[1]闫静静,韩 怡.幽门螺旋杆菌感染与非酒精性脂肪性肝病的相关性研究[J].医学信息,2023,36(18):114-118.[doi:10.3969/j.issn.1006-1959.2023.18.021]
　YAN Jing-jing,HAN Yi.Correlation Analysis Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease[J].Journal of Medical Information,2023,36(18):114-118.[doi:10.3969/j.issn.1006-1959.2023.18.021]
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幽门螺旋杆菌感染与非酒精性脂肪性肝病的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年18期
页码:
114-118
栏目:
论著
出版日期:
2023-09-15

文章信息/Info

Title:
Correlation Analysis Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease
文章编号:
1006-1959（2023）18-0114-05
作者:
闫静静; 韩 怡
（安徽医科大学附属阜阳医院消化内科，安徽 阜阳 236001）
Author(s):
YAN Jing-jing; HAN Yi
(Department of Gastroenterology,Fuyang Hospital Affiliated to Anhui Medical University,Fuyang 236001,Anhui,China)
关键词:
幽门螺旋杆菌; 非酒精性脂肪性肝病; 脂肪肝
Keywords:
Helicobacter pylori infection; Nonalcoholic fatty liver disease; Fatty liver
分类号:
R575
DOI:
10.3969/j.issn.1006-1959.2023.18.021
文献标志码:
A
摘要:
目的 研究幽门螺旋杆菌（Hp）感染与非酒精性脂肪性肝病（NAFLD）的相关性。方法 选取2017年7月-2021年2月在安徽医科大学附属阜阳医院体检中心进行健康体检的2270例体检者，根据13C-尿素呼气试验检测结果确定Hp感染率情况，并根据有无脂肪肝将体检者分为NAFLD组和非NAFLD组，比较两组人口统计学特征、人体测量指标及血糖血脂、肝酶等指标，分析Hp感染与NAFLD的相关性。结果 2270例健康体检者Hp感染率为44.32%，不同性别、年龄的健康体检者Hp感染率比较，差异无统计学意义（P＞0.05）；2270例健康体检者NAFLD的患病率为33.08%，其中男性患病率高于女性（39.67% vs. 17.58%），差异有统计学意义（P＜0.05）；NAFLD组Hp感染率、体重、BMI、FPG、TG、LDL、TC、UR、HB、ALT、AST、ALP、GGT、SBP、DBP高于非NAFLD组，HDL低于非NAFLD组，差异有统计学意义（P＜0.05）；在调整潜在混杂因素后，Hp感染与NAFLD之间无相关性（OR=1.131，95%CI：0.843~1.516，P=0.412）。结论 在健康体检人群中，Hp感染与NAFLD的发生无相关性。
Abstract:
Objective To investigate the correlation between helicobacter pylori infection and nonalcoholic fatty liver disease.Methods A total of 2270 physical examinees were included in the physical examination center of Fuyang Hospital Affiliated to Anhui Medical University from July 2017 to February 2021. Hp infection rate was determined according to the results of 13C urea breath test, and the physical examinees were divided into NAFLD group and non-NAFLD group according to the presence or absence of fatty liver. The demographic characteristics, anthropometric indexes, blood glucose, blood lipid and liver enzymes were compared between the two groups, and the correlation between Hp infection and NAFLD was analyzed.Results Among 2270 physical examinees, Hp infection rate was 44.32%. There was no significant difference in Hp infection rate among physical examinees of different genders and ages (P>0.05). The prevalence of NAFLD in 2270 physical examinees was 33.08%. The prevalence of NAFLD in males was higher than that in females (39.67% vs 17.58%), and the difference was statistically significant (P<0.05). Hp infection rate, body weight, BMI, FPG, TG, LDL, TC, UR, HB, ALT, AST, ALP, GGT, SBP and DBP in NAFLD group were higher than those in non-NAFLD group, and HDL was lower than that in non-NAFLD group (P<0.05). After adjusting for potential confounding factors, there was no correlation between Hp infection and NAFLD (OR=1.131,95%CI:0.843-1.516,P=0.412).Conclusion The Hp infection is not associated with NAFLD in the health examination population.

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更新日期/Last Update: 1900-01-01