[1]张 伟,钱 玥,金 雪,等.SETDB2在甲状腺癌中的表达及临床意义[J].医学信息,2022,35(24):12-17.[doi:10.3969/j.issn.1006-1959.2022.24.003]
　ZHANG Wei,QIAN Yue,JIN Xue,et al.The Expression and Clinical Significance of SETDB2 in Thyroid Cancer[J].Journal of Medical Information,2022,35(24):12-17.[doi:10.3969/j.issn.1006-1959.2022.24.003]
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SETDB2在甲状腺癌中的表达及临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年24期
页码:
12-17
栏目:
生物信息学
出版日期:
2022-12-15

文章信息/Info

Title:
The Expression and Clinical Significance of SETDB2 in Thyroid Cancer
文章编号:
1006-1959（2022）24-0012-06
作者:
张 伟; 钱 玥; 金 雪; 等
（贵州护理职业技术学院基础医学部，贵州 贵阳 550000）
Author(s):
ZHANG Wei; QIAN Yue; JIN Xue; et al.
(Department of Basic Medicine,Guizhou Nursing Vocational College,Guiyang 550000,Guizhou,China)
关键词:
甲状腺癌; SETDB2; 肿瘤免疫浸润; 免疫治疗
Keywords:
Thyroid cancer; SETDB2; Tumor immune infiltration; Immunotherapy
分类号:
R392.12；R736.1
DOI:
10.3969/j.issn.1006-1959.2022.24.003
文献标志码:
A
摘要:
目的 利用TCGA数据库探讨SETDB2与甲状腺癌（THCA）临床特征之间的相关性。方法 在TCGA数据库下载510例甲状腺癌患者和58份癌旁对照组织样本的临床数据和RNA-seq结果，探究SETDB2在甲状腺癌患者肿瘤组织和健康对照组织中的表达；应用HPA和GEO数据库检索SETDB2基因的表达；采用UALCAN数据库分析SETDB2表达水平和甲状腺癌患者临床病理特征之间的关系；通过GEPIA数据库评估甲状腺癌患者无进展间隔期（PFI）与SETDB2表达水平的关系；使用ROC曲线下面积（AUC）评估SETDB2作为甲状腺癌患者分类的价值；利用 LinkedOmics 数据库分析甲状腺癌中与SETDB2共表达的基因及其富集分析；利用TIMER2.0在线分析免疫细胞浸润，评估SETDB2的表达水平对免疫治疗的反应。结果 甲状腺癌组织中SETDB2表达水平低于正常对照组（P＜0.05）；甲状腺癌患者中SETDB2的低表达与T期、淋巴结转移、肿瘤残余和肿瘤分期有关（P＜0.05）；ROC曲线显示，SETDB2在甲状腺癌分类中具有较高的诊断价值（AUC=0.898）；SETDB2表达降低与患者较差的PFI相关（P＜0.05）；SETDB2可能参与抗菌素的体液反应和细胞凋亡；SETDB2低表达与免疫细胞的浸润能力增强有关。结论 SETDB2表达降低与甲状腺癌患者预后较差和免疫细胞浸润增强相关，提示SETDB2可能可以作为甲状腺癌的预后生物标志物。
Abstract:
Objective To explore the correlation between SETDB2 and clinical features of thyroid cancer (THCA) using TCGA database.Methods The clinical data and RNA-seq results of 510 thyroid cancer patients and 58 adjacent control tissue samples were downloaded from the TCGA database to explore the expression of SETDB2 in tumor tissues of thyroid cancer patients and healthy control tissues. The expression of SETDB2 gene was retrieved by HPA and GEO databases. UALCAN database was used to analyze the relationship between SETDB2 expression level and clinicopathological features of thyroid cancer patients. The relationship between progression-free interval (PFI) and SETDB2 expression level in thyroid cancer patients was evaluated by GEPIA database. The area under the ROC curve (AUC) was used to evaluate the value of SETDB2 as a classification of thyroid cancer patients. The genes co-expressed with SETDB2 in thyroid cancer and their enrichment analysis were analyzed by LinkedOmics database. TIMER2.0 online analysis of immune cell infiltration was used to evaluate the response of SETDB2 expression level to immunotherapy.Results The expression level of SETDB2 in thyroid cancer tissues was lower than that in normal control group (P<0.05). The low expression of SETDB2 in thyroid cancer patients was related to T stage, lymph node metastasis, tumor residual and tumor stage (P<0.05). ROC curve showed that SETDB2 had high diagnostic value in thyroid cancer classification (AUC=0.898). The decreased expression of SETDB2 was associated with poor PFI (P<0.05). SETDB2 may be involved in the humoral response and apoptosis of antibiotics. The low expression of SETDB2 was related to the enhanced infiltration ability of immune cells.Conclusion The decreased expression of SETDB2 is associated with poor prognosis and enhanced immune cell infiltration in patients with thyroid cancer, suggesting that SETDB2 may be a prognostic biomarker for thyroid cancer.

