[1]鲍江波.雷公藤多苷和泼尼松片联合治疗特发性膜性肾病的有效性分析[J].医学信息,2020,33(14):157-158.[doi:10.3969/j.issn.1006-1959.2020.14.050]
　BAO Jiang-bo.Analysis of the Efficacy of Tripterygium Glycosides and Prednisone Tablets in the Treatment of Idiopathic Membranous Nephropathy[J].Medical Information,2020,33(14):157-158.[doi:10.3969/j.issn.1006-1959.2020.14.050]
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雷公藤多苷和泼尼松片联合治疗特发性膜性肾病的有效性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年14期
页码:
157-158
栏目:
药物与临床
出版日期:
2020-07-15

文章信息/Info

Title:
Analysis of the Efficacy of Tripterygium Glycosides and Prednisone Tablets in the Treatment of Idiopathic Membranous Nephropathy
文章编号:
1006-1959（2020）14-0157-02
作者:
鲍江波
（佳木斯市中心医院肾内科，黑龙江 佳木斯 154002）
Author(s):
BAO Jiang-bo
(Department of Nephrology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
雷公藤多苷; 小剂量激素; 特发性膜性肾病
Keywords:
Tripterygium glycosides; Low-dose hormone; Idiopathic membranous nephropathy
分类号:
R692
DOI:
10.3969/j.issn.1006-1959.2020.14.050
文献标志码:
A
摘要:
目的 研究雷公藤多苷和小剂量激素联合治疗特发性膜性肾病的有效性及可行性。方法 选取2018年10月~2019年10月在我院治疗的108例特发性膜性肾病患者为研究对象，采用随机数字表法分为对照组和观察组，各54例。对照组采用雷公藤多苷治疗，观察组在对照组基础上应用小剂量激素治疗，比较两组临床治疗总有效率、治疗前后24h尿蛋白、血清白蛋白、血尿素氮、胆固醇水平以及临床不良反应发生情况。结果 观察组临床治疗总有效率为92.59%，高于对照组的81.48%，差异有统计学意义（P＜0.05）；治疗后两组24h尿蛋白、血尿素氮、胆固醇水平均低于治疗前，血清白蛋白水平均高于治疗前，且观察组优于对照组，差异有统计学意义（P＜0.05）；观察组临床不良反应发生率低于对照组，差异有统计学意义（P＜0.05）。结论 雷公藤多苷和小剂量激素联合治疗特发性膜性肾病疗效确切，有助于改善肾功能指标及血脂水平，且临床不良反应少，应用安全可行。
Abstract:
Objective To study the efficacy and feasibility of combining tripterygium glycosides and low-dose hormone in the treatment of idiopathic membranous nephropathy.Methods A total of 108 patients with idiopathic membranous nephropathy treated in our hospital from October 2018 to October 2019 were selected as the research object. They were divided into a control group and an observation group with a random number table method, 54 cases each. The control group was treated with tripterygium glycosides, and the observation group was treated with low-dose hormone therapy on the basis of the control group. The total clinical efficacy of the two groups was compared, and the 24h urine protein, serum albumin, blood urea nitrogen, cholesterol level and clinical dysfunction before and after treatment the reaction happened.Results The total effective rate of clinical treatment in the observation group was 92.59%, which was higher than 81.48% in the control group,the difference was statistically significant (P＜0.05).After treatment, the 24h urine protein, blood urea nitrogen, and cholesterol levels were lower than before treatment, and the serum albumin level was higher than before treatment, and the observation group was better than the control group, the difference was statistically significant (P＜0.05); observation the incidence of clinical adverse reactions in the group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion The combination of tripterygium glycosides and low-dose hormone in the treatment of idiopathic membranous nephropathy has definite curative effect, which can help to improve the renal function indexes and blood lipid levels.

参考文献/References:

[1]李琳琳.激素联合不同免疫抑制剂治疗特发性膜性肾病的临床比较[J].中国医药指南,2016,14(16):180-181.[2]张连云,王树龙,朱铁锤.黄葵胶囊联合他克莫司和泼尼松治疗特发性膜性肾病的疗效观察[J].现代药物与临床,2017,32(6):1061-1064.[3]常雄.他克莫司或来氟米特联合泼尼松治疗特发性膜性肾病的疗效及安全性对比[J].药物评价研究,2016,39(5):825-827.[4]王庆芳.小剂量他克莫司联合雷公藤多苷多靶点治疗特发性膜性肾病的临床疗效[J].中国医药指南,2017,15(17):14-15.[5]彭健韫,兰乐健,张小如.小剂量他克莫司联合雷公藤多苷治疗特发性膜性肾病的临床研究[J].中国临床药理学杂志,2015, 31(11):905-908.

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更新日期/Last Update: 1900-01-01