[1]陈菊花.左氧氟沙星与氨溴索联合治疗慢性阻塞性肺疾病合并肺部感染患者的疗效及安全性[J].医学信息,2024,37(24):85-88.[doi:10.3969/j.issn.1006-1959.2024.24.023]
　CHEN Juhua.Efficacy and Safety of Levofloxacin Combined with Ambroxol in the Treatment of Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Infection[J].Journal of Medical Information,2024,37(24):85-88.[doi:10.3969/j.issn.1006-1959.2024.24.023]
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左氧氟沙星与氨溴索联合治疗慢性阻塞性肺疾病合并肺部感染患者的疗效及安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年24期
页码:
85-88
栏目:
论著
出版日期:
2024-12-15

文章信息/Info

Title:
Efficacy and Safety of Levofloxacin Combined with Ambroxol in the Treatment of Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Infection
文章编号:
1006-1959（2024）24-0085-04
作者:
陈菊花
宜黄县中医院内科，江西 宜黄 344400
Author(s):
CHEN Juhua
Department of Internal Medicine,Yihuang County Hospital of Traditional Chinese Medicine,Yihuang 344400,Jiangxi,China
关键词:
左氧氟沙星; 氨溴索; 慢性阻塞性肺疾病; 肺部感染; 肺功能
Keywords:
Levofloxacin; Ambroxol; Chronic obstructive pulmonary disease; Pulmonary infection; Lung function
分类号:
R563
DOI:
10.3969/j.issn.1006-1959.2024.24.023
摘要:
目的 探讨左氧氟沙星与氨溴索联合治疗慢性阻塞性肺疾病（COPD）合并肺部感染患者的疗效及安全性。方法 按随机数字表法将宜黄县中医院2021年1月-2023年9月收治的58例COPD合并肺部感染患者分为对照组和研究组，各29例。对照组使用左氧氟沙星治疗，研究组使用左氧氟沙星与氨溴索联合治疗。比较两组临床治疗总有效率、炎症因子水平、血气指标水平、肺功能、不良反应发生率。结果 与对照组临床治疗总有效率（68.97%）比较，研究组临床治疗总有效率（96.44%）更高（P＜0.05）；与对照组比较，研究组治疗后PCT、IL-6、TNF-α、PaCO2更低，SpO2、PaO2、MVV、FVC、FEV1、FEV1/FVC更高（P＜0.05）；与对照组不良反应发生率（24.14%）比较，研究组不良反应发生率更低（3.45%）（P＜0.05）。结论 左氧氟沙星和氨溴索联合治疗可提升COPD合并肺部感染患者临床效果，降低气道炎症反应和血气指标水平，提高患者肺功能，且安全可靠。
Abstract:
Objective To investigate the efficacy and safety of levofloxacin combined with ambroxol in the treatment of patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary infection.Methods According to the random number table method, 58 patients with COPD complicated with pulmonary infection admitted to Yihuang County Hospital of Traditional Chinese Medicine from January 2021 to September 2023 were divided into control group and study group, with 29 patients in each group. The control group was treated with levofloxacin, and the study group was treated with levofloxacin combined with ambroxol. The total effective rate of clinical treatment, inflammatory factor level, blood gas index level, lung function and incidence of adverse reactions were compared between the two groups.Results Compared with the total effective rate of clinical treatment in the control group (68.97%), the total effective rate of clinical treatment in the study group (96.44%) was higher (P<0.05). Compared with the control group, PCT, IL-6, TNF-α, PaCO2 were lower, SpO2, PaO2, MVV, FVC, FEV1, FEV1/FVC were higher in the study group after treatment (P<0.05). Compared with the incidence of adverse reactions in the control group (24.14%), the incidence of adverse reactions in the study group was lower (3.45%) (P<0.05).Conclusion The combination of levofloxacin and ambroxol can improve the clinical effect of COPD patients with pulmonary infection, reduce the level of airway inflammation and blood gas index, and improve the lung function of patients, which is safe and reliable.

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更新日期/Last Update: 1900-01-01