[1]赵东慧.阿替普酶静脉溶栓联合氯吡格雷对急性脑梗死患者脑血流动力学及CRP、Hcy、HDL-C水平的影响[J].医学信息,2022,35(20):74-76.[doi:10.3969/j.issn.1006-1959.2022.20.018]
 ZHAO Dong-hui.Effect of Alteplase Intravenous Thrombolysis Combined with Clopidogrel on Cerebral Hemodynamics and Levels of CRP, Hcy and HDL-C in Patients with Acute Cerebral Infarction[J].Journal of Medical Information,2022,35(20):74-76.[doi:10.3969/j.issn.1006-1959.2022.20.018]
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阿替普酶静脉溶栓联合氯吡格雷对急性脑梗死患者脑血流动力学及CRP、Hcy、HDL-C水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
74-76
栏目:
论著
出版日期:
2022-10-15

文章信息/Info

Title:
Effect of Alteplase Intravenous Thrombolysis Combined with Clopidogrel on Cerebral Hemodynamics and Levels of CRP, Hcy and HDL-C in Patients with Acute Cerebral Infarction
文章编号:
1006-1959(2022)20-0074-03
作者:
赵东慧
(佳木斯市中心医院神经内科,黑龙江 佳木斯 154003)
Author(s):
ZHAO Dong-hui
(Department of Neurology,Jiamusi Central Hospital,Jiamusi 154003,Heilongjiang,China)
关键词:
急性脑梗死阿替普酶静脉溶栓氯吡格雷脑血流动力学
Keywords:
Acute cerebral infarctionAlteplaseIntravenous thrombolysisClopidogrelCerebral hemodynamics
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.20.018
文献标志码:
A
摘要:
目的 探讨急性脑梗死患者联合应用阿替普酶静脉溶栓与氯吡格雷对患者脑血流动力学及C反应蛋白(CRP)、同型半胱氨酸(Hcy)、高密度脂蛋白(HDL-C)水平的影响。方法 选择2020年3月-2021年9月本院收治的40例急性脑梗死患者,随机分为观察组和对照组,各20例。对照组给予急性脑梗死对症治疗+氯吡格雷治疗,观察组在对照组基础上应用注射用阿替普酶治疗,比较两组临床疗效、用药及用药24 h后脑动脉血流峰值(Vp)、脉动指数(PI)、脑动脉平均流速(MFV)、脑灌注储备(CVR)、CRP、Hcy、HDL-C、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平。结果 用药24 h后,两组Vp、MFV、CVR、HDL-C、SOD、GSH-Px均较用药前上升,且观察组高于对照组,差异有统计学意义(P<0.05);两组PI、CRP、Hcy均较用药前下降,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率(95.00%)与对照组(70.00%)比较,差异无统计学意义(P>0.05)。结论 急性脑梗死患者联合应用阿替普酶静脉溶栓与氯吡格雷疗效确切,可改善患者脑血流动力学,降低CRP、Hcy水平,提升HDL-C水平,减轻脑氧化应激反应。
Abstract:
Objective To investigate the effects of alteplase intravenous thrombolysis combined with clopidogrel on cerebral hemodynamics and levels of C-reactive protein (CRP), homocysteine (Hcy) and high-density lipoprotein (HDL-C) in patients with acute cerebral infarction.Methods A total of 40 patients with acute cerebral infarction admitted to our hospital from March 2020 to September 2021 were randomly divided into observation group and control group, with 20 cases in each group. The control group was given symptomatic treatment of acute cerebral infarction + clopidogrel treatment, and the observation group was treated with Alteplase for injection on the basis of the control group. The clinical efficacy, medication and cerebral artery blood flow peak (Vp), pulse index (PI), cerebral artery mean flow velocity (MFV), cerebrovascular reserve (CVR), CRP, Hcy, HDL-C, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels were compared between the two groups.Results After 24 hours of treatment, Vp, MFV, CVR, HDL-C, SOD and GSH-Px in the two groups were higher than those before treatment, and those in the observation group were higher than the control group, the differences were statistically significant (P<0.05). The PI, CRP and Hcy of the two groups were lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant (P<0.05). There was no significant difference in the total effective rate between the observation group (95.00%) and the control group (70.00%) (P>0.05).Conclusion Alteplase intravenous thrombolysis combined with clopidogrel is effective in the treatment of patients with acute cerebral infarction, which can improve cerebral hemodynamics, reduce CRP and Hcy levels, increase HDL-C levels, and reduce cerebral oxidative stress.

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更新日期/Last Update: 1900-01-01