[1]谢 甜,黄 伟.雾化吸入干扰素α2b注射液治疗对缩短病毒感染性肺炎患儿病程的影响及用药安全性对比研究[J].医学信息,2026,39(10):144-147.[doi:10.3969/j.issn.1006-1959.2026.10.026]
　XIE Tian,HUANG Wei.A Comparative Study on the Effect of Atomization Inhalation of Interferon α2b Injection onShortening the Course of Viral Pneumonia in Children and the Safety of Medication[J].Journal of Medical Information,2026,39(10):144-147.[doi:10.3969/j.issn.1006-1959.2026.10.026]
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雾化吸入干扰素α2b注射液治疗对缩短病毒感染性肺炎患儿病程的影响及用药安全性对比研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年10期
页码:
144-147
栏目:
临床证据信息
出版日期:
2026-05-15

文章信息/Info

Title:
A Comparative Study on the Effect of Atomization Inhalation of Interferon α2b Injection onShortening the Course of Viral Pneumonia in Children and the Safety of Medication
文章编号:
1006-1959（2026）10-0144-04
作者:
谢 甜1; 黄 伟2
1.宜春市袁州区妇幼保健院儿科，江西 宜春 336000；2.宜春市中医院儿科，江西 宜春 336000
Author(s):
XIE Tian1;  HUANG Wei2
1.Department of Pediatrics, Yuanzhou District Maternal and Child Health Hospital of Yichun City, Yichun 336000, Jiangxi, China;2. Department of Pediatrics, Yichun Hospital of Traditional Chinese Medicine, Yichun 336000, Jiangxi, China
关键词:
干扰素α2b注射液; 雾化治疗; 病毒性肺炎; 免疫功能; 炎性指标
Keywords:
Interferon α2b injection;  Atomization therapy;  Viral pneumonia;  Immune function;  Inflammatory indexes
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2026.10.026
文献标志码:
A
摘要:
目的 探究干扰素α2b注射液（IFN-α2b）雾化治疗对病毒感染性肺炎患儿的临床影响。方法 选取2022年1月-2024年12月宜春市袁州区妇幼保健院收治的60例病毒性肺炎患儿，行随机抽签法进行分组对照试验（常规组vs.干扰素组），各30例。常规组行常规治疗，观察组在其基础上应用IFN-α2b雾化治疗，比较两组疗效评价、症状消失时间（咳嗽、发热、肺部啰音）、肺部X线片阴影消失时间、炎性免疫指标[C反应蛋白（CRP）、淋巴细胞计数]、用药安全性。结果 干扰素组治疗有效率高于常规组，症状消失时间（咳嗽、发热、肺部啰音）、肺部X线片阴影消失时间短于常规组（P＜0.05）。两组治疗后CRP、淋巴细胞计数低于治疗前，且干扰素组CRP、淋巴细胞计数低于常规组（P＜0.05）。两组不良反应发生率对比，差异无统计学意义（P＞0.05）。结论 IFN-α2b雾化治疗可提升病毒性肺炎患儿的临床疗效，有助于缩短病程、缓解炎症，对患儿免疫功能具有积极改善作用，用药安全性佳。
Abstract:
Objective To investigate the clinical effects of interferon α2b injection (IFN-α2b) atomization therapy on children with viral pneumonia. Methods A total of 60 children with viral pneumonia admitted to Yuanzhou District Maternal and Child Health Hospital of Yichun City from January 2022 to December 2024 were randomly divided into two groups (conventional group vs. interferon group), 30 children in each group. The conventional group was treated with conventional treatment, while the observation group received IFN-α2b atomization therapy in addition to the conventional treatment. The two groups were compared in terms of treatment efficacy evaluation, symptom resolution time (cough, fever, pulmonary rales), resolution time of pulmonary X-ray opacities, inflammatory immune indicators [C-reactive protein (CRP), lymphocyte count], and medication safety. Results The effective rate of treatment in the interferon group was higher than that in the conventional group, and the disappearance time of symptoms (cough, fever, lung rales) and the disappearance time of lung X-ray shadow were shorter than those in the conventional group (P<0.05). After treatment, CRP and lymphocyte count in the two groups were lower than those before treatment, and CRP and lymphocyte count in the interferon group were lower than those in the conventional group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion IFN-α2 b atomization therapy can improve the clinical efficacy of children with viral pneumonia, help to shorten the course of disease, relieve inflammation, and actively improve the immune function of children with good drug safety.

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更新日期/Last Update: 1900-01-01