[1]寇 天,郝振伟,陈 曦.尿微量白蛋白/肌酐比值、血清肌酐和血清胱抑素C对老年高血压患者早期肾损害的诊断价值研究[J].医学信息,2023,36(02):103-106.[doi:10.3969/j.issn.1006-1959.2023.02.020]
　KOU Tian,HAO Zhen-wei,CHEN Xi.The Diagnostic Value of Urinary Albumin/Creatinine Ratio, Serum Creatinine and Serum Cystatin C in Early Renal Damage in Elderly Patients with Hypertension[J].Journal of Medical Information,2023,36(02):103-106.[doi:10.3969/j.issn.1006-1959.2023.02.020]
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尿微量白蛋白/肌酐比值、血清肌酐和血清胱抑素C对老年高血压患者早期肾损害的诊断价值研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年02期
页码:
103-106
栏目:
论著
出版日期:
2023-01-15

文章信息/Info

Title:
The Diagnostic Value of Urinary Albumin/Creatinine Ratio, Serum Creatinine and Serum Cystatin C in Early Renal Damage in Elderly Patients with Hypertension
文章编号:
1006-1959（2023）02-0103-04
作者:
寇 天; 郝振伟; 陈 曦
（佳木斯市中医医院检验科1，神经内科2，黑龙江 佳木斯 154002）
Author(s):
KOU Tian; HAO Zhen-wei; CHEN Xi
(Department of Laboratory1,Department of Neurology2,Jiamusi Traditional Chinese Medicine Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
尿微量白蛋白; 血清肌酐; 血清胱抑素C; 老年高血压; 肾损害
Keywords:
Microalbuminuria; Serum creatinine; Serum cystatin C; Senile hypertension; Renal damage
分类号:
R544.1
DOI:
10.3969/j.issn.1006-1959.2023.02.020
文献标志码:
A
摘要:
目的 研究尿微量白蛋白/肌酐比值（mAlb/Cr，UACR）、血清肌酐（SCr）和血清胱抑素C（CysC）对老年高血压患者早期肾损害的诊断价值。方法 选取2021年1月-2022年1月在我院诊治的94例老年高血压患者设为观察组，并选取同期90例非高血压患者作为对照组。依据肾小球滤过率（GFR）将两组分别分为早期肾损伤、肾功能正常两个亚组，比较各组UACR、SCr、CysC水平以及UACR、SCr、CysC单独检测与UACR联合CysC诊断老年高血压患者早期肾损害的价值。结果 观察组UACR、CysC均高于对照组（P＜0.05）；观察组SCr与对照组比较，差异无统计学意义（P＞0.05）；高血压3级患者UACR、CysC均高于高血压1级患者、高血压2级患者以及对照组，且高血压2级患者高于高血压1级患者及对照组，高血压1级患者高于对照组（P＜0.05）；高血压3级患者SCr高于对照组、高血压1级患者、高血压2级患者，但对照组、高血压1级患者、高血压2级患者比较，差异无统计学意义（P＞0.05）；观察组肾功能损伤患者UACR、SCr、CysC均高于对照组肾功能损伤患者，观察组肾功能正常患者UACR、SCr、CysC均高于对照组肾功能正常患者，且观察组肾功能损伤患者UACR、SCr、CysC均高于对照组肾功能正常患者（P＜0.05）；UACR联合CysC诊断高血压患者早期肾损害灵敏度高于CysC、UACR、SCr，且CysC高于UACR和SCr，UACR高于SCr（P＜0.05），但各指标特异度比较，差异无统计学意义（P＞0.05）。结论 老年高血压患者UACR、CysC水平均显著升高，但SCr仅在高血压晚期阶段才会表现出显著升高，且UACR、CysC水平随血压级别升高呈不断上升趋势。同时UACR、CysC、SCr均可一定程度反映老年高血压患者早期肾功能损害，但相比较UACR联合CysC可提高老年高血压患者早期肾损害诊断效能。
Abstract:
Objective To study the diagnostic value of urinary microalbumin/creatinine ratio (mAlb/Cr, UACR), serum creatinine (SCr) and serum cystatin C (CysC) for early renal damage in elderly patients with hypertension.Methods A total of 94 elderly patients with hypertension diagnosed and treated in our hospital from January 2021 to January 2022 were selected as the observation group, and 90 non-hypertensive patients in the same period were selected as the control group. According to glomerular filtration rate (GFR), the two groups were divided into two subgroups of early renal injury and normal renal function. The levels of UACR, SCr and CysC in each group were compared, and the value of UACR, SCr and CysC alone and UACR+CysC in the diagnosis of early renal injury in elderly hypertensive patients was compared.Results UACR and CysC in the observation group were higher than those in the control group (P<0.05). UACR and CysC in patients with grade 3 hypertension were higher than those in patients with grade 1 hypertension, patients with grade 2 hypertension and control group, and patients with grade 2 hypertension were higher than those in patients with grade 1 hypertension and control group, and patients with grade 1 hypertension were higher than those in control group (P<0.05). The SCr of patients with grade 3 hypertension was higher than that of the control group, patients with grade 1 hypertension and patients with grade 2 hypertension, but there was no significant difference among the control group, patients with grade 1 hypertension and patients with grade 2 hypertension (P>0.05). UACR, SCr and CysC in patients with renal function injury in the observation group were higher than those in the control group, while UACR, SCr and CysC in patients with normal renal function in the observation group were higher than those in the control group, and UACR, SCr and CysC in patients with renal function injury in the observation group were higher than those in the control group (P<0.05). The sensitivity of UACR+CysC combined diagnosis of early renal damage in hypertensive patients was higher than that of CysC, UACR and SCr, and CysC was higher than UACR and SCr, UACR was higher than SCr (P<0.05), but there was no significant difference in the specificity of each index (P>0.05).Conclusion The levels of UACR and CysC in elderly patients with hypertension are significantly increased, but SCr is only significantly increased in the late stage of hypertension, and the levels of UACR and CysC are increasing with the increase of blood pressure level. At the same time, UACR, CysC and SCr can reflect the early renal damage in elderly patients with hypertension to a certain extent, but compared with UACR+CysC combined can improve the diagnostic efficiency of early renal damage in elderly patients with hypertension.

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更新日期/Last Update: 1900-01-01