[1]王 彧,王奕潇,杜美志,等.基于孟德尔随机化方法研究睡眠时长与结直肠癌发病风险的因果关联[J].医学信息,2025,38(04):16-20.[doi:10.3969/j.issn.1006-1959.2025.04.003]
 WANG Yu,WANG Yixiao,DU Meizhi,et al.The Causal Association Between Sleep Duration and the Risk of Colorectal Cancer Based on Mendelian Randomization Method[J].Journal of Medical Information,2025,38(04):16-20.[doi:10.3969/j.issn.1006-1959.2025.04.003]
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基于孟德尔随机化方法研究睡眠时长与结直肠癌发病风险的因果关联()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年04期
页码:
16-20
栏目:
临床信息学
出版日期:
2025-02-15

文章信息/Info

Title:
The Causal Association Between Sleep Duration and the Risk of Colorectal Cancer Based on Mendelian Randomization Method
文章编号:
1006-1959(2025)04-0016-05
作者:
王 彧1王奕潇1杜美志1孙枫雅1戴琳娜1刘芳睿1韦远奇2朱 云1
天津医科大学公共卫生学院1,生物医学工程与技术学院2,天津 300070
Author(s):
WANG Yu1 WANG Yixiao1 DU Meizhi1 SUN Fengya1 DAI Linna1 LIU Fangrui1 WEI Yuanqi2 ZHU Yun1
School of Public Health1, School of Biomedical Engineering and Technology2, Tianjin Medical University, Tianjin 300070, China
关键词:
结直肠癌睡眠时长工具变量因果关联孟德尔随机化
Keywords:
Colorectal cancer Sleep duration Instrumental variables Causal relationship Mendelian randomization
分类号:
R735
DOI:
10.3969/j.issn.1006-1959.2025.04.003
文献标志码:
A
摘要:
目的 通过两样本孟德尔随机化设计,探讨睡眠时长与结直肠癌发病风险之间的关联。方法 在IEU OpenGWAS project网站数据库中筛选并提取睡眠时长与结直肠癌发病风险的相关全基因组关联分析(GWAS)数据,其中睡眠时长的GWAS数据来源于460 099例欧洲人群荟萃分析数据,包括9 851 867个单核苷酸多态性(SNP)位点;结直肠癌的GWAS数据包括218 792例欧洲人群荟萃分析数据(结直肠癌3022例,对照组215 770例),共有16 380 466个SNP位点。采用逆方差加权(IVW)评估遗传学预测的不同睡眠时长与结直肠癌发生风险的关系,异质性检验和MR-Egger回归和逐个剔除实验进行敏感性分析,以评估工具变量的多效性。结果 IVW法结果显示,遗传学预测的睡眠时长与结直肠癌发病风险呈负相关(OR=0.494,95%CI:0.264~0.924);MR-Egger回归提示上述因果关联未受到水平多效性影响。结论 睡眠时长是结直肠癌的保护因素,随着睡眠时长的增加,结直肠癌发病风险降低。
Abstract:
Objective To explore the association between sleep duration and the risk of colorectal cancer by two-sample Mendelian randomization design. Methods Genome-wide association study (GWAS) data related to sleep duration and the risk of colorectal cancer were screened and extracted from the IEU OpenGWAS project website database. The GWAS data of sleep duration were derived from the meta-analysis data of 460 099 European populations, including 9 851 867 single nucleotide polymorphism (SNP) loci. The GWAS data of colorectal cancer included 218792 European population meta-analysis data (3022 cases of colorectal cancer and 215 770 cases of control group), with a total of 16 380 466 SNP loci. Inverse variance weighting (IVW) was used to evaluate the relationship between different sleep durations predicted by genetics and the risk of colorectal cancer. Heterogeneity test and MR-Egger regression and one-by-one rejection experiments were used for sensitivity analysis to evaluate the pleiotropy of instrumental variables. Results The results of IVW method showed that sleep duration predicted by genetics was negatively correlated with the risk of colorectal cancer (OR=0.494, 95%CI: 0.264-0.924). MR-Egger regression suggested that the above causal associations were not affected by level pleiotropy. Conclusion Sleep duration is a protective factor for colorectal cancer. With the increase of sleep duration, the risk of colorectal cancer decreases.

参考文献/References:

