[1]谢祥红.AngⅡ、ET-1对高血压患者病情发生发展的影响[J].医学信息,2020,33(16):75-77.[doi:10.3969/j.issn.1006-1959.2020.16.023]
　XIE Xiang-hong.Effects of AngⅡ and ET-1 on the Occurrence and Development of Hypertension Patients[J].Medical Information,2020,33(16):75-77.[doi:10.3969/j.issn.1006-1959.2020.16.023]
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AngⅡ、ET-1对高血压患者病情发生发展的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年16期
页码:
75-77
栏目:
论著
出版日期:
2020-08-15

文章信息/Info

Title:
Effects of AngⅡ and ET-1 on the Occurrence and Development of Hypertension Patients
文章编号:
1006-1959（2020）16-0075-03
作者:
谢祥红
（武警四川省总队医院检验科，四川 乐山 614000）
Author(s):
XIE Xiang-hong
(Department of Laboratory Medicine,Sichuan Provincial Corps Hospital of Armed Police,Leshan 614000,Sichuan,China)
关键词:
原发性高血压; 血管紧张素Ⅱ; 内皮素-1
Keywords:
Essential hypertension; Angiotensin Ⅱ; Endothelin-1
分类号:
R544.1
DOI:
10.3969/j.issn.1006-1959.2020.16.023
文献标志码:
B
摘要:
目的 探讨原发性高血压（EH）患者血浆血管紧张素Ⅱ（AngⅡ）、内皮素-1（ET-1）的变化及其意义。方法 选取2017年1月~2018年8月我院首诊的EH患者140例设为EH组，另选取同期我院健康体检的志愿者70例设为对照组，比较两组血浆中AngⅡ、ET-1水平、24h平均收缩压（24h SBP）、24h平均舒张压（24h DBP）、24h收缩压变异系数（24h SCV）、24h舒张压（24h DCV）、不同高血压分级的EH患者血浆AngⅡ、ET-1水平，并分析AngⅡ、ET-1水平与血压及血压变异性指标的相关性。结果 EH组血浆AngⅡ、ET-1水平高于对照组[（60.74±19.51）ng/L vs（20.40±8.51）ng/L]、[（3.36±0.95）ng/ml vs（1.26±0.24）ng/ml]，差异有统计学意义（P＜0.05）；EH组24h SBP、24h DBP、24h SCV、24h DCV高于对照组，差异有统计学意义（P＜0.05）；3级、2级的EH患者血浆AngⅡ、ET-1水平高于1级，3级的EH患者血浆AngⅡ、ET-1水平高于2级，差异有统计学意义（P＜0.05）；EH患者血浆AngⅡ、ET-1水平与24h SBP、24h DBP、24h SCV、24h DCV均呈正相关关系（P<0.05）。结论 EH患者血浆AngⅡ、ET-1水平较健康人群增高，且与患者血压水平及血压变异性增大有关。
Abstract:
Objective To explore the changes and significance of plasma angiotensin II (Ang II) and endothelin-1 (ET-1) in patients with essential hypertension (EH).Methods A total of 140 patients with EH who were first diagnosed in our hospital from January 2017 to August 2018 were selected as the EH group, and 70 volunteers who received physical examination in our hospital during the same period were selected as the control group.The plasma levels of AngⅡ, ET-1, 24h average systolic blood pressure (24h SBP), 24h average diastolic blood pressure (24h DBP), 24h systolic blood pressure variation coefficient (24h SCV), 24h diastolic blood pressure (24h DCV), different heights were compared between the two groups The plasma levels of AngⅡ and ET-1 in EH patients with blood pressure classification, and the correlation between AngⅡ and ET-1 levels and blood pressure and blood pressure variability indexes were analyzed.Results The plasma levels of AngⅡ and ET-1 in the EH group were higher than those in the control group [(60.74±19.51)ng/L vs (20.40±8.51)ng/L], [(3.36±0.95)ng/ml vs(1.26±0.24)ng/ml], the difference was statistically significant (P<0.05); 24h SBP, 24h DBP, 24h SCV, and 24h DCV in the EH group were higher than those of the control group,the difference was statistically significant (P<0.05); Grade 3 and 2 EH The plasma AngⅡ and ET-1 levels of patients were higher than grade 1, and the plasma AngⅡ and ET-1 levels of patients with grade 3 EH were higher than grade 2,the difference was statistically significant (P＜0.05);Plasma AngⅡ and ET-1 levels in EH patients were positively correlated with 24h SBP, 24h DBP, 24h SCV, and 24h DCV (P<0.05).Conclusion The levels of plasma AngⅡ and ET-1 in EH patients were higher than those in healthy people, and they were related to the increase of blood pressure level and blood pressure variability.

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更新日期/Last Update: 1900-01-01