[1]孟 华,苏馨雅,陆雯雯,等.CHA2DS2-VASc评分联合生物标志物对非瓣膜性心房颤动并发脑卒中诊断价值的系统综述[J].医学信息,2023,36(19):179-184.[doi:10.3969/j.issn.1006-1959.2023.19.041]
　MENG Hua,SU Xin-ya,LU Wen-wen,et al.A Systematic Review of the Diagnostic Value of CHA2DS2-VASc Score Combined with Biomarkers for Non-valvular Atrial Fibrillation Complicated by Stroke[J].Journal of Medical Information,2023,36(19):179-184.[doi:10.3969/j.issn.1006-1959.2023.19.041]
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CHA2DS2-VASc评分联合生物标志物对非瓣膜性心房颤动并发脑卒中诊断价值的系统综述()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年19期
页码:
179-184
栏目:
综述
出版日期:
2023-10-01

文章信息/Info

Title:
A Systematic Review of the Diagnostic Value of CHA2DS2-VASc Score Combined with Biomarkers for Non-valvular Atrial Fibrillation Complicated by Stroke
文章编号:
1006-1959（2023）19-0179-06
作者:
孟 华; 苏馨雅; 陆雯雯; 等
（1.宁夏医科大学公共卫生与管理学院，宁夏 银川 750004；2.宁夏环境因素与慢性病控制重点实验室，宁夏 银川 750004；3.宁夏回族自治区人民医院病案统计科，宁夏 银川 750002）
Author(s):
MENG Hua; SU Xin-ya; LU Wen-wen; et al.
(1.School of Public Health and Management,Ningxia Medical University,Yinchuan 750004,Ningxia,China;2.Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control,Yinchuan 750004, Ningxia,China;3.Department of Medical Record Statistics,People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,Ningxia,China)
关键词:
非瓣膜性心房颤动; 脑卒中; CHA2DS2-VASc评分; 生物标志物
Keywords:
Non-valvular atrial fibrillation; Stroke; CHA2DS2-VASc score; Biomarkers
分类号:
R743.33
DOI:
10.3969/j.issn.1006-1959.2023.19.041
文献标志码:
A
摘要:
目的 评价CHA2DS2-VASc评分联合生物标志物对我国人群非瓣膜性心房颤动（NVAF）患者并发脑卒中的诊断价值。方法 在CNKI、VIP、WanFangdata、CBM、PubMed、Cochrane Library、Embase数据库进行全面检索，检索时限为各数据库的收录起始年至2022年4月1日。使用EndNote 20进行文献管理，Excel 2016进行数据整理，并对收集的资料采用定性方法进行汇总。结果 最终纳入文献20篇，其中中文17篇，英文3篇，总样本量为9968例；队列研究8篇，病例对照研究12篇。纳入研究中CHA2DS2-VASc评分联合LDL-C/HDL-C、sST2、NLR、Lp-PLA2、Gal-3、UA、CRP、NT-proBNT的 ROC曲线下面积均高于单独CHA2DS2-VASC评分；联合MPV、D-D、E、E/e’未提高诊断价值，且联合LAD的诊断价值存在争议。结论 对于CHA2DS2-VASc评分联合生物标志物改善NVAF患者发生脑卒中的诊断价值仍需更多研究证实。
Abstract:
Objective To comprehensive evaluation of the diagnostic value of CHA2DS2-VASc score combined with biomarkers for the non-valvular atrial fibrillation (NVAF) patients with stroke in a Chinese population.Methods A comprehensive search was conducted in CNKI, VIP, WanFangdata, CBM, PubMed, Cochrane Library, and Embase databases with the search time frame of the inclusion start year of each database to April 1, 2022. EndNote 20 was used for literature management, Excel 2016 was used for data collation, and the collected data were summarized by qualitative methods.Results A total of 20 articles were finally included with qualified criteria, including 17 articles in Chinese and 3 articles in English. The study dates ranged from December 2010 to March 31, 2021, with a total sample size of 9968 individuals. There were 8 cohort studies and 12 case-control studies. The area under the ROC curve of CHA2DS2-VASc score combined with LDL-C/HDL-C, sST2, NLR, Lp-PLA2, Gal-3, UA, CRP, and NT-proBNT was higher than that of CHA2DS2-VASC score alone in the included studies; the combination of MPV, D-D, E, and E/e’ did not improve the diagnostic value; the diagnostic value of combined LAD was controversial.Conclusion More studies are needed to confirm the diagnostic value of the CHA2DS2-VASc score combined with biomarkers to improve the diagnosis of stroke in patients with NVAF.

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更新日期/Last Update: 1900-01-01