[1]舒 旭,蒋 婷,李姿萱.HMGB1与胃癌组织血管形成的关系及其临床意义[J].医学信息,2019,32(15):77-79.[doi:10.3969/j.issn.1006-1959.2019.15.024]
　SHU Xu,JIANG Ting,LI Zi-xuan.Relationship between HMGB1 and Angiogenesis in Gastric Carcinoma and its Clinical Significance[J].Journal of Medical Information,2019,32(15):77-79.[doi:10.3969/j.issn.1006-1959.2019.15.024]
点击复制

HMGB1与胃癌组织血管形成的关系及其临床意义()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年15期
页码:
77-79
栏目:
论著
出版日期:
2019-08-01

文章信息/Info

Title:
Relationship between HMGB1 and Angiogenesis in Gastric Carcinoma and its Clinical Significance
文章编号:
1006-1959（2019）15-0077-03
作者:
舒 旭1; 蒋 婷2; 李姿萱3
1.湖南医药学院医学院病理学与病理生理学教研室，湖南 怀化 418000； 2.湖南怀化市第一人民医院呼吸与危重症医学科，湖南 怀化 418000； 3.湖南医药学院护理学院，湖南 怀化 418000
Author(s):
SHU Xu1; JIANG Ting2; LI Zi-xuan3
1.Department of Pathology and Pathophysiology,School of Medicine,Hunan Medical College,Huaihua 418000,Hunan,China; 2.Department of Respiratory and Critical Care Medicine,the First People's Hospital of Huaihua, Huaihua 418000,Hunan,China; 3.College of Nurs
关键词:
胃癌; 血管生成; HMGB1; CD34
Keywords:
Key words：Gastric carcinoma; Angiogenesis; HMGB1; CD34
分类号:
R735.2
DOI:
10.3969/j.issn.1006-1959.2019.15.024
文献标志码:
A
摘要:
目的 确定高迁移率族蛋白B1与胃癌组织血管生成之间的联系，筛选胃癌诊断和治疗的靶点。方法 收集2008年6月~2016年6月怀化市第一人民医院病理科正常胃、胃癌旁、胃癌癌组织蜡块共105例，采用常规HE染色（苏木素-伊红）、免疫组织化学染色（链霉菌抗生物素蛋白-过氧化物酶连结法-SP法），检测正常胃组织、胃癌旁组织及胃癌组织中HMGB1的表达情况、检测人造血祖细胞抗原（CD34）的表达情况来反映正常胃组织、胃癌旁组织及胃癌组织中的微血管密度（MVD），统计学分析HMGB1的表达与胃癌组织MVD之间存在的相关性。结果 正常胃组织HMGB1的阳性表达率低，胃癌癌旁组织HMGB1的阳性表达率增高、胃癌组织中HMGB1的阳性表达率最高，在三种组织中HMGB1的表达存在差异（P＜0.05）；HMGB1的表达水平与MVD表现出正相关性（r=0.205，P＜0.05）。结论 HMGB1在胃组织、胃癌旁组织、胃癌组织中的表达呈阶梯型增高，胃癌组织中HMGB1的表达水平与组织MVD成正相关性。
Abstract:
Abstract：Objective To determine the relationship between high mobility group protein B1 and angiogenesis in gastric carcinoma, and to screen the target of diagnosis and treatment of gastric carcinoma. Methods A total of 105 cases of normal stomach, gastric carcinoma and gastric carcinoma tissue were collected from June 2008 to June 2016 in the Department of Pathology, First People's Hospital of Huaihua City, using conventional HE staining (hematoxylin-eosin) and immunohistochemical staining. Streptomyces avidin-peroxidase-linked-SP method, detecting the expression of HMGB1 in normal gastric tissue, para-cancerous tissues and gastric carcinoma tissues, and detecting the expression of human hematopoietic progenitor antigen (CD34) to reflect normal Microvessel density (MVD) in gastric tissue, paracancerous tissues and gastric carcinoma tissues, and statistical analysis of the correlation between HMGB1 expression and MVD in gastric carcinoma tissues.Results The positive expression rate of HMGB1 in normal gastric tissue was low, the positive expression rate of HMGB1 in gastric carcinoma tissues was increased, and the positive expression rate of HMGB1 was the highest in gastric carcinoma tissues. The expression of HMGB1 was different in three tissues (P<0.05). The expression level of HMGB1 was positively correlated with MVD (r=0.205,P<0.05).Conclusion The expression of HMGB1 in gastric tissue, paracancerous tissues and gastric carcinoma tissues is increased stepwise. The expression level of HMGB1 in gastric carcinoma tissues is positively correlated with tissue MVD.