参考文献/References:

[1]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.[2]Staniforth J,Erdirimanne S,Eslick GD.Thyroid carcinoma in Graves’ disease: A meta-analysis[J].Int J Surg,2016,27:118-125.[3]Nath MC,Erickson LA.Aggressive Variants of Papillary Thyroid Carcinoma: Hobnail, Tall Cell, Columnar, and Solid[J].Adv Anat Pathol,2018,25(3):172-179.[4]Lan X,Bao H,Ge X,et al.Genomic landscape of metastatic papillary thyroid carcinoma and novel biomarkers for predicting distant metastasis[J].Cancer Sci,2020,111(6):2163-2173.[5]孙黎明.分化型甲状腺癌腺外侵犯和预后水平的影响因素[J].中国卫生工程学,2022,21(3):424-426.[6]Coca-Pelaz A,Shah JP,Hernandez-Prera JC,et al.Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review[J].Adv Ther,2020,37(7):3112-3128.[7]Donaldson LB,Yan F,Morgan PF,et al.Hobnail variant of papillary thyroid carcinoma: a systematic review and meta-analysis[J].Endocrine,2021,72(1):27-39.[8]Na HH,Moon S,Kim KC.Knockout of SETDB1 gene using the CRISPR/cas-9 system increases migration and transforming activities via complex regulations of E-cadherin, beta-catenin, STAT3, and Akt[J].Biochem Biophys Res Commun,2020,533(3):486-492.[9]Pan D,Bao X,Hu M,et al.SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy[J].Cancer Res,2022,82(15):2748-2760.[10]Du TT,Xu PF,Dong ZW,et al.Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1[J].Dev Biol,2014,392(2):233-244.[11]桂慧慧,刘霞.基于多数据库分析MYH10在肾透明细胞癌中的表达与意义[J].医学信息,2022,35(10):20-25.[12]Ibrahimpasic T,Ghossein R,Shah JP,et al.Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects[J].Thyroid,2019,29(3):311-321.[13]Cipriani NA.The metamorphosis of papillary thyroid carcinoma[J].Histopathology,2022,81(2):168-170.[14]Sur ML,Gaga R,Lazar C,et al.Papillary thyroid carcinoma in children with Hashimoto’s thyroiditis-a review of the literature between 2000 and 2020[J].J Pediatr Endocrinol Metab,2020,33(12):1511-1517.[15]Ying L,Fei X,Jialun L,et al.SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of DeltaNp63alpha protein[J].Int J Biol Sci,2020,16(12):2180-2191.[16]Mu G,Chen F.Oncogenic Roles Of A Histone Methyltransferase SETDB2 In AML1-ETO Positive AML[J].Cancer Manag Res,2020,12:783-792.[17]Lin CH,Wong SH,Kurzer JH,et al.SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression[J].Cell Rep,2018,23(4):1166-1177.[18]Maghsoudloo M,Azimzadeh JS,Najafi A,et al.An efficient hybrid feature selection method to identify potential biomarkers in common chronic lung inflammatory diseases[J].Genomics,2020,112(5):3284-3293.[19]贾龙梅,殷香宝,曾磊,等.甲基转移酶SETDB2对肝癌侵袭迁移的影响及其机制研究[J].天津医药,2018,46(10):1039-1044.[20]Islam R,Liu X,Gebreselassie G,et al.Genome-wide association analysis reveals the genetic locus for high reproduction trait in Chinese Arbas Cashmere goat[J].Genes Genomics,2020,42(8):893-899.[21]Li YC,Wang GW,Xu SR,et al.The expression of histone methyltransferases and distribution of selected histone methylations in testes of yak and cattle-yak hybrid[J].Theriogenology,2020,144:164-173.[22]Ocklenburg S,Arning L,Gerding WM,et al.Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults[J].Mol Neurobiol,2016,53(9):6355-6361.[23]Cowman SJ,Koh MY.Revisiting the HIF switch in the tumor and its immune microenvironment[J].Trends Cancer,2022,8(1):28-42.[24]Wiede F,Lu KH,Du X,et al.PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity[J].Cancer Discov,2022,12(3):752-773.[25]Janes PW,Vail ME,Ernst M,et al.Eph Receptors in the Immunosuppressive Tumor Microenvironment[J].Cancer Res,2021,81(4):801-805.

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更新日期/Last Update: 1900-01-01