[1]赵东慧,王 楠,杨思远.阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及对脑血管储备功能的影响[J].医学信息,2023,36(13):151-154.[doi:10.3969/j.issn.1006-1959.2023.13.033]
　ZHAO Dong-hui,WANG Nan,YANG Si-yuan.Effect of Argatroban Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction and its Effect on Cerebrovascular Reserve Function[J].Journal of Medical Information,2023,36(13):151-154.[doi:10.3969/j.issn.1006-1959.2023.13.033]
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阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及对脑血管储备功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年13期
页码:
151-154
栏目:
论著
出版日期:
2023-07-01

文章信息/Info

Title:
Effect of Argatroban Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction and its Effect on Cerebrovascular Reserve Function
文章编号:
1006-1959（2023）13-0151-04
作者:
赵东慧; 王 楠; 杨思远
（佳木斯市中心医院神经内二科，黑龙江 佳木斯 154002）
Author(s):
ZHAO Dong-hui; WANG Nan; YANG Si-yuan
(The Second Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
阿加曲班; 阿替普酶; 静脉溶栓; 急性脑梗死; 脑血管储备功能
Keywords:
Argatroban; Alteplase; Intravenous thrombolysis; Acute cerebral infarction; Cerebrovascular reserve function
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2023.13.033
文献标志码:
A
摘要:
目的 分析急性脑梗死患者采用阿加曲班联合阿替普酶静脉溶栓治疗的临床疗效及对脑血管储备功能的影响。方法 选取2019年4月-2022年4月我院诊治的90例急性脑梗死患者为研究对象，采用随机数字表法分为对照组和观察组，各组45例。对照组采用阿替普酶静脉溶栓治疗，观察组在对照组基础上联合应用阿加曲班，比较两组临床治疗疗效、大脑动脉血流动力学指标[舒张末期流速（Vd）、收缩期峰值流速（Vp）、平均流速（Vm）]、神经功能缺损评分（NIHSS）、格拉斯哥昏迷（GCS）评分、日常生活能力（ADL）以及临床不良反应发生率。结果 观察组治疗总有效率为95.56%，高于对照组的80.00%（P＜0.05）；两组治疗后Vd、Vp、Vm均高于治疗前，且观察组高于对照组（P＜0.05）；两组治疗后NIHSS评分均低于治疗前，GCS、ADL评分均高于治疗前，且观察组NIHSS评分低于对照组，GCS、ADL评分高于对照组（P＜0.05）；观察组不良反应发生率为6.67%，与对照组的8.89%比较，差异无统计学意义（P＞0.05）。结论 阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效确切，可有效改善脑血管储备功能，促进神经功能恢复，提升患者日常生活能力，且联合治疗不增加不良反应发生几率，具有良好的应用有效性和安全性。
Abstract:
Objective To analyze the clinical efficacy of argatroban combined with alteplase intravenous thrombolysis in patients with acute cerebral infarction and its effect on cerebrovascular reserve function.Methods A total of 90 patients with acute cerebral infarction diagnosed and treated in our hospital from April 2019 to April 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 45 patients in each group. The control group was treated with alteplase intravenous thrombolysis, and the observation group was combined with argatroban on the basis of the control group. The clinical efficacy, cerebral artery hemodynamics indexes [end-diastolic velocity (Vd), peak systolic velocity (Vp), mean velocity (Vm)], neurological deficit score (NIHSS), Glasgow coma score (GCS), daily living ability (ADL) and incidence of clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.56%, which was higher than 80.00% in the control group (P<0.05). After treatment, Vd, Vp and Vm in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group (P<0.05). After treatment, the NIHSS scores of the two groups were lower than those before treatment, and the GCS and ADL scores were higher than those before treatment, while the NIHSS score of the observation group was lower than that of the control group, and the GCS and ADL scores were higher than those of the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.67%, which was compared with 8.89% in the control group, the difference was not statistically significant (P>0.05).Conclusion Argatroban combined with alteplase intravenous thrombolysis is effective in the treatment of acute cerebral infarction, which can effectively improve the cerebrovascular reserve function, promote the recovery of neurological function, and improve the daily living ability of patients. Meanwhile, the combined treatment does not increase the incidence of adverse reactions, and has good application effectiveness and safety.

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更新日期/Last Update: 1900-01-01