参考文献/References:

[1]杨长群,刘婷婷,金志珊,等.TTTY10调控miR-490-3p通过HMGB1信号通路对宫颈癌细胞迁移和侵袭的影响[J].中国肿瘤生物治疗杂志,2018,25(6):562-567. [2]Zhang J,Zhu JS,Zhou Z,et al.Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo[J].Oncology Reports, 2012,27(5):1511-1519. [3]林国辉,王燕,杨家盛,等.老年肺癌患者组织HMGB1、MMP-9及VEGF-C的表达及临床意义[J].中国老年学杂志,2018,38(9):1511-1519. [4]李秋泽,杨成光.HMGB1及MMP-9在非小细胞肺癌及癌旁组织中的表达水平[J].贵州医科大学学报,2018,43(4):487-491. [5]赵东霞,卢安,王丽芳.食管癌组织HMGB1蛋白表达意义Meta分析[J].中华肿瘤防治杂志,2018,25(6):442-448. [6]龚龙,易春华,周明,等.HMGB1和HIF1a在乳头状甲状腺癌中的表达及意义[J].中国现代医学杂志,2019,29(4):28-32. [7]Tesarova P,Kalousova M,Zima T,et al.HMGB1,S100 proteins and other RAGE ligands in cancer-markers,mediators and putative therapeutic targets[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2016,160(1):1-10. [8]Cheng Y,Xiong J,Chen Q,et al.Hypoxia/reoxygenation-induced HMGB1 translocation and release promotes islet proinflammatory cytokine production and early islet graft failure through TLRs signaling[J].Biochim Biophys Acta Mol Basis Dis,2017,1863(2):354-364. [9]刘心怡,吴佳捷.高迁移率族蛋白B1基因沉默抑制子宫内膜癌侵袭与转移的机制[J].中南大学学报(医学版),2016,41(3):251-257. [10]梁曦,张成华,房明丽,等.乳腺癌肿瘤微环境中HMGB1蛋白及HMGB1/TLR4信号通路的水平[J].中国老年学杂志,2018,38(23):5798-5800. [11]Aguilar-Cazares D,Meneses-Flores M,Prado-Garcia H,et al.Relationship of Dendritic Cell Density,HMGB1 Expression,and Tumor-infiltrating Lymphocytes in Non-Small Cell Lung Carcinomas[J].Appl Immunohistochem Mol Morphol,2014,22(2):105-113. [12]Chen RC,Yi PP,Zhou RR,et al.The role of HMGB1-RAGE axis in migration and invasion of hepatocellular carcinoma cell lines[J].Molecular and Cellular Biochemistry,2014,390(1-2):271-280. [13]Gdynia G,Sauer SW,Kopitz J,et al.The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration[J].Nature Communications,2016(7):10764. [14]Tohme S,Yazdani HO,Liu Y,et al.Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction[J].Hepatology,2017,66(1):182-197. [15]Chen R,Zhu S,Fan XG,et al.HMGB1 Controls Liver Cancer Initiation through YAP-dependent Aerobic Glycolysis[J].Hepatology,2017,67(5):1823-1841.

相似文献/References:

