[1]文 静.HBV感染患者血清25（OH）D3含量与HBV DNA载量的相关性[J].医学信息,2022,35(21):81-83，91.[doi:10.3969/j.issn.1006-1959.2022.21.018]
　WEN Jing.Correlation Between Serum 25(OH)D3 Content and HBV DNA Load in Patients with HBV Infection[J].Journal of Medical Information,2022,35(21):81-83，91.[doi:10.3969/j.issn.1006-1959.2022.21.018]
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HBV感染患者血清25（OH）D3含量与HBV DNA载量的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年21期
页码:
81-83，91
栏目:
论著
出版日期:
2022-11-01

文章信息/Info

Title:
Correlation Between Serum 25(OH)D3 Content and HBV DNA Load in Patients with HBV Infection
文章编号:
1006-1959（2022）21-0081-04
作者:
文 静
（空军军医大学西京医院检验科，陕西 西安 710032）
Author(s):
WEN Jing
(Department of Clinical Laboratory,Xijing Hospital of Air Force Medical University,Xi’an 710032,Shaanxi,China)
关键词:
乙型肝炎病毒; 血清25（OH）D3; HBV DNA载量
Keywords:
Hepatitis B virus; Serum 25(OH)D3;  HBV DNA load
分类号:
R446.5
DOI:
10.3969/j.issn.1006-1959.2022.21.018
文献标志码:
A
摘要:
目的 研究乙型肝炎病毒（HBV）感染患者血清25-羟维生素D3[25（OH）D3]含量与HBV DNA载量的相关性。方法 选取2020年6月-2021年6月我院诊治的92例HBV感染患者为观察组，并选取同期在我院体检健康者90例为对照组，均进行血清25（OH）D3含量与HBV DNA载量检测，比较两组血清25（OH）D3含量、不同临床期患者血清25（OH）D3含量和HBV DNA载量、不同血清25（OH）D3含量患者HBV DNA载量表达阴性率和不同水平HBV DNA载量阳性率比例，并采用血清25（OH）D3含量与HBV DNA载量的相关性。结果 观察组血清25（OH）D3水平低于对照组（P＜0.05）。慢性乙肝肝炎患者血清25（OH）D3含量均高于无症状携带、原发性肝细胞性肝癌、肝炎肝硬化患者（P＜0.05）；原发性肝细胞性肝癌患者HBV DNA载量高于无症状携带、慢性乙肝肝炎、肝炎肝硬化患者（P＜0.05）。血清25（OH）D3含量≥30 ng/ml患者HBV DNA载量阴性率高于血清25（OH）D3含量20~29.90 ng/ml、≤19.9 ng/ml患者，且HBV DNA载量＜103 IU/ml阳性率占比高于20~29.90 ng/ml和≤19.9 ng/ml组（P＜0.05）；HBV DNA载量103~105 IU/ml阳性率占比小于20~29.90 ng/ml和≤19.9 ng/ml患者，但20~29.90 ng/ml和≤19.9 ng/ml患者比较，差异无统计学意义（P＞0.05）；HBV DNA载量＞105 IU/ml阳性率占比低于20~29.90 ng/ml和≤19.9 ng/ml患者，且20~29.90 ng/ml患者低于≤19.9 ng/ml患者（P＜0.05）。Spearman相关性分析显示，HBV感染患者血清25（OH）D3含量与HBV DNA载量呈负相关（r=-0.429，P=0.015）。结论 HBV感染患者血清25（OH）D3含量较低，而不同临床分期患者血清25（OH）D3含量和HBV DNA载量存在差异，其中HBV DNA载量随病情发展逐渐升高，且血清25（OH）D3含量与HBV DNA载量呈负相关。
Abstract:
Objective To study the correlation between serum 25-hydroxyvitamin D3 [25(OH)D3] content and HBV DNA load in patients with hepatitis B virus (HBV) infection.Methods A total of 92 patients with HBV infection diagnosed and treated in our hospital from June 2020 to June 2021 were selected as the observation group, and 90 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Serum 25(OH)D3 content and HBV DNA load were detected. The serum 25(OH)D3 content, serum 25(OH)D3 content and HBV DNA load in patients with different clinical stages, the negative rate of HBV DNA load expression in patients with different serum 25(OH)D3 content and the positive rate of HBV DNA load at different levels were compared between the two groups. The correlation between serum 25(OH)D3 content and HBV DNA load was analyzed.Results The serum 25(OH)D3 level in the observation group was lower than that in the control group (P<0.05). The level of serum 25(OH)D3 in patients with chronic hepatitis B was higher than that in asymptomatic carriers, primary hepatocellular carcinoma and liver cirrhosis (P<0.05). The HBV DNA load in patients with primary hepatocellular carcinoma was higher than that in patients with asymptomatic carrier, chronic hepatitis B and hepatitis cirrhosis (P<0.05). The negative rate of HBV DNA load in patients with serum 25(OH)D3 content≥30 ng/ml was higher than that in patients with serum 25(OH)D3 content 20-29.90 ng/ml and ≤19.9 ng/ml, and the positive rate of HBV DNA load <103 IU/ml was higher than that in 20-29.90 ng/ml and ≤19.9 ng/ml groups (P<0.05); the positive rate of HBV DNA load 103-105 IU/ml was less than 20-29.90 ng/ml and ≤19.9 ng/ml, but there was no significant difference between 20-29.90 ng/ml and ≤ 19.9 ng/ml (P>0.05). The positive rate of HBV DNA load>105 IU/ml was lower than that of patients with 20-29.90 ng/ml and ≤19.9 ng/ml, and that of patients with 20-29.90 ng/ml was lower than that of patients with ≤19.9 ng/ml (P<0.05). Spearman correlation analysis showed that serum 25(OH)D3 content was negatively correlated with HBV DNA load in patients with HBV infection (r=-0.429, P=0.015).Conclusion The serum 25(OH)D3 content in patients with HBV infection is low, and there are differences in serum 25(OH)D3 content and HBV DNA load in patients with different clinical stages. The HBV DNA load gradually increases with the development of the disease, and the serum 25(OH)D3 content is negatively correlated with HBV DNA load.

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更新日期/Last Update: 1900-01-01