化学发光免疫法的应用探讨[J].临床检验杂志(电子版),2019,8(3):62-63.[8]孙巧梅,姜桂环.化学发光免疫法在肿瘤生物标志物检验中的应用价值分析[J].临床检验杂志(电子版),2018,7(3):549.[9]何继宏.肿瘤生物标志物检验中化学发光免疫法的应用价值[J].深圳中西医结合杂志,2018,28(9):61-63.[10]黄永攀.化学发光免疫法在肿瘤生物标志物检验中的应用[J].吉林医学,2018,39(2):271-272.[11]Chen Y,Chu W,Liu W,et al.Paper-based chemiluminescence immunodevice for the carcinoembryonic antigen by employing multi-enzyme carbon nanosphere signal enhancement[J].Microchimica Acta,2018,185(3):187.[12]赵继学,王静岩.观察化学发光免疫法在肿瘤生物标志物检验中的运用效果[J].中国继续医学教育,2017,9(1):66-67.[13]高振霞,朱立梅.化学发光免疫法在肿瘤生物标志物检验中的应用[J].中国农村卫生,2016(24):40.[14]成晨.肿瘤生物标志物检验的化学发光免疫法应用[J].中国卫生标准管理,2020,11(11):117-119.[15]高鹏飞,杨豪俊.不同肿瘤标志物联合检测对原发性肝癌的诊断效能分析[J].海南医学院学报,2019,25(11):858-861,866.[16]Nakagawa M,Karashima T,Kamada M,et al.Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-γ2 as a promising diagnostic tool of non-muscle invasive bladder cancer[J].Biomarker Research,2017,5(1):29.[17]吴丹,朱建奎,张艳,等.化学发光免疫法检验原发性肝癌肿瘤生物标志物的应用价值研究[J].实用癌症杂志,2019,34(6):1002-1004.[18]范艳佳,陈美红,颜林林.化学发光免疫法在肿瘤生物标志物检测中的应用价值[J].实用预防医学,2021,28(11):1397-1400.

相似文献/References:

[1]陈学敏,彭 琼.中性粒细胞与淋巴细胞比值联合癌胚抗原对结直肠癌早期诊断的研究[J].医学信息,2019,32(02):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
　CHEN Xue-min,PENG Qiong.Early Diagnosis of Colorectal Cancer by Neutrophil-lymphocyte Ratio Combined with Carcinoembryonic Antigen[J].Journal of Medical Information,2019,32(20):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
[2]展帮乐,阮建波,朱和玲,等.生殖器疱疹高危人群两种血清学检测方法阳性率的比较[J].医学信息,2019,32(17):178.[doi:10.3969/j.issn.1006-1959.2019.17.061]
　ZHAN Bang-le,RUAN Jian-bo,ZHU He-ling,et al.Comparison of Positive Rates of Two Serological Tests for High Risk Population of Genital Herpes[J].Journal of Medical Information,2019,32(20):178.[doi:10.3969/j.issn.1006-1959.2019.17.061]
[3]江 灵,王 华,王雨涵,等.血清学方法在检测抗[J].医学信息,2019,32(13):155.[doi:10.3969/j.issn.1006-1959.2019.13.049]
　JIANG Ling,WANG Hua,WANG Yu-han,et al.Application of Serological Detection Method in Anti-HIV[J].Journal of Medical Information,2019,32(20):155.[doi:10.3969/j.issn.1006-1959.2019.13.049]
[4]胡思芹,李运新,曾福英.血清AFP、CEA、CA199、CA724联合检测对消化道恶性肿瘤的诊断价值[J].医学信息,2020,33(15):170.[doi:10.3969/j.issn.1006-1959.2020.15.054]
　HU Si-qin,LI Yun-xin,ZENG Fu-ying.The Diagnostic Value of Combined Detection of Serum AFP,CEA,CA199,CA724 for Malignant Tumors of Digestive Tract[J].Journal of Medical Information,2020,33(20):170.[doi:10.3969/j.issn.1006-1959.2020.15.054]
[5]石少庆.甲磺酸阿帕替尼片治疗晚期非小细胞肺癌的临床效果[J].医学信息,2023,36(01):152.[doi:10.3969/j.issn.1006-1959.2023.01.032]
　SHI Shao-qing.Clinical Effect of Apatinib Mesylate Tablets in the Treatment of Advanced Non-small Cell Lung Cancer[J].Journal of Medical Information,2023,36(20):152.[doi:10.3969/j.issn.1006-1959.2023.01.032]
[6]宁 萍,王雪婷,李奋荣,等.基于EP9-A3文件对两仪器测定血清甲胎蛋白、癌胚抗原结果的可比性评价[J].医学信息,2024,37(05):138.[doi:10.3969/j.issn.1006-1959.2024.05.025]
　NING Ping,WANG Xue-ting,LI Fen-rong,et al.Comparability of the Results of Serum Alpha-fetoprotein and Carcinoembryonic Antigen Measured by the Two Instruments Based on the EP9-A3 Document[J].Journal of Medical Information,2024,37(20):138.[doi:10.3969/j.issn.1006-1959.2024.05.025]
[7]刘雨虹.血清AFP、CEA和CA199联合检测在丙肝相关肝硬化和肝癌鉴别诊断中的临床价值[J].医学信息,2024,37(17):139.[doi:10.3969/j.issn.1006-1959.2024.17.030]
　LIU Yu-hong.Clinical Value of Combined Detection of Serum AFP, CEA and CA199 in the Differential Diagnosisof Hepatitis C-related Cirrhosis and Liver Cancer[J].Journal of Medical Information,2024,37(20):139.[doi:10.3969/j.issn.1006-1959.2024.17.030]

更新日期/Last Update: 1900-01-01