[1]陈 娟,刘俊敏,曾媛梅.替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死患者临床疗效及心电图变化的影响[J].医学信息,2025,38(12):86-90.[doi:10.3969/j.issn.1006-1959.2025.12.017]
　CHEN Juan,LIU Junmin,ZENG Yuanmei.Effects of Ticagrelor and Clopidogrel on Clinical Efficacy and Electrocardiogram Changes in Patients with Acute ST-segment Elevation Myocardial Infarction[J].Journal of Medical Information,2025,38(12):86-90.[doi:10.3969/j.issn.1006-1959.2025.12.017]
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替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死患者临床疗效及心电图变化的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年12期
页码:
86-90
栏目:
论著
出版日期:
2025-06-15

文章信息/Info

Title:
Effects of Ticagrelor and Clopidogrel on Clinical Efficacy and Electrocardiogram Changes in Patients with Acute ST-segment Elevation Myocardial Infarction
文章编号:
1006-1959（2025）12-0086-05
作者:
陈 娟1; 刘俊敏2; 曾媛梅1
宁都县人民医院心脑电图室1，心血管内科2，江西 宁都 362800
Author(s):
CHEN Juan1;  LIU Junmin2;  ZENG Yuanmei1
Cardio-cerebral Electroencephalogram Room1, Department of Cardiovascular Medicine2, Ningdu County People’s Hospital, Ningdu 362800, Jiangxi, China
关键词:
替格瑞洛; 氯吡格雷; 急性ST段抬高型心肌梗死; 心电图
Keywords:
Ticagrelor;  Clopidogrel;  Acute ST elevation myocardial infarction;  Electrocardiogram
分类号:
R542.2+2
DOI:
10.3969/j.issn.1006-1959.2025.12.017
文献标志码:
A
摘要:
目的 观察替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死患者临床疗效及心电图变化的影响。方法 选取2022年4月-2024年3月宁都县人民医院收治的66例接受急诊PCI术后的急性ST段抬高型心肌梗死患者作为研究对象，按照随机数字表法将其分为对照组和研究组，每组33例。对照组使用氯吡格雷联合阿司匹林治疗，研究组使用替格瑞洛联合阿司匹林治疗。比较两组临床疗效、心功能[左室射血分数（LVEF）、左室收缩末直径（LVDS）、左室收缩末期容积（LVESV）、舒张末容积（LVEDV）、左室舒张末直径（LVDD）]、凝血功能[血浆D-二聚体（D-D）、凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（FIB）]、心电图变化（缺血总时间、T波倒置、24 h ST段下移）、不良反应（轻度出血、胃肠道不适、皮疹）发生率。结果 研究组治疗总有效率高于对照组（P＜0.05）；研究组LVEDV、LVDs、LVESV、LVDd均低于对照组，而LVEF均高于对照组（P＜0.05）；研究组PT、FIB、D-D均低于对照组，而TT均高于对照组（P＜0.05）；研究组缺血总时间、T波倒置、24 h ST段下移均低于对照组（P＜0.05）；研究组不良反应发生率低于对照组（P＜0.05）。结论 与氯吡格雷相比，替格瑞洛治疗急性ST段抬高型心肌梗死的效果更为确切，能够提高患者心功能以及凝血功能，改善患者心电图变化，且安全性较高，值得临床应用。
Abstract:
Objective To observe the effects of ticagrelor and clopidogrel on clinical efficacy and electrocardiogram changes in patients with acute ST-segment elevation myocardial infarction. Methods A total of 66 patients with acute ST-segment elevation myocardial infarction after emergency PCI admitted to Ningdu County People’s Hospital from April 2022 to March 2024 were selected as the research objects. According to the random number table method, they were divided into control group and study group, with 33 patients in each group. The control group was treated with clopidogrel combined with aspirin, and the study group was treated with ticagrelor combined with aspirin. The clinical efficacy, cardiac function [left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVDS), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic diameter (LVDD)], coagulation function [plasma D-dimer (D-D), prothrombin time (PT), thrombin time (TT), fibrinogen (FIB)], electrocardiogram changes (otal ischemia time, T wave inversion, 24 h ST segment depression) and incidence of adverse reactions (mild bleeding, gastrointestinal discomfort, rash) were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group (P<0.05). LVEDV, LVDs, LVESV and LVDd in the study group were lower than those in the control group, while LVEF was higher than that in the control group (P<0.05). PT, FIB and D-D in the study group were lower than those in the control group, while TT was higher than that in the control group (P<0.05). The total time of ischemia, T wave inversion and 24h ST segment depression in the study group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P<0.05). Conclusion Compared with clopidogrel, ticagrelor is more effective in the treatment of acute ST-segment elevation myocardial infarction, which can improve the cardiac function and coagulation function of patients, improve their electrocardiogram changes, and has high safety. It is worthy of clinical application.

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更新日期/Last Update: 1900-01-01