[1]余呈丽,李瑞娟.无偿献血人群血液筛查后乙型肝炎病毒传播的残余风险评估[J].医学信息,2024,37(13):49-51,55.[doi:10.3969/j.issn.1006-1959.2024.13.009]
　Residual Risk Assessment of Hepatitis B Virus Transmission After Blood Screening in Voluntary Blood Donors.Residual Risk Assessment of Hepatitis B Virus Transmission After Blood Screening in Voluntary Blood Donors[J].Journal of Medical Information,2024,37(13):49-51,55.[doi:10.3969/j.issn.1006-1959.2024.13.009]
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无偿献血人群血液筛查后乙型肝炎病毒传播的残余风险评估()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
49-51,55
栏目:
公共卫生信息学
出版日期:
2024-07-01

文章信息/Info

Title:
Residual Risk Assessment of Hepatitis B Virus Transmission After Blood Screening in Voluntary Blood Donors
文章编号:
1006-1959（2024）13-0049-04
作者:
余呈丽; 李瑞娟
（曲靖市中心血站，云南 曲靖 655000）
Author(s):
Residual Risk Assessment of Hepatitis B Virus Transmission After Blood Screening in Voluntary Blood Donors
(Qujing City Center Blood Center,Qujing 655000,Yunnan,China)
关键词:
无偿献血; 乙型肝炎病毒;  HBsAg;  HBV DNA; 残余风险
Keywords:
Voluntary blood donors; Hepatitis B virus; HBsAg; HBV DNA; Residual risk
分类号:
R457.1；R512.6+2
DOI:
10.3969/j.issn.1006-1959.2024.13.009
文献标志码:
A
摘要:
目的 初步评估曲靖地区无偿献血人群血液筛查后乙型肝炎病毒传播的残余风险度，评价现行筛查模式，对下一步血液筛查工作的改进提供数据基础。方法 统计2020年1月1日-2022年12月31日曲靖市中心血站无偿献血者乙型肝炎病毒表面抗原（HBsAg）以及HBV DNA的筛查数据，采用发病率-窗口期比率数学模型（yield/WP ratio model）分别评估初次献血者及重复献血乙型肝炎病毒传播的残余风险。结果 2020-2022年，曲靖市中心血站共对173 084人次进行乙型肝炎筛查，其中初次献血者79 073人次，重复献血者94 011人次。ELISA检测HBsAg阳性340人次（初次献血者阳性273人次，重复献血者阳性67人次），核酸检测HBV DNA单阳68人次（初次献血者阳性41人次，重复献血者阳性27人次）。初次献血者HBsAg残余风险为10.21/10万人次，重复献血者HBsAg残余风险为3.4/10万人次；初次献血者HBV DNA残余风险为2.04/10万人次，重复献血者HBV DNA残余风险为0.68/10万人次。结论 曲靖地区无偿献血人群中重复献血者的乙型肝炎病毒传播残余风险低于初次献血者，增加一次核酸检测能够明显降低乙型肝炎病毒传播的残余风险，对保障血液安全，预防输血感染乙型肝炎病毒具有重要意义。现行筛查模式下，曲靖地区无偿献血人群乙型肝炎病毒传播残余风险较低，处于安全水平。
Abstract:
Objective To preliminarily evaluate the residual risk of hepatitis B virus transmission after blood screening among voluntary blood donors in Qujing area, evaluate the current screening model, and provide data basis for the improvement of blood screening work in the next step.Methods The screening data of hepatitis B virus surface antigen (HBsAg) and HBV DNA in voluntary blood donors in Qujing Central Blood Station from January 1, 2020 to December 31, 2022 were collected. The yield/WP ratio model was used to evaluate the residual risk of hepatitis B virus transmission in primary blood donors and repeated blood donors.Results From 2020 to 2022, a total of 173 084 people were screened for hepatitis B in Qujing Central Blood Station, including 79 073 initial blood donors and 94 011 repeated blood donors. There were 340 HBsAg positive cases detected by ELISA (273 positive cases in initial blood donors and 67 positive cases in repeated blood donors), and 68 HBV DNA positive cases detected by nucleic acid test (41 positive cases in initial blood donors and 27 positive cases in repeated blood donors). The residual risk of HBsAg in initial blood donors was 10.21/100 000, and the residual risk of HBsAg in repeated blood donors was 3.4/100 000. The residual risk of HBV DNA in first-time blood donors was 2.04/100 000, and the residual risk of HBV DNA in repeated blood donors was 0.68/100 000.Conclusion The residual risk of hepatitis B virus transmission in repeated blood donors in Qujing area is lower than that in first-time blood donors. Increasing one nucleic acid test can significantly reduce the residual risk of hepatitis B virus transmission, which is of great significance to ensure blood safety and prevent transfusion infection with hepatitis B virus. Under the current screening mode, the residual risk of hepatitis B virus transmission among voluntary blood donors in Qujing area is low and at a safe level.

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更新日期/Last Update: 1900-01-01