[1]吴浩瑜.院前急救中应用不同抗血小板药物组合对ST段抬高型急性心肌梗死患者近期心血管事件的影响[J].医学信息,2021,34(22):57-59.[doi:10.3969/j.issn.1006-1959.2021.22.016]
　WU Hao-yu.Effects of Different Antiplatelet Drug Combinations in Pre-hospital Emergency Treatment on Recent Cardiovascular Events in Patients with ST-segment Elevation Acute Myocardial Infarction[J].Medical Information,2021,34(22):57-59.[doi:10.3969/j.issn.1006-1959.2021.22.016]
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院前急救中应用不同抗血小板药物组合对ST段抬高型急性心肌梗死患者近期心血管事件的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年22期
页码:
57-59
栏目:
论著
出版日期:
2021-11-15

文章信息/Info

Title:
Effects of Different Antiplatelet Drug Combinations in Pre-hospital Emergency Treatment on Recent Cardiovascular Events in Patients with ST-segment Elevation Acute Myocardial Infarction
文章编号:
1006-1959（2021）22-0057-03
作者:
吴浩瑜
（天津市急救中心，天津 300171）
Author(s):
WU Hao-yu
(Tianjin Emergency Center,Tianjin 300171,China)
关键词:
院前急救; 抗血小板药物; 心血管事件; 替格瑞洛; 阿司匹林
Keywords:
Pre-hospital emergency; Antiplatelet drugs; Cardiovascular events; Tigrilo; Aspirin
分类号:
R542.22
DOI:
10.3969/j.issn.1006-1959.2021.22.016
文献标志码:
A
摘要:
目的 探究院前急救中应用不同抗血小板药物组合治疗对ST段抬高型急性心肌梗死患者近期心血管事件发生情况的影响。方法 回顾分析2019年9月-2020年9月天津市急救中心接诊的64例ST段抬高型急性心肌梗死患者，依据院前急救使用药物组合不同分为对照组（31例）和观察组（33例），两组均给予常规急救和阿司匹林治疗，对照组在上述基础上给予氯吡格雷治疗，观察组则给予替格瑞洛治疗；比较两组临床疗效、心功能指标、ST段回归基线时间、心血管事件发生率及不良反应发生情况。结果 观察组治疗总有效率高于对照组，差异有统计学意义（P＜0.05）；观察组LVEF、LVESD高于对照组，NT-pro BNP低于对照组，差异有统计学意义（P＜0.05）；观察组ST段回归基线时间短于对照组，差异有统计学意义（P＜0.05）；观察组心血管事件发生率为6.06%，低于对照组的22.58%，差异有统计学意义（P＜0.05）；观察组不良反应发生率低于对照组，差异有统计学意义（P＜0.05）。结论 院前急救中应用阿司匹林+替格瑞洛组合可提高ST段抬高型急性心肌梗死的治疗效果，缩短患者ST段恢复时间，改善其心功能，安全性良好。
Abstract:
Objective To explore the effect of different antiplatelet drug combinations in pre-hospital emergency treatment on recent cardiovascular events in patients with ST-segment elevation acute myocardial infarction.Methods Sixty-four patients with ST-segment elevation acute myocardial infarction admitted to Tianjin Emergency Center from September 2019 to September 2020 were retrospectively analyzed. According to the different drug combinations used in pre-hospital emergency treatment, they were divided into the control group (31 cases) and the observation group (33 cases). Both groups were given routine emergency treatment and aspirin treatment. The control group was given clopidogrel treatment on the basis of the above, and the observation group was given tegrelor treatment. The clinical efficacy, cardiac function indexes, ST segment regression baseline time, incidence of cardiovascular events and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05 ). LVEF and LVESD in the observation group were higher than those in the control group, NT-pro BNP was lower than that in the control group, and the difference was statistically significant (P<0.05). The baseline time of ST segment regression in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The incidence of cardiovascular events in the observation group was 6.06%, which was lower than 22.58% in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The combination of aspirin and ticagrelor in pre-hospital emergency treatment can improve the therapeutic effect of ST-segment elevation acute myocardial infarction, shorten the recovery time of ST segment, and improve the cardiac function, with good safety.

参考文献/References:

[1]范从华.院前抗凝治疗对ST段抬高心肌梗死患者预后影响分析[J].河北医学,2017,23(4):616-620.[2]周晓霞,田昕.血小板平均体积与老年人急性ST段抬高型心肌梗死近期主要心血管事件的相关性研究[J].中华老年医学杂志,2016(35):78.[3]林建华.早期应用抗血小板治疗老年ST 段抬高急性心肌梗死的有效性观察[J].北方药学,2015(3):90-91. [4]高晓飞.早期应用抗血小板治疗老年ST 段抬高急性心肌梗死的临床效果观察[J].中国实用医药,2016,11(24):152-153.[5]赵建军.不同剂量美托洛尔治疗老年ST 段抬高急性心肌梗死的疗效对比[J].吉林医学,2015(36):8057-8058.[6]Sahlén A,Varenhorst C,Lagerqvist B,et al.Outcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry[J].Eur Heart J,2016,37(44):3335-3342.[7]姚英文.冠心病心肌梗死患者院前急救中应用抗血小板影响心血管事件和心功能的临床研究[J].齐齐哈尔医学院学报,2018,39(14):47-49.[8]梁炯林,曾凡源,胡民坚,等.早期抗血小板干预对急性 ST段抬高心肌梗死患者的疗效分析[J].中国医学创新,2017,14(3):56-59.[9]Ibanez B,James S,Agewall S,et al.2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)[J].Eur Heart J,2018,39(2):119-177.[10]郭儒雅,武阳丰,赵威,等.急性ST段抬高型心肌梗死患者溶栓治疗时间对住院期间主要不良心脏事件发生率的影响[J].中华心血管病杂志,2016,44(2):128-132.[11]金彦彦,白融,叶明,等.不同抗血小板治疗策略对急性ST段抬高型心肌梗死患者冠状动脉血流及预后的影响[J].中国介入心脏病学杂志,2019,27(6):340-346.[12]Ye Y,Birnbaum GD,Perez-Polo JR,et al.Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction[J].Arterioscler Thromb Vasc Biol,2015,35(8):1805-1814.[13]李军锋.抗血小板治疗用于院前急救对ST段抬高性急性心肌梗死患者近期心血管事件的影响研究[J].云南医药,2021,42(1):25-26.[14]童随阳,蒋学俊,夏豪,等.替格瑞洛与氯吡格雷治疗急性ST段抬高型心肌梗死有效性和安全性的对比研究[J].实用心脑肺血管病杂志,2017,25(8):73-77

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更新日期/Last Update: 1900-01-01