[1]刘晓丹,尚士梅,林先和.血sST2浓度联合MLR水平对冠心病患者MACE事件的预测价值[J].医学信息,2023,36(17):123-126,137.[doi:10.3969/j.issn.1006-1959.2023.17.024]
　LIU Xiao-dan,SHANG Shi-mei,LIN Xian-he.The Predictive Value of Serum sST2 Concentration Combined with MLR Level for MACE Events in Patients with Coronary Heart Disease[J].Journal of Medical Information,2023,36(17):123-126,137.[doi:10.3969/j.issn.1006-1959.2023.17.024]
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血sST2浓度联合MLR水平对冠心病患者MACE事件的预测价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年17期
页码:
123-126,137
栏目:
论著
出版日期:
2023-09-01

文章信息/Info

Title:
The Predictive Value of Serum sST2 Concentration Combined with MLR Level for MACE Events in Patients with Coronary Heart Disease
文章编号:
1006-1959（2023）17-0123-05
作者:
刘晓丹; 尚士梅; 林先和
（1.安徽医科大学第一附属医院心内科，安徽 合肥 230022；2.安徽医科大学研究生学院，安徽 合肥 230032）
Author(s):
LIU Xiao-dan; SHANG Shi-mei; LIN Xian-he
(1.Department of Cardiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China; 2.Graduate School of Anhui Medical University,Hefei 230032,Anhui,China)
关键词:
冠心病; 可溶性致瘤性抑制蛋白2; 单核细胞/淋巴细胞; 主要不良心血管事件
Keywords:
Coronary heart disease; Soluble suppression of tumorigenicity 2; Monocyte/lymphocyte ratio; Major adverse cardiovascular event
分类号:
R543.5
DOI:
10.3969/j.issn.1006-1959.2023.17.024
文献标志码:
A
摘要:
目的 探讨血可溶性致瘤性抑制蛋白2（sST2）浓度联合单核细胞/淋巴细胞比率（MLR）水平对冠心病患者主要不良心血管事件（MACE）的预测价值。方法 选取2021年3月-2022年2月就诊于安徽医科大学第一附属医院心血管内科且符合ACCF/AHA指南中冠心病诊断标准的121例患者，根据是否发生MACE事件发生分为MACE事件（+）组（n=39）和MACE事件（-）组（n=82）。采用单因素及多因素二元Logistic回归分析影响MACE事件发生的危险因素，采用受试者工作特征（ROC）曲线描述血sST2浓度联合MLR水平对MACE事件的预测价值。结果 两组性别、年龄、BMI、吸烟史、饮酒史、高血压史、糖尿病史、PCI病史、TC、TG、n-HDL、HDL-C、LDL-C、LPa比较，差异无统计学意义（P＞0.05）；两组NLR、MLR、BNP、LVEF、LVD、sST2比较，差异有统计学意义（P＜0.05）。多因素二元Logistic回归分析结果显示，sST2、MLR水平为发生MACE事件的影响因素（P＜0.05）。ROC曲线分析显示，sST2联合MLR预测MACE事件的AUC为0.817。结论 血清sST2联合MLR对冠心病患者MACE事件有一定的预测价值。
Abstract:
Objective To investigate the predictive value of soluble suppression of tumorigenicity 2 (sST2) combined with monocyte/lymphocyte ratio (MLR) level on major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD).Methods A total of 121 patients who were admitted to the Department of Cardiology, the First Affiliated Hospital of Anhui Medical University from March 2021 to February 2022 and met the diagnostic criteria of coronary heart disease in the ACCF/AHA guidelines were selected. According to the occurrence of MACE events, they were divided into MACE event (+) group (n=39) and MACE event (-) group (n=82). Univariate and multivariate binary Logistic regression analysis were used to analyze the risk factors affecting the occurrence of MACE events. The receiver operating characteristic (ROC) curve was used to describe the predictive value of blood sST2 concentration combined with MLR level for MACE events.Results There was no significant difference in gender, age, BMI, smoking history, drinking history, hypertension history, diabetes history, PCI history, TC, TG, n-HDL, HDL-C, LDL-C and LPa between the two groups (P>0.05), while there were significant differences in NLR, MLR, BNP, LVEF, LVD and sST2 between the two groups (P<0.05). Multivariate binary Logistic regression analysis showed that sST2 and MLR levels were the influencing factors of MACE events (P<0.05). ROC curve analysis showed that the AUC of sST2 combined with MLR in predicting MACE events was 0.817.Conclusion sST2 combined with MLR has a certain predictive value in patients with coronary heart disease.

