[1]王 然,佟成媛.糖尿病肾病患者尿微量白蛋白、免疫球蛋白G、转铁蛋白和视黄醇结合蛋白的检测及意义[J].医学信息,2019,(07):175-176.[doi:10.3969/j.issn.1006-1959.2019.07.056]
 WANG Ran,TONG Cheng-yuan.Detection and Significance of Urinary Microalbumin,Immunoglobulin G,Transferrin and Retinol Binding Protein in Patients with Diabetic Nephropathy[J].Medical Information,2019,(07):175-176.[doi:10.3969/j.issn.1006-1959.2019.07.056]
点击复制

糖尿病肾病患者尿微量白蛋白、免疫球蛋白G、转铁蛋白和视黄醇结合蛋白的检测及意义()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年07期
页码:
175-176
栏目:
诊疗技术
出版日期:
2019-04-01

文章信息/Info

Title:
Detection and Significance of Urinary Microalbumin,Immunoglobulin G,Transferrin and Retinol Binding Protein in Patients with Diabetic Nephropathy
文章编号:
1006-1959(2019)07-0175-02
作者:
王 然佟成媛
(佳木斯市中心医院检验科,黑龙江 佳木斯 154002)
Author(s):
WANG RanTONG Cheng-yuan
(Department of Clinical Laboratory,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
尿微量白蛋白免疫球蛋白G转铁蛋白视黄醇结合蛋白糖尿病肾病
Keywords:
Urinary microalbuminImmunoglobulin GTransferrinRetinol-binding proteinDiabetic nephropathy
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2019.07.056
文献标志码:
A
摘要:
目的 探究糖尿病肾病患者尿微量白蛋白、免疫球蛋白G、转铁蛋白和视黄醇结合蛋白的检测及意义。方法 选取2017年11月~2018年11月我院接收的310例糖尿病肾病患者设为糖尿病肾病组,另选240例健康体检者设为健康体检组,分别进行尿微量白蛋白、免疫球蛋白G、转铁蛋白和视黄醇结合蛋白的检测,比较两组以上指标检测结果。结果 糖尿病肾病组经过检测后尿微量白蛋白(90.18±20.06) mg·L-1、免疫球蛋白G(9.15±2.89) mg·L-1、转铁蛋白(6.11±1.58) mg·L-1和视黄醇结合蛋白(3.21±1.69) mg·L-1均高于健康体检组的尿微量白蛋白(9.11±2.15) mg·L-1、免疫球蛋白G(2.46±0.12) mg·L-1、转铁蛋白(0.49±0.22) mg·L-1、和视黄醇结合蛋白(0.63±0.12) mg·L-1,差异有统计学意义(P<0.05);糖尿病肾病组尿微量白蛋白、免疫球蛋白G、转铁蛋白、视黄醇结合蛋白阳性率均高于健康体检组,差异有统计学意义(P<0.05)。结论 尿微量白蛋白、免疫球蛋白G、转铁蛋白和视黄醇结合蛋白的联合检测拥有着极高的诊断质量,将其用于临床的辅助诊断之中,有利于帮助检测人员获取患者更多疾病诊断的早期依据,对于患者疾病治疗效果的提升也有着积极的推动作用。
Abstract:
Objective To explore the detection and significance of urinary microalbumin, immunoglobulin G, transferrin and retinol binding protein in patients with diabetic nephropathy. Methods From November 2017 to November 2018, 310 patients with diabetic nephropathy received by our hospital were enrolled in the diabetic nephropathy group, and 240 healthy subjects were selected as the physical examination group. The urine microalbumin and immunoglobulin G were separately administered. The detection of transferrin and retinol binding protein was compared between the two groups. Results In the diabetic nephropathy group, urine microalbumin (90.18±20.06) mg·L-1, immunoglobulin G (9.15±2.89) mg·L-1, transferrin (6.11±1.58) mg·L-1 were detected and retinol binding protein (3.21±1.69) mg·L-1 were higher than the urine microalbumin (9.11±2.15) mg·L-1 and immunoglobulin G (2.46±0.12) mg·L-1 in the healthy examination group, transferrin (0.49±0.22) mg·L-1, and retinol-binding protein (0.63±0.12) mg·L-1, the difference was statistically significant (P<0.05).The micro-urine,the positive rates of albumin, immunoglobulin G, transferrin and retinol binding protein of diabetic nephropathy group were higher than those in healthy subjects (P<0.05). Conclusion The combined detection of urinary microalbumin, immunoglobulin G, transferrin and retinol binding protein has a very high diagnostic quality, which can be used in clinical auxiliary diagnosis, which helps the tester to obtain patients more.The early basis of multi-disease diagnosis has a positive effect on the improvement of patients' disease treatment.

参考文献/References:


[1]张岱,叶山东,陈超.尿系列蛋白检测在2型糖尿病肾脏疾病诊断中的意义[J].安徽医学,2017,38(3):339-342.
[2]齐莹莹.尿六联蛋白检测在糖尿病早期肾损伤诊断中的意义[J].医学理论与实践,2018,5(2):261-263.
[3]陈耀锋,管慧,詹前柱.糖尿病肾病患者尿液微量白蛋白和视黄醇结合蛋白检测的意义[J].包头医学院学报,2016,32(11):84-85.
[4]贾冬霞,彭君臣,刘思泰,等.老年2型糖尿病患者尿液中mAlb、IgG、RBP、β2-MG水平及其意义分析[J].医学理论与实践,2017,30(17):2604-2605.
[5]宁冬梅,丁涛.血清胱抑素C、视黄醇结合蛋白以及尿微量白蛋白联合检测在糖尿病肾病临床诊断中的意义[J].中国实验诊断学,2016,20(12):2055-2057.
[6]吴家斌,洪富源,杨国凯,等.血清CysC、RBP和尿TRF、mAlb检测在糖尿病肾病早期诊断中的意义[J].广西医科大学学报,2017,34(8):1153-1156.
[7]谭昆,李全双,吴燕,等.2型糖尿病患者检测尿视黄醇结合蛋白和尿微量白蛋白/尿肌酐比值的临床意义[J].中国校医,2016,30(4):303-304.
[8]王晓燕.血清胱抑素C、β2-微球蛋白、视黄醇结合蛋白、尿微量白蛋白及N-乙酰-β-D-氨基葡萄糖苷酶在诊断糖尿病早期肾损伤中的临床意义[J].新乡医学院学报,2017,34(2):143-146.

相似文献/References:

[1]贺 伟,高 峰.24 h尿微量白蛋白、血清胱抑素C水平与血清肌酐、尿素水平在2型糖尿病肾病早期诊断的意义[J].医学信息,2018,(11):151.[doi:10.3969/j.issn.1006-1959.2018.11.049]
 HE Wei,GAO Feng.The Significance of 24 h Urinary Microalbumin,Serum Cystatin C and Serum Creatinine and Urea Levels in the Early Diagnosis of Type 2 Diabetic Nephropathy[J].Medical Information,2018,(07):151.[doi:10.3969/j.issn.1006-1959.2018.11.049]
[2]周 琛.尿微量白蛋白和尿糖检测对糖尿病早期肾损伤的 临床意义分析[J].医学信息,2018,(16):159.[doi:10.3969/j.issn.1006-1959.2018.16.051]
 ZHOU Chen.Clinical Significance of Urinary Microalbumin and Urine Glucose in Early Renal Injury in Diabetes Mellitus[J].Medical Information,2018,(07):159.[doi:10.3969/j.issn.1006-1959.2018.16.051]

更新日期/Last Update: 2019-04-01