[1]尹晓华,刘重元,黄 琳,等.胃癌中lncRNAs的研究进展[J].医学信息,2018,31(03):10.[doi:10.3969/j.issn.1006-1959.2018.03.004]
　YIN Xiao-hua,LIU Zhong-yuan,HUANG Lin,et al.Research Progress of lncRNAs in Gastric Cancer[J].Journal of Medical Information,2018,31(15):10.[doi:10.3969/j.issn.1006-1959.2018.03.004]
[2]芮昆昆,章 波,邰小华,等.基质金属蛋白酶2与蛋白磷酸酶2A的癌性抑制因子在胃癌中的研究进展[J].医学信息,2018,31(03):21.[doi:10.3969/j.issn.1006-1959.2018.03.007]
　RUI Kun-kun,ZHANG Bo,TAI Xiao-hua,et al.The Research Progress of Matrix Metalloproteinase 2 and Cancer Inhibitor of Protein Phosphatase 2A in Gastric Cancer[J].Journal of Medical Information,2018,31(15):21.[doi:10.3969/j.issn.1006-1959.2018.03.007]
[3]段 巍.1例晚期胃癌化疗并发嗜血细胞综合征患者的护理[J].医学信息,2018,31(10):181.[doi:10.3969/j.issn.1006-1959.2018.10.063]
　DUAN Wei.Nursing Care of a Case of Advanced Gastric Carcinoma with Hemophagocytic Syndrome after Chemotherapy[J].Journal of Medical Information,2018,31(15):181.[doi:10.3969/j.issn.1006-1959.2018.10.063]
[4]潘理会,李育庄,李春辉.胃癌与高凝血状态关系的研究现状[J].医学信息,2018,31(11):15.[doi:10.3969/j.issn.1006-1959.2018.11.005]
　PAN Li-hui,LI Yu-zhuang,LI Chun-hui.Research Status of the Relationship between Gastric Carcinoma and Hypercoagulable State[J].Journal of Medical Information,2018,31(15):15.[doi:10.3969/j.issn.1006-1959.2018.11.005]
[5]李虹霞,刘伏山.慢性萎缩性胃炎的中西医治疗[J].医学信息,2022,35(11):29.[doi:10.3969/j.issn.1006-1959.2022.11.009]
　LI Hong-Xia,LIU Fu-shan.Treatment of Chronic Atrophic Gastritis with Traditional Chinese and Western Medicine[J].Journal of Medical Information,2022,35(15):29.[doi:10.3969/j.issn.1006-1959.2022.11.009]
[6]梁延洋,程艳娜,华柏慧,等.胃癌合并2型糖尿病术后血糖改善的临床观察[J].医学信息,2018,31(17):187.[doi:10.3969/j.issn.1006-1959.2018.17.061]
　LIANG Yan-yang,CHENG Yan-na,HUA Bai-hui,et al.Clinical Observation of Postoperative Blood Glucose Improvement in Patients with Gastric Cancer Complicated with Type 2 Diabetes Mellitus[J].Journal of Medical Information,2018,31(15):187.[doi:10.3969/j.issn.1006-1959.2018.17.061]
[7]林跃韩,许庆文.腹腔镜uncut Roux-en-Y吻合与传统吻合方式的研究进展[J].医学信息,2018,31(22):31.[doi:10.3969/j.Ⅰssn.1006-1959.2018.22.010]
　LIN Yue-han,XU Qing-wen.Research Progress of Laparoscopic uncut Roux-en-Y Anastomosis and Traditional Anastomosis[J].Journal of Medical Information,2018,31(15):31.[doi:10.3969/j.Ⅰssn.1006-1959.2018.22.010]
[8]马玉涛,石文娜,李晓林,等.免疫荧光法检测FSHR与GnRHR在胃癌组织中的分布及其共定位研究[J].医学信息,2018,31(23):79.[doi:10.3969/j.issn.1006-1959.2018.23.022C]
　MA Yu-tao,SHI Wen-na,LI Xiao-lin,et al.Study on the Distribution and Co-localization of FSHR and GnRHR in Gastric Cancer Tissues by Immunofluorescence Assay[J].Journal of Medical Information,2018,31(15):79.[doi:10.3969/j.issn.1006-1959.2018.23.022C]
[9]赵 静.血浆纤维蛋白原和CA724水平在胃癌患者的变化及临床意义[J].医学信息,2018,31(24):82.[doi:10.3969/j.issn.1006-1959.2018.24.021]
　ZHAO Jing.Changes and Clinical Significance of Plasma Fibrinogen and CA724 Levels in Patients with Gastric Cancer[J].Journal of Medical Information,2018,31(15):82.[doi:10.3969/j.issn.1006-1959.2018.24.021]
[10]万 芳.以贫血为首发症状的消化道恶性肿瘤临床分析[J].医学信息,2018,31(24):175.[doi:10.3969/j.issn.1006-1959.2018.24.054]
　WAN Fang.Clinical Analysis of Digestive Tract Malignancies with Anemia as the First Symptom[J].Journal of Medical Information,2018,31(15):175.[doi:10.3969/j.issn.1006-1959.2018.24.054]

更新日期/Last Update: 2019-08-01