参考文献/References:

[1]Zhang T,Xu C,Zhao R,et al.Diagnostic Value of sST2 in Cardiovascular Diseases: A Systematic Review and Meta-Analysis[J].Front Cardiovasc Med,2021,8:697837.[2]Dieplinger B,Mueller T.Soluble ST2 in heart failure[J].Clin Chim Acta,2015,443:57-70.[3]Yancy CW,Jessup M,Bozkurt B,et al.2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines[J].J Am Coll Cardiol,2013,62(16):e147-239.[4]Chen H,Li M,Liu L,et al.Monocyte/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients with non-ST-elevation myocardial infarction[J].Medicine (Baltimore),2019,98(26):e16267.[5]Kim KW,Ivanov S,Williams JW.Monocyte Recruitment,Specification,and Function in Atherosclerosis[J].Cells,2020,10(1):15.[6]Munjal A,Khandia R.Atherosclerosis:orchestrating cells and biomolecules involved in its activation and inhibition[J].Adv Protein Chem Struct Biol,2020,120:85-122.[7]Franey EG,Kritz-Silverstein D,Richard EL,et al.Association of Race and Major Adverse Cardiac Events (MACE):The Atherosclerosis Risk in Communities (ARIC) Cohort[J].J Aging Res,2020,2020:7417242.[8]Mo J,Chen Z,Xu J,et al.The impact of the cumulative burden of LDL-c and hs-CRP on cardiovascular risk:a prospective,population-based study[J].Aging (Albany NY),2020,12(12):11990-12001.[9]徐小燕,宋子凯,张洋,等.急性心肌梗死急诊行PCI术后患者血清氨基末端脑钠肽前体和脂蛋白a水平变化及其临床意义[J].吉林大学学报(医学版),2020,46(1):132-137.[10]Wang R,Wang X,Zhang E,et al.Correlation of plasma galectin-3 and plasma lipoprotein-associated phospholipase A2 with the severity and prognosis of coronary artery disease[J].Am J Transl Res,2021,13(8):8997-9004.[11]Tominaga S.A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor[J].FEBS Lett,1989,258(2):301-304.[12]Schmitz J,Owyang A,Oldham E,et al.IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J].Immunity,2005,23(5):479-490.[13]Pascual-Figal DA,Lax A,Perez-Martinez MT,et al.Clinical relevance of sST2 in cardiac diseases[J].Clin Chem Lab Med,2016,54(1):29-35.[14]Dudek M,Ka?覥uｚna-Oleksy M,Migaj J,et al.Clinical value of soluble ST2 in cardiology[J].Adv Clin Exp Med,2020,29(10):1205-1210.[15]Villacorta H,Maisel AS.Soluble ST2 Testing:A Promising Biomarker in the Management of Heart Failure[J].Arq Bras Cardiol,2016,106(2):145-152.[16]Avci A,Somuncu MU,Can M,et al.Could sST2 Predict Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction?[J].Int J Gen Med,2020,13:1297-1304.[17]Dieplinger B,Egger M,Haltmayer M,et al.Increased soluble ST2 predicts long-term mortality in patients with stable coronary artery disease:results from the Ludwigshafen risk and cardiovascular health study[J].Clin Chem,2014,60(3):530-540.[18]Ley K,Miller YI,Hedrick CC.Monocyte and macrophage dynamics during atherogenesis[J].Arterioscler Thromb Vasc Biol,2011,31(7):1506-1516.[19]王熙智,秦海燕.单核细胞/高密度脂蛋白比值、单核细胞/淋巴细胞比值与非ST段抬高型心肌梗死及冠状动脉病变严重程度的关系研究[J].实用心脑肺血管病杂志,2018,26(10):18-23.[20]Potteaux S,Gautier EL,Hutchison SB,et al.Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression[J].J Clin Invest,2011,121(5):2025-2036.[21]Wen Y,Zhan X,Wang N,et al.Monocyte/lymphocyte ratio and cardiovascular disease mortality in peritoneal Dialysis patients[J].Mediat Inflamm,2020,2020:9852507.[22]Gijsberts CM,Ellenbroek G,Ten Begr MJ,et al.Effect of Monocyte-to-Lymphocyte Ratio on Heart Failure Characteristics and Hospitalizations in a Coronary Angiography Cohort[J].Am J Cardiol,2017,120(6):911-916.[23]Ahmed A,Koma MK.Interleukin-33 triggers B1 cell expansion and its release of monocyte/macrophage chemoattractants and growth factors[J].Scand J Immunol,2015,82(2):118-124.[24]Matilla L,Ibarrola J,Arrieta V,et al.Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts:an in vitro and in vivo study in aortic stenosis[J].Clin Sci (Lond),2019,133(14):1537-1548.[25]Bevers MB,Wolcott Z,Bache S,et al.Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage[J].Ann Neurol,2019,86(3):384-394.

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更新日期/Last Update: 1900-01-01