[1]Papantoniou K,Casta?觡o-Vinyals G,Espinosa A,et al.Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study[J].Sci Rep,2021,11(1):11822.[2]Thompson CL,Larkin EK,Patel S,et al.Short duration of sleep increases risk of colorectal adenoma[J].Cancer,2011,117(4):841-847.[3]Lin CL,Liu TC,Wang YN,et al.The Association Between Sleep Disorders and the Risk of Colorectal Cancer in Patients: A Population-based Nested Case-Control Study[J].In Vivo,2019,33(2):573-579.[4]Lin Y,Peng Y,Liang B,et al.Associations of dinner-to-bed time,post-dinner walk and sleep duration with colorectal cancer: A case-control study[J].Medicine (Baltimore),2018,97(34):e12038.[5]Wang G,Wang JJ,Lin CH,et al.Association of sleep duration,sleep apnea,and shift work with risk of colorectal neoplasms: a systematic review and meta-analysis[J].J Gastrointest Oncol,2022,13(4):1805-1817.[6]Papadimitriou N,Dimou N,Tsilidis KK,et al.Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis[J].Nat Commun,2020,11(1):597.[7]Morales Berstein F,McCartney DL,Lu AT,et al.Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study[J].Elife,2022,11:e75374.[8]Boehm FJ,Zhou X.Statistical methods for Mendelian randomization in genome-wide association studies: A review[J].Comput Struct Biotechnol J,2022,20:2338-2351.[9]Sekula P,Del Greco MF,Pattaro C,et al.Mendelian Randomization as an Approach to Assess Causality Using Observational Data[J].J Am Soc Nephrol,2016,27(11):3253-3265.[10]Bycroft C,Freeman C,Petkova D,et al.The UK Biobank resource with deep phenotyping and genomic data[J].Nature,2018,562(7726):203-209.[11]Kurki MI,Karjalainen J,Palta P,et al.FinnGen: Unique genetic insights from combining isolated population and national health register data[EB/OL].(2022-03-03)[2023-11-01].https://www.medrxiv.org/content/10.1101/2022.03.03.22271360v1.[12]Wu F,Huang Y,Hu J,et al.Mendelian randomization study of inflammatory bowel disease and bone mineral density[J].BMC Med,2020,18(1):312.[13]Lin Z,Deng Y,Pan W.Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model[J].PLoS Genet,2021,17(11):e1009922.[14]Baiocchi M,Cheng J,Small DS.Instrumental variable methods for causal inference[J].Stat Med,2014,33(13):2297-2340.[15]Burgess S,Butterworth A,Thompson SG.Mendelian randomization analysis with multiple genetic variants using summarized data[J].Genet Epidemiol,2013,37(7):658-665.[16]Wootton RE,Lawn RB,Millard LAC,et al.Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study[J].BMJ,2018,362:k3788.[17]Hartwig FP,Davey Smith G,Bowden J.Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption[J].Int J Epidemiol,2017,46(6):1985-1998.[18]Bowden J,Davey Smith G,Haycock PC,et al.Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator[J].Genet Epidemiol,2016,40(4):304-314.[19]Hwang LD,Lawlor DA,Freathy RM,et al.Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight[J].Int J Epidemiol,2019,48(5):1457-1467.[20]Greco MF,Minelli C,Sheehan NA,et al.Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome[J].Stat Med,2015,34(21):2926-2940.[21]Pan Y,Wang Y,Wang Y.Investigation of Causal Effect of Atrial Fibrillation on Alzheimer Disease: A Mendelian Randomization Study[J].J Am Heart Assoc,2020,9(2):e014889.[22]Chen J,Chen N,Huang T,et al.Sleep pattern,healthy lifestyle and colorectal cancer incidence[J].Sci Rep,2022,12(1):18317.[23]Zhang X,Giovannucci EL,Wu K,et al.Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women[J].Sleep,2013,36(5):681-688.[24]Ali T,Choe J,Awab A,et al.Sleep,immunity and inflammation in gastrointestinal disorders[J].World J Gastroenterol,2013,19(48):9231-9239.[25]Ranjbaran Z,Keefer L,Stepanski E,et al.The relevance of sleep abnormalities to chronic inflammatory conditions[J].Inflamm Res,2007,56(2):51-57.[26]Schernhammer ES,Laden F,Speizer FE,et al.Night-shift work and risk of colorectal cancer in the nurses’ health study[J].J Natl Cancer Inst,2003,95(11):825-828.[27]Nock NL,Li L,Larkin EK,et al.Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures[J].Sleep,2009,32(5):615-622.[28]Li X,Huang D,Liu F,et al.Sleep Characteristics and Cancer-Related Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies[J].J Clin Med,2022,11(24):7289. [29]Hurley S,Goldberg D,Bernstein L,et al.Sleep duration and cancer risk in women[J].Cancer Causes Control,2015,26(7):1037-1045.[30]Rychter AM,Lykowska-Szuber L,Zawada A,et al.Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?[J].J Clin Med,2023,12(7):2451.[31]Seo JY,Jin EH,Chung GE,et al.The risk of colorectal cancer according to obesity status at four-year intervals: a nationwide population-based cohort study[J].Sci Rep,2023,13(1):8928.[32]Vijayalaxmi,Thomas CR Jr,Reiter RJ,et al.Melatonin: from basic research to cancer treatment clinics[J].J Clin Oncol,2002,20(10):2575-2601.[33]Burgess S,Thompson SG.Interpreting findings from Mendelian randomization using the MR-Egger method[J].Eur J Epidemiol,2017,32(5):377-389.[34]Bowden J,Davey Smith G,Burgess S.Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression[J].Int J Epidemiol,2015,44(2):512-525.

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更新日期/Last Update: 1900